WERAM Information

Tag Content
WERAM ID WERAM-Mum-0100
Ensembl Protein ID ENSMUSP00000031680.3
Uniprot Accession Q8VEK6; ING3_MOUSE; Q99JS6; Q9ERB2
Genbank Protein ID NP_001297990.1; NP_076115.3
Protein Name Inhibitor of growth protein 3
Genbank Nucleotide ID NM_001311061.1; NM_023626.4
Gene Name ING3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000029670.12 ENSMUST00000031680.9 ENSMUSP00000031680.3
ENSMUSG00000029670.12 ENSMUST00000115389.7 ENSMUSP00000111047.1
Details
Type Family Domain Substrates AA References (PMIDs)
Me_Reader PHD PHD-type H3K4me2/3 K 24463511
Status Reviewed
Classification
Type Family E-value Score Start End
Me_Reader PHD 7.20e-12 46.8 364 410
Organism Mus musculus
NCBI Taxa ID 10090
Functional Description
(View)		 Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome (By similarity).
Domain Profile
  Me_Reader PHD
               PHD.txt   2 tiClvCgkddegekemvqCde..Cd.dwfHlkCvklplsslpegkswyCpsCk 51 
                            +C+ C+++++ge  mv Cd+  C+ +wfH+ Cv+l+  ++p+g +w+Cp+C+
  ENSMUSP00000031680.3 364 RYCI-CNQVSYGE--MVGCDNqdCPiEWFHYGCVGLT--EAPKG-KWFCPQCT 410
                           69*9.*******6..**********************..*****.*******8 PP
Protein Sequence
(Fasta)		MLYLEDYLEM IEQLPMDLRD RFTEMREMDL QVQNAMDQLE QRVSEFFMNA KKNKPEWREE 60
QMASIKKDYY KALEDADEKV QLANQIYDLV DRHLRKLDQE LAKFKMELEA DNAGITEILE 120
RRSLELDAPS QPVNNHHAHS HTPVEKRKYN PTSHHAAADH IPEKKFKSEA LLSTLTSDAS 180
KENTLGCRNN NSTASCNNAY NVNSSQPLAS YNIGSLSSGA GAGAITMAAA QAVQATAQMK 240
EGRRTSSLKA SYEAFKNNDF QLGKEFSIPR ETAGYSSSSA LMTTLTQNAS SSATDSRSGR 300
KSKNNTKSSS QQSSSSSSSS SSSSLSLCSS SSTVVQEVSQ QATVVPESDS NSQVDWTYDP 360
NEPRYCICNQ VSYGEMVGCD NQDCPIEWFH YGCVGLTEAP KGKWFCPQCT AAMKRRGSRH 420
K 421
Nucleotide Sequence
(Fasta)		GAGGCAAGCG CCGTCAGGCG CCAAAGTGGA GCCTTTTTTT TTTTCCTTTG CTTTTTTTTT 60
TTTTTTTTTC CTTTGCCGGA GTCGAGCGGG TGCTGCTAGC GGAGGCGCCA TATTGGAAGG 120
GACAAAACTC CGGCGACAGC GAGTGACACA AATAAACCCC TGGACCCGTT CGTCCCCGCA 180
ACAGTCAGGG CCGCGATGTT GTACCTAGAG GACTATTTGG AAATGATTGA GCAGCTTCCG 240
ATGGACCTAC GGGACCGCTT CACGGAGATG CGCGAGATGG ATCTGCAGGT GCAGAATGCA 300
ATGGATCAAC TAGAACAAAG AGTCAGTGAG TTCTTTATGA ATGCAAAGAA GAATAAACCC 360
GAGTGGCGAG AAGAACAGAT GGCATCCATC AAAAAAGACT ACTATAAAGC TTTGGAAGAT 420
GCAGATGAGA AAGTACAGTT GGCAAACCAG ATTTATGATT TGGTAGATCG CCACTTGAGA 480
AAGCTGGATC AGGAACTGGC CAAGTTTAAA ATGGAGCTGG AAGCCGATAA TGCTGGAATT 540
ACAGAAATAC TAGAGAGGCG ATCTTTGGAA TTAGATGCTC CTTCGCAGCC AGTGAACAAT 600
CACCACGCTC ATTCACATAC TCCCGTGGAA AAAAGGAAAT ATAATCCAAC TTCTCACCAT 660
GCAGCAGCAG ACCATATCCC TGAGAAGAAA TTCAAATCTG AAGCGCTGCT GTCCACCCTT 720
ACATCTGACG CTTCCAAGGA GAACACGCTG GGTTGTCGGA ACAATAATTC CACAGCTTCC 780
TGCAACAATG CTTACAATGT GAACTCGTCC CAGCCCCTGG CCTCCTATAA CATTGGTTCA 840
TTATCTTCAG GGGCTGGCGC AGGGGCCATC ACCATGGCGG CAGCACAGGC CGTGCAAGCG 900
ACAGCACAGA TGAAAGAAGG GCGAAGAACA TCGAGTTTAA AAGCCAGTTA CGAAGCATTT 960
AAGAACAATG ACTTCCAGCT GGGAAAAGAA TTTTCCATAC CCAGAGAAAC AGCTGGCTAC 1020
TCCTCCTCAT CGGCACTCAT GACAACCTTA ACCCAGAATG CCAGTTCCTC CGCCACGGAC 1080
TCGCGGAGTG GCAGGAAGAG CAAAAACAAC ACCAAGTCTT CAAGCCAGCA GTCGTCGTCC 1140
TCCTCCTCCT CGTCGTCCTC TTCCTCCTTA TCTCTGTGTT CATCGTCTTC AACTGTAGTA 1200
CAAGAAGTTT CCCAGCAAGC AACTGTAGTG CCCGAATCTG ACTCCAACAG TCAAGTCGAT 1260
TGGACTTACG ACCCAAATGA ACCTCGGTAT TGCATCTGTA ATCAGGTATC CTATGGAGAG 1320
ATGGTGGGAT GTGATAACCA AGATTGTCCA ATAGAGTGGT TCCACTATGG GTGTGTTGGC 1380
TTGACCGAAG CGCCGAAGGG GAAGTGGTTC TGTCCGCAGT GCACCGCTGC CATGAAGAGA 1440
AGAGGCAGTC GGCACAAATA GAGAGGGACT CTATTGTCAC TGCAGGAAGG AGGAACTCCA 1500
GCTCGCCATT TTATACAGGA CGCTAGGAGG AAAGACACGA GGACGAAGAA GCAGCTCATC 1560
TCCAGGCCAC CACTTAGAGG ATTACAGAGA CAATCCTATA AGATCTTGAA CTTGAATTTT 1620
ATGAGTTGTA TTTTAATAAT GTAAGTAAAT TATTTATGCA CTCCTGGTGT GCTATGAATA 1680
TTATTCCAGT TAGCCTTGGA TTATTTCTGT GGCCAACATA TGCAGACATT TGTACTCCAA 1740
CCATTTTCTC AAAGTAATGG GCATTCTATA ATTTAAACTT CAAAGAATTC CAACGATGAA 1800
GATTTTAAGA AAGTATTTTA TATTCAACAG GTATATTCAG CTGCATGTAC TGTACTCCAG 1860
AGCTGTTATG TTACACTGTA TATAAATGGT TGCAAAAAAC AAAAACAAAA AACAAAATAC 1920
AAACAAAAAA AGTCAGTCCT TCTAAAAAGG ATTTAAGATA ATGGTTTTTA AGATGCCTTT 1980
ATAATAAGCT TTGTTTCTTT GTGAAACTCA TTCAGCAGGC TGAAGGAATT GGTTTATGTG 2040
GTAAAGTGGG CTGGTGTCCT CTAGAGTACC TGGGTACATA AACAGAAACT CCTGTAGGTA 2100
AAACCTGATC CGTGCCATTA GTCTCTATGT TTCTGCATCC AGATAGAGTG CAGCTCACGC 2160
TCAAGGGGGT GGGGGCGGGG GCTCCGGGGG AAAGGGCGTT AAAGTGATAC ATTTTTATAC 2220
CAAATGTGTT TATTTTTTTG TGCGAGTAAT CCTTAAATTG GAATTGTATT AGGTGTTAAA 2280
ATAAAGTTTT TTAAAAAATA ACTTGTATTT ATACTTTACA CACTTAATTA TGAAAATTTC 2340
TTAATTGCAA TTTATTCCTA ATTTTCATAA TCCAAAAAAG ATTAGAGGTT AGCATGCAGA 2400
ATGCTATGTA ATCTATGATT TCTATAATGA TGGCTGGAAA TTGTGTTATG AGGATAAGGA 2460
AAGAACATTT TAAATGTAAA TTTGAAGTGT CAAATGTATT TTTCTAGAAT ATTTCTCTGG 2520
CTTTGCTTTG AATCTAAGGG ATATAAAAAG AACCTAATTA CAGTAGATAC AATGAAAATA 2580
ATGGCTATAG ATGTTTGGAC TGGAAGCAGT GTGGCCAATA TGACTTAAAG AGACCTTAAA 2640
ATATAATTTT GTTTTTAATT CTCTGACATC GTGATGTGGC AGTTAATTAA CTCTTAAATC 2700
