WERAM Information

Tag Content
WERAM ID WERAM-Hos-0132
Ensembl Protein ID ENSP00000384051.1
Uniprot Accession Q58F21; BRDT_HUMAN; A6NF68; B7Z811; B7Z890; B7ZAX7; D3DT32; O14789; Q05DQ4; Q6P5T1; Q7Z4A6; Q8IWI6
Genbank Protein ID NP_001229734.2; NP_001229735.2; NP_001229736.2; NP_001229737.2; NP_001229739.2; NP_001717.3; NP_997072.2; XP_006710916.1; XP_006710917.1; XP_006710918.1; XP_006710919.1; XP_006710920.1; XP_011540334.1; XP_011540335.1; XP_011540336.1; XP_011540337.1; XP_011540338.1
Protein Name Bromodomain testis-specific protein
Genbank Nucleotide ID NM_001242805.2; NM_001242806.2; NM_001242807.2; NM_001242808.2; NM_001242810.2; NM_001726.4; NM_207189.3; XM_006710853.2; XM_006710854.2; XM_006710855.2; XM_006710856.2; XM_006710857.2; XM_011542032.1; XM_011542033.1; XM_011542034.1; XM_011542035.1; XM_011542036.1
Gene Name BRDT;BRD6
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000137948.18 ENST00000402388.1 ENSP00000384051.1
ENSG00000137948.18 ENST00000362005.7 ENSP00000354568.3
ENSG00000137948.18 ENST00000370389.6 ENSP00000359416.2
ENSG00000137948.18 ENST00000394530.7 ENSP00000378038.3
ENSG00000137948.18 ENST00000399546.6 ENSP00000387822.2
ENSG00000137948.18 ENST00000423434.5 ENSP00000396351.1
ENSG00000137948.18 ENST00000427104.5 ENSP00000400002.1
ENSG00000137948.18 ENST00000426141.5 ENSP00000404969.1
ENSG00000137948.18 ENST00000448194.5 ENSP00000410587.1
ENSG00000137948.18 ENST00000450792.5 ENSP00000414349.1
ENSG00000137948.18 ENST00000440509.5 ENSP00000416714.1
ENSG00000137948.18 ENST00000552654.1 ENSP00000446599.1
ENSG00000137948.18 ENST00000548992.5 ENSP00000447394.1
Details
Type Family Domain Substrates AA References (PMIDs)
Ac_Reader Bromodomain Bromodomain H2BK12; H2BK15; H3K9; H3K14; H3K18; H3K23; H4K5; H4K8; H4K12; H4K16 K 22464331
Status Reviewed
Classification
Type Family E-value Score Start End
Ac_Reader Bromodomain 1.10e-52 178.3 45 358
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)		 Testis-specific chromatin protein that specifically binds histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and H4K8ac, respectively) and plays a key role in spermatogenesis. Required in late pachytene spermatocytes: plays a role in meiotic and post-meiotic cells by binding to acetylated histones at the promoter of specific meiotic and post-meiotic genes, facilitating their activation at the appropriate time. In the post-meiotic phase of spermatogenesis, binds to hyperacetylated histones and participates in their general removal from DNA. Also acts as a component of the splicing machinery in pachytene spermatocytes and round spermatids and participates in 3'-UTR truncation of specific mRNAs in post-meiotic spermatids. Required for chromocenter organization, a structure comprised of peri-centromeric heterochromatin.
Domain Profile
  Ac_Reader Bromodomain
          BROMO.txt   2 ehevsepFrepvdpq.leipdYydiikePmdLstikerleegnYsspeefvkDvrlifnNakaynenkssv 71 
                        +h++s+pF++pvd+  l++pdYy+iik+PmdL+tik+rle+++Y +++e+++D++ +f+N++ yn++++++
  ENSP00000384051.1  45 KHSFSWPFQRPVDAVkLQLPDYYTIIKNPMDLNTIKKRLENKYYAKASECIEDFNTMFSNCYLYNKPGDDI 115
                        799****************************************************************9997 PP
          BROMO.txt   5 vsepFrepvdpq.leipdYydiikePmdLstikerleegnYsspeefvkDvrlifnNakaynenkssv 71 
                        +++pF +pvd + l +++Yyd++k+PmdL tike++++++Y+++ +f++Dvrl+f N+++yn+++++v
  ENSP00000384051.1 291 YAWPFYNPVDVNaLGLHNYYDVVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNPPDHEV 358
                        79***************************************************************998 PP
Protein Sequence
(Fasta)		MSLPSRQTAI IVNPPPPEYI NTKKNGRLTN QLQYLQKVVL KDLWKHSFSW PFQRPVDAVK 60
LQLPDYYTII KNPMDLNTIK KRLENKYYAK ASECIEDFNT MFSNCYLYNK PGDDIVLMAQ 120
ALEKLFMQKL SQMPQEEQVV GVKERIKKGT QQNIAVSSAK EKSSPSATEK VFKQQEIPSV 180
FPKTSISPLN VVQGASVNSS SQTAAQVTKG VKRKADTTTP ATSAVKASSE FSPTFTEKSV 240
ALPPIKENMP KNVLPDSQQQ YNVVKTVKVT EQLRHCSEIL KEMLAKKHFS YAWPFYNPVD 300
VNALGLHNYY DVVKNPMDLG TIKEKMDNQE YKDAYKFAAD VRLMFMNCYK YNPPDHEVVT 360
MARMLQDVFE THFSKIPIEP VESMPLCYIK TDITETTGRE NTNEASSEGN SSDDSEDERV 420
KRLAKLQEQL KAVHQQLQVL SQVPFRKLNK KKEKSKKEKK KEKVNNSNEN PRKMCEQMRL 480
KEKSKRNQPK KRKQQFIGLK SEDEDNAKPM NYDEKRQLSL NINKLPGDKL GRVVHIIQSR 540
EPSLSNSNPD EIEIDFETLK ASTLRELEKY VSACLRKRPL KPPAKKIMMS KEELHSQKKQ 600
ELEKRLLDVN NQLNSRKRQT KSDKTQPSKA VENVSRLSES SSSSSSSSES ESSSSDLSSS 660
DSSDSESEMF PKFTEVKPND SPSKENVKKM KNECIPPEGR TGVTQIGYCV QDTTSANTTL 720
VHQTTPSHVM PPNHHQLAFN YQELEHLQTV KNISPLQILP PSGDSEQLSN GITVMHPSGD 780
SDTTMLESEC QAPVQKDIKI KNADSWKSLG KPVKPSGVMK SSDELFNQFR KAAIEKEVKA 840
RTQELIRKHL EQNTKELKAS QENQRDLGNG LTVESFSNKI QNKCSGEEQK EHQQSSEAQD 900
KSKLWLLKDR DLARQKEQER RRREAMVGTI DMTLQSDIMT MFENNFD 947
Nucleotide Sequence
(Fasta)		AAGAGCATTT TAAGAATCAT AATