WERAM Information
Tag | Content | ||||||||||||
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WERAM ID | WERAM-Mum-0096 | ||||||||||||
Ensembl Protein ID | ENSMUSP00000031215.8 | ||||||||||||
Uniprot Accession | Q91Y44; BRDT_MOUSE; G3X8Z8; Q59HJ4 | ||||||||||||
Genbank Protein ID | NP_001073342.1; NP_473395.2 | ||||||||||||
Protein Name | Bromodomain testis-specific protein | ||||||||||||
Genbank Nucleotide ID | NM_001079873.1; NM_054054.2 | ||||||||||||
Gene Name | BRDT;Fsrg3 | ||||||||||||
Ensembl Information |
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Details |
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Status | Reviewed | ||||||||||||
Classification |
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Organism | Mus musculus | ||||||||||||
NCBI Taxa ID | 10090 | ||||||||||||
Functional Description (View) |
Testis-specific chromatin protein that specifically binds histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and H4K8ac, respectively) and plays a key role in spermatogenesis. Required in late pachytene spermatocytes: plays a role in meiotic and post-meiotic cells by binding to acetylated histones at the promoter of specific meiotic and post-meiotic genes, facilitating their activation at the appropriate time. In the post-meiotic phase of spermatogenesis, binds to hyperacetylated histones and participates in their general removal from DNA. Also acts as a component of the splicing machinery in pachytene spermatocytes and round spermatids and participates in 3'-UTR truncation of specific mRNAs in post-meiotic spermatids. Required for chromocenter organization, a structure comprised of peri-centromeric heterochromatin. | ||||||||||||
Domain Profile | Ac_Reader Bromodomain BROMO.txt 2 ehevsepFrepvdpq.leipdYydiikePmdLstikerleegnYsspeefvkDvrlifnNakaynenkssv 71 |
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Protein Sequence (Fasta) | MSLPSRQTAI VNPPPPEYIN TKKSGRLTNQ LQFLQRVVLK ALWKHGFSWP FQQPVDAVKL 60 KLPDYYTIIK TPMDLNTIKK RLENKYYEKA SECIEDFNTM FSNCYLYNKT GDDIVVMAQA 120 LEKLFMQKLS QMPQEEQVVG GKERIKKDIQ QKIAVSSAKE QIPSKAAENV FKRQEIPSGL 180 PDISLSPLNM AQEAPPICDS QSLVQITKGV KRRADTTTPT TSIAKASSES PPTLRETKPV 240 NMPVKENTVK NVLPDSQQQH KVLKTVKVTE QLKHCSEILK EMLAKKHLPY AWPFYNPVDA 300 DALGLHNYYD VVKNPMDLGT IKGKMDNQEY KDAYEFAADV RLMFMNCYKY NPPDHEVVAM 360 ARTLQDVFEL HFAKIPDEPI ESMHACHLTT NSAQALSRES SSEASSGDAS SEDSEDERVQ 420 HLAKLQEQLN AVHQQLQVLS QVPLRKLKKK NEKSKRAPKR KKVNNRDENP RKKPKQMKQK 480 EKAKINQPKK KKPLLKSEEE DNAKPMNYDE KRQLSLDINK LPGDKLGRIV HIIQSREPSL 540 RNSNPDEIEI DFETLKASTL RELEKYVLAC LRKRSLKPQA KKVVRSKEEL HSEKKLELER 600 RLLDVNNQLN CRKRQTKRPA KVEKPPPPPP PPPPPPPPPE LASGSRLTDS SSSSGSGSGS 660 SSSSSGSSSS SSSSGSASSS SDSSSSDSSD SEPEIFPKFT GVKQNDLPPK ENIKQIQSSV 720 QDITSAEAPL AQQSTAPCGA PGKHSQQMLG CQVTQHLQAT ENTASVQTQP LSGDCKRVLL 780 GPPVVHTSAE SLTVLEPECH APAQKDIKIK NADSWKSLGK PVKASSVLKS SDELFNQFRK 840 AAIEKEVKAR TQEQMRKHLE HNAKDPKVSQ ENQREPGSGL TLESLSSKVQ DKSLEEDQSE 900 QQPPSEAQDV SKLWLLKDRN LAREKEQERR RREAMAGTID MTLQSDIMTM FENNFD 956 |
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Nucleotide Sequence (Fasta) | GTCCCATAAA GGCGCCAGTC GCTGGCTGCT GACAGCCGCC ATCCGGGCGA GAGCTGGCGG 60 CCACCGGTGG AGAACCGGGA GCGACGGTCC TGCACTGCTT CATCTAGTGC AAACTGAAAG 120 GGTGATCGGA TAAGGCCCTT TCCTAAGAGG AATTTGTAGA CTTTTCCTGC TAAGACCTCA 180 ATTTGTATTT TTGAAGAACA GAAAGAAATT CTGTGACGTG TTGAAATAAT TTAAACCATC 240 TAAGACCAAG ACACACATAA TGAAGCAATG CATACTATTT ATATAAAAAA GGACATGTCC 300 TCTTAGACAA CTTTAAAATA CCAGGATCCG AAGTGGTTGA GAATGTCTCT GCCAAGTCGA 360 CAAACAGCTA TTGTTAACCC CCCTCCACCA GAGTACATAA ACACTAAGAA GAGTGGGCGG 420 TTGACGAATC AGCTGCAGTT CCTACAGAGG GTTGTGCTGA AGGCCCTGTG GAAGCACGGC 480 TTCTCTTGGC CTTTCCAACA GCCGGTGGAC GCCGTGAAAC TAAAGCTGCC TGACTATTAC 540 ACCATCATAA AAACCCCAAT GGATTTAAAT ACAATTAAGA AGCGGTTGGA AAATAAGTAT 600 TATGAGAAGG CTTCCGAATG CATAGAAGAC TTCAACACAA TGTTCTCAAA CTGCTACTTA 660 TACAACAAGA CTGGAGATGA CATTGTTGTT ATGGCCCAAG CTCTAGAGAA GTTATTTATG 720 CAGAAATTAT CTCAGATGCC ACAAGAAGAG CAAGTTGTGG GTGGTAAGGA GAGAATAAAG 780 AAAGATATCC AACAAAAGAT AGCGGTTTCC TCTGCTAAGG AACAAATCCC CTCCAAAGCG 840 GCAGAGAATG TCTTTAAGCG GCAAGAGATT CCTTCTGGGC TTCCTGACAT CTCTCTCTCG 900 CCCTTAAACA TGGCACAAGA AGCTCCCCCG ATCTGTGACT CGCAGTCTCT GGTCCAAATT 960 ACAAAGGGTG TGAAGAGGCG AGCAGACACA ACAACTCCTA CCACTTCCAT AGCTAAAGCA 1020 AGTAGCGAAT CTCCTCCGAC ACTTAGAGAA ACAAAGCCAG TGAACATGCC AGTAAAAGAA 1080 AATACAGTAA AGAACGTTTT GCCAGACTCT CAGCAACAAC ACAAAGTTTT AAAAACAGTC 1140 AAAGTAACGG AGCAATTAAA GCACTGCAGC GAGATTCTTA AAGAAATGCT TGCCAAGAAA 1200 CATTTGCCGT ATGCATGGCC CTTCTATAAT CCTGTGGATG CTGATGCTTT GGGACTCCAC 1260 AACTACTATG ACGTTGTCAA AAATCCCATG