ACTCTGGGCT TTGTGAAACC AAAATAATGC AGGTTGTGGG ATGTCTTCAA AACACTCCTA 2760
AGGACTTGTT CTATAGGTGC TATTTAGGTG ATGGACTTTA CATAGTGGAG ACTTCACTTA 2820
ATAGATGTTC AGTAGATGGG TAGAAAAATT GATGAAACTT CAAAGATCAG ACTTCCTCTA 2880
CATTGAAATA TATGAAATCC ACATATGCTT TAATGAAGCC CACTTCTGAA TCTTTTAGAA 2940
CTTACCCAGA AGGCAGTGTT AAATCTACGT AATGCTACCT ACGTAATGAT TTGACAGATT 3000
TTCGGAGCCT CATCCAGCTG TAAGATCCTG GAACGCTGAA CTGCCATAGG CTTACTTGAT 3060
GACTGTTGTC AGCCCCAGAG ATGGGTTCAT ACAGTTCTTA GGATTTCAGC TCGTCAGGAG 3120
TGTGATGACC TCACGATATT TTTAAGCCTT TAAGCAGTGT ATATAGTTGA GCTCTGTCAG 3180
CTCAGTCGCA TGCTCTCTGG AGATGCTTGG ATGAGAGGCG TTTACGTGCT GTAATCACAC 3240
AGTGTGACTC TTCTAAACTC ATCCACCCTT TGAACTGGCT GGAGGAAGTC ACCTTATTTT 3300
AAGAGAAAGT TCCTTGTCAG GTCAGGGCCA GGGGCATTCC TGTGTTCAGT CGCTATAGCT 3360
CCTCCCTCTT GTGTTCTACT TACTGAGTCT CTTAGAAAGA AAGCACAGAA GCAAGCTTTG 3420
AGCTCAAACG TTGACTTTCT TACAAACTAT ACATGAAGAA ATACACCAAA ATTTTACATT 3480
AAAGATTTAG AAATTAGTAG AACCTGTCCC TAAATTAGAT AGCTATATGT AAATGTGTAT 3540
GCATACATAC CATATATGGC CAAACATGGA ACTACCTCAC TAAAGCAACA TTTCCAGCAA 3600
TTACTATTCT TTGTTACATT TACACCAAGA TATTCAGAAT CTTTGTTGTA CAAAAGTTCT 3660
GTAACAGTGG GTGGCGGAAA AAGGCCCAAG TGTGAGTTCA CAGTTTATAG GTGGTGAAAA 3720
CGAGGCCTTA CTGCTGTAGT CTATATTTAA ATGTTCATGG TAACACATTT GAAGCAATAA 3780
ATGGCTTAAT TAAATGCCTA 3801
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0341--Growth regulation
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
--
Interpro

IPR028651--ING_fam
IPR024610--ING_N_histone_binding
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF12998--ING
Gene Ontology

GO:0005737--C:cytoplasm
GO:0035267--C:NuA4 histone acetyltransferase complex
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0032777--C:Piccolo NuA4 histone acetyltransferase complex
GO:0000812--C:Swr1 complex
GO:0004402--F:histone acetyltransferase activity
GO:0035064--F:methylated histone binding
GO:0008270--F:zinc ion binding
GO:0043968--P:histone H2A acetylation
GO:0043967--P:histone H4 acetylation
GO:0043065--P:positive regulation of apoptotic process
GO:0040008--P:regulation of growth
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Ran-0034 ENSRNOP00000007476.4 Rattus norvegicus 99 0.0 709
WERAM-Mup-0077 ENSMPUP00000006997.1 Mustela putorius furo 95 0.0 691
WERAM-Bot-0150 ENSBTAP00000021725.5 Bos taurus 95 0.0 686
WERAM-Ova-0192 ENSOARP00000019466.1 Ovis aries 94 0.0 677
WERAM-Caf-0038 ENSCAFP00000005192.3 Canis familiaris 95 0.0 674
WERAM-Fec-0200 ENSFCAP00000020713.1 Felis catus 94 0.0 674
WERAM-Orc-0015 ENSOCUP00000001622.3 Oryctolagus cuniculus 95 0.0 672
WERAM-Aim-0073 ENSAMEP00000006322.1 Ailuropoda melanoleuca 95 0.0 672
WERAM-Ict-0046 ENSSTOP00000003622.2 Ictidomys tridecemlineatus 95 0.0 672
WERAM-Eqc-0045 ENSECAP00000006448.1 Equus caballus 95 0.0 672
WERAM-Myl-0177 ENSMLUP00000014873.2 Myotis lucifugus 95 0.0 671
WERAM-Chs-0132 ENSCSAP00000006990.1 Chlorocebus sabaeus 94 0.0 669
WERAM-Dan-0010 ENSDNOP00000001153.3 Dasypus novemcinctus 95 0.0 669
WERAM-Sus-0124 ENSSSCP00000017603.2 Sus scrofa 94 0.0 669
WERAM-Soa-0122 ENSSARP00000011714.1 Sorex araneus 93 0.0 667
WERAM-Paa-0124 ENSPANP00000004010.1 Papio anubis 94 0.0 667
WERAM-Poa-0165 ENSPPYP00000020124.2 Pongo abelii 95 0.0 666
WERAM-Pat-0164 ENSPTRP00000033606.4 Pan troglodytes 95 0.0 666
WERAM-Nol-0127 ENSNLEP00000014397.1 Nomascus leucogenys 95 0.0 666
WERAM-Hos-0029 ENSP00000320566.5 Homo sapiens 95 0.0 666
WERAM-Loa-0213 ENSLAFP00000019667.1 Loxodonta africana 94 0.0 666
WERAM-Otg-0055 ENSOGAP00000003761.2 Otolemur garnettii 95 0.0 666
WERAM-Ptv-0107 ENSPVAP00000009534.1 Pteropus vampyrus 94 0.0 661
WERAM-Tut-0185 ENSTTRP00000015382.1 Tursiops truncatus 94 0.0 658
WERAM-Chh-0044 ENSCHOP00000005027.1 Choloepus hoffmanni 93 0.0 657
WERAM-Cap-0197 ENSCPOP00000018334.1 Cavia porcellus 95 0.0 654
WERAM-Sah-0147 ENSSHAP00000015324.1 Sarcophilus harrisii 91 0.0 653
WERAM-Caj-0180 ENSCJAP00000031565.1 Callithrix jacchus 94 0.0 649
WERAM-Prc-0118 ENSPCAP00000010407.1 Procavia capensis 91 0.0 641
WERAM-Pes-0054 ENSPSIP00000007361.1 Pelodiscus sinensis 88 0.0 636
WERAM-Lac-0111 ENSLACP00000013747.2 Latimeria chalumnae 84 0.0 632
WERAM-Anc-0074 ENSACAP00000006929.2 Anolis carolinensis 88 2e-174 609
WERAM-Ten-0032 ENSTNIP00000006039.1 Tetraodon nigroviridis 80 9e-171 597
WERAM-Asm-0105 ENSAMXP00000010482.1 Astyanax mexicanus 81 3e-168 588
WERAM-Leo-0165 ENSLOCP00000019441.1 Lepisosteus oculatus 84 2e-167 586
WERAM-Tar-0017 ENSTRUP00000003694.1 Takifugu rubripes 80 3e-167 585
WERAM-Orn-0086 ENSONIP00000009520.1 Oreochromis niloticus 81 2e-164 576
WERAM-Dar-0072 ENSDARP00000031200.5 Danio rerio 78 3e-164 575
WERAM-Anp-0009 ENSAPLP00000001673.1 Anas platyrhynchos 85 2e-163 572
WERAM-Tag-0065 ENSTGUP00000004796.1 Taeniopygia guttata 88 1e-161 566
WERAM-Gam-0190 ENSGMOP00000018296.1 Gadus morhua 79 5e-161 564
WERAM-Ora-0058 ENSOANP00000008990.3 Ornithorhynchus anatinus 88 4e-160 561