GATCTCGGAA CGATCAAGGG GAAAATGGAC 1320 AATCAAGAAT ATAAGGATGC ATATGAATTT GCTGCAGATG TCAGACTGAT GTTCATGAAC 1380 TGTTACAAGT ATAATCCTCC CGATCATGAA GTTGTGGCGA TGGCTCGGAC CCTTCAGGAT 1440 GTTTTTGAAC TACATTTTGC CAAGATTCCC GATGAACCTA TTGAGAGTAT GCATGCATGC 1500 CACCTTACAA CAAACAGTGC ACAAGCCCTC AGCAGAGAAA GCAGCAGCGA GGCCTCCTCG 1560 GGGGACGCCT CTTCTGAAGA CTCTGAGGAT GAACGAGTGC AGCATCTTGC CAAGCTTCAG 1620 GAGCAGCTTA ATGCTGTTCA TCAGCAGCTG CAAGTTCTGT CCCAAGTTCC ATTACGTAAG 1680 CTGAAGAAAA AGAATGAGAA GTCCAAAAGG GCGCCAAAAA GGAAAAAGGT TAATAACAGA 1740 GATGAAAACC CAAGGAAAAA GCCTAAGCAA ATGAAGCAAA AGGAGAAGGC CAAAATCAAT 1800 CAACCAAAGA AGAAGAAGCC GCTTTTGAAA TCGGAAGAGG AAGACAATGC GAAGCCTATG 1860 AACTACGATG AGAAAAGGCA GCTGAGCTTG GACATAAACA AACTGCCTGG AGACAAGCTT 1920 GGTCGAATAG TTCACATAAT ACAGTCAAGG GAGCCTTCCC TGAGAAACTC CAACCCGGAC 1980 GAGATCGAGA TCGACTTTGA GACCCTGAAG GCATCCACAC TTAGAGAACT GGAGAAGTAT 2040 GTCCTGGCCT GTCTGAGGAA GAGGTCGCTG AAGCCCCAAG CAAAGAAGGT TGTCAGGTCT 2100 AAGGAGGAGC TCCATTCTGA AAAAAAGCTG GAGCTGGAGA GGCGGTTGCT GGACGTCAAC 2160 AATCAGCTGA ATTGTAGGAA ACGGCAAACG AAACGTCCAG CAAAAGTGGA GAAGCCGCCC 2220 CCGCCCCCGC CCCCGCCCCC GCCCCCGCCG CCTCCCCCGG AGCTGGCCAG TGGGTCTCGC 2280 CTGACCGACA GCAGCAGCAG CAGCGGCAGC GGCAGCGGCA GCAGCAGCAG CAGCAGCGGC 2340 AGCAGCAGCA GCAGCAGCTC CTCGGGGTCC GCGAGCAGCA GCAGCGACTC GAGCTCCTCC 2400 GACAGCAGCG ATTCTGAACC AGAAATATTT CCTAAATTTA CTGGAGTAAA ACAGAATGAT 2460 TTACCTCCAA AAGAAAATAT AAAGCAGATA CAATCTTCTG TGCAAGACAT AACCTCTGCT 2520 GAAGCTCCCC TTGCTCAGCA GAGCACAGCA CCATGCGGAG CCCCAGGGAA GCACTCCCAG 2580 CAGATGCTTG GTTGCCAAGT GACACAGCAT CTGCAGGCCA CAGAGAACAC TGCATCTGTG 2640 CAGACTCAGC CTCTTTCAGG TGATTGCAAG CGAGTATTGC TTGGCCCCCC TGTGGTGCAC 2700 ACCTCTGCTG AGAGCCTCAC AGTGCTGGAG CCAGAATGCC ATGCTCCCGC GCAGAAGGAT 2760 ATAAAGATTA AGAATGCAGA CTCTTGGAAA AGTTTAGGGA AGCCAGTGAA AGCATCAAGT 2820 GTACTGAAGT CTTCAGATGA GCTTTTCAAC CAGTTTAGAA AAGCTGCAAT AGAAAAGGAG 2880 GTAAAGGCCC GGACACAGGA GCAGATGCGG AAACACCTGG AGCATAATGC GAAGGACCCA 2940 AAAGTATCTC AAGAAAATCA GAGGGAGCCT GGAAGTGGAT TGACTCTAGA ATCTTTATCA 3000 AGTAAAGTGC AAGATAAGTC TCTTGAAGAA GATCAGAGTG AACAGCAGCC ACCGTCGGAA 3060 GCTCAAGACG TAAGCAAGCT CTGGCTTCTC AAAGACCGGA ATCTAGCGAG GGAGAAAGAG 3120 CAAGAGCGCA GGAGAAGAGA AGCAATGGCG GGTACCATTG ATATGACTCT TCAAAGTGAC 3180 ATTATGACAA TGTTTGAAAA TAACTTTGAT TAAAACTCAG TTTGTAAATT AACCCTCAAC 3240 TTTAAATGAA AGGTAAAAGT GTTTACAGTG GGCGTGGTTA AAGTGGTTAC TTTAAACACC 3300 AGAATGTCAA TCACTGATTG TGTTCTGACT GCCCTAAATA ATTTTTCATT TACATTTTAA 3360 TAAATATGTT CTTTTAATGA CATAATTGAT AAAATGTTTT ATAATTTTGA CCTCTGAAAG 3420 TGGATAGATT TTATTCATCC TAAAGAGGAC TGTCAGTGAT GTAATATAGT CCTGATCTAA 3480 GTCTAAAAGG GATCATCAGA TTGAAAACAA ATGAAGAATA CATAAAAGTA TATAAAACAC 3540 GTTTTGTTGA GATTTTAACT TTTGTTTTTT GTCTAAACCT GTTTGTTGGT TAGTTGGTTT 3600 GTGTCCTTGT TTGAGACAGG GTCTCATATA CTCAGGCTGG CTTTGGTGAA CTCAACATGT 3660 AGCCAAGGCT GGCCTTGATC TCCTGATTCT CCTGCCCTCA GCTCTCAAGT ACTGGACTCC 3720 AGAAGTGTGT CTTCATGCCT GGCTGAGTTG TTAACTTTTC AAAGAGATAT GTGTCTGCTG 3780 TCAGAATTGT AACAGAACTT CTAACAAGAA TACTTGGTTT CCATGTGAGT CACAGTGTGT 3840 CAGATTCTCT GCTAGTTCCA TGTTTAAATT CCATACTGCC TTTTGTTTTA AAGTAATATT 3900 AGCTATGATT TGAAAGGTGT TAAATTTTAA GCAAAGTAAT AGTAAATATT GTGTATACAA 3960 GCTTCTGTGG GAATGTGTCA GACATTTCTT AAAATGTGTA GGTGATAGCA ATGAATATTT 4020 GCCTAACCAG GGGAAATTAT AGCCTATGAA ACATTGATGT TTTGTCATTT TTCAAACTGC 4080 ATGCATGTCT AACCATATGT AATCTTTTTT AAAATTTTAA ACCTTTGAAC ATTTGAAATA 4140 TAACCTGATT AAGGCAATGC TGTGATCTAA AGTACAAACT CAGTGTGTGT CCAGACAGGG 4200 AAGTGCACAC CTGCTGTCCA GACAGGGCAG TGCACACCTG CTATGCAGAC AGGGCAGTGC 4260 ACATCTGCTG TCCAGACAGG GCAGTGCACA CCTGCTATGC AGACAGGGCA GTGCACACCT 4320 GCTGTCCAGA CAGGGCAGTG CACACCTGCT ATGTAGACAG GGCAGTGCAC ACCTGCTGTC 4380 CAGACAGGGC AGTGCACACC TGCTGTCCAG ACAGGGCAGT GCACACCTGC TGTCCAGACA 4440 GGGCAGTGAA CACCTGCTGT CCAGACAGGG CAGTGCACAC CTGCTGTAAT TCCAGTATTT 4500 GGGGGGCAGA GGCAGAGAAG GAGTCACTGC TGATAACTCA AGACCAGCCT GGTTCACATA 4560 GCAATCTTCA GATTCTGGTC ATAGCCAGAC CTCCTTGATT GAGAAGAACC AAGAAAGAGA 4620 GAGAGAAAGA GAGTAAGAAG ATGGTATTGC TTTCAGGAAA CATTGCTTTC AGGAAACAAC 4680 CAGAATTAAA GTGATAGATA TTTTGTTGTA CCTATTTTCT ACTTTTTAAT TAAAAACTTT 4740 ATATG 4746 |
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Sequence Source | Ensembl | ||||||||||||
Keyword | KW-0002--3D-structure |
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Interpro | IPR031354--BRD4_CDT |
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PROSITE | |||||||||||||
Pfam | PF17035--BET |
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Gene Ontology | GO:0005634--C:nucleus |
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Orthology | |||||||||||||
Created Date | 25-Jun-2016 |