WERAM-Xim-0108 ENSXMAP00000009576.1 Xiphophorus maculatus 82 2e-159 559
WERAM-Ect-0116 ENSETEP00000013115.1 Echinops telfairi 85 3e-159 558
WERAM-Pof-0248 ENSPFOP00000029114.1 Poecilia formosa 81 1e-158 556
WERAM-Xet-0148 ENSXETP00000049164.2 Xenopus tropicalis 76 1e-157 553
WERAM-Gaa-0006 ENSGACP00000000841.2 Gasterosteus aculeatus 78 9e-157 550
WERAM-Meg-0093 ENSMGAP00000008949.1 Meleagris gallopavo 88 4e-154 541
WERAM-Fia-0124 ENSFALP00000010408.1 Ficedula albicollis 87 1e-153 540
WERAM-Gaga-0094 ENSGALP00000014665.4 Gallus gallus 89 1e-153 540
WERAM-Mae-0124 ENSMEUP00000012568.1 Macropus eugenii 78 2e-151 532
WERAM-Gog-0044 ENSGGOP00000004268.2 Gorilla gorilla 97 9e-113 404
WERAM-Tas-0001 ENSTSYP00000000124.1 Tarsius syrichta 85 5e-94 342
WERAM-Ocp-0149 ENSOPRP00000015445.1 Ochotona princeps 75 6e-77 285
WERAM-Cis-0005 ENSCSAVP00000000824.1 Ciona savignyi 58 3e-52 203
WERAM-Cii-0019 ENSCINP00000007229.3 Ciona intestinalis 59 7e-51 198
WERAM-Drm-0038 FBpp0074385 Drosophila melanogaster 62 2e-42 171
WERAM-Pem-0004 ENSPMAP00000000234.1 Petromyzon marinus 88 2e-39 160
WERAM-Arl-0064 fgenesh2_kg.3__ 2635__ AT3G24010.1 Arabidopsis lyrata 65 2e-27 121
WERAM-Art-0077 AT3G24010.1 Arabidopsis thaliana 64 6e-27 119
WERAM-Orla-0129 ENSORLP00000015380.1 Oryzias latipes 72 6e-26 115
WERAM-Thc-0053 EOY05425 Theobroma cacao 64 7e-26 115
WERAM-Bro-0124 Bo7g036450.1 Brassica oleracea 65 8e-26 115
WERAM-Brr-0075 Bra015016.1-P Brassica rapa 65 8e-26 115
WERAM-Brd-0037 BRADI1G75507.1 Brachypodium distachyon 65 1e-25 115
WERAM-Sot-0036 PGSC0003DMT400030294 Solanum tuberosum 64 2e-25 114
WERAM-Orbr-0038 OB03G13430.1 Oryza brachyantha 65 2e-25 114
WERAM-Sol-0119 Solyc09g091190.2.1 Solanum lycopersicum 64 2e-25 114
WERAM-Lep-0035 LPERR03G03140.1 Leersia perrieri 65 2e-25 114
WERAM-Mod-0067 ENSMODP00000010747.1 Monodelphis domestica 65 2e-25 114
WERAM-Tub-0041 ENSTBEP00000005072.1 Tupaia belangeri 65 2e-25 114
WERAM-Mim-0061 ENSMICP00000006050.1 Microcebus murinus 65 2e-25 114
WERAM-Mam-0158 ENSMMUP00000022340.2 Macaca mulatta 65 2e-25 114
WERAM-Orp-0029 OPUNC03G03150.1 Oryza punctata 69 3e-25 113
WERAM-Met-0017 KEH41192 Medicago truncatula 70 4e-25 113
WERAM-Vip-0056 ENSVPAP00000005332.1 Vicugna pacos 71 5e-25 112
WERAM-Prp-0084 EMJ28765 Prunus persica 64 6e-25 112
WERAM-Ere-0110 ENSEEUP00000011689.1 Erinaceus europaeus 65 6e-25 112
WERAM-Dio-0155 ENSDORP00000014378.1 Dipodomys ordii 71 7e-25 112
Created Date 25-Jun-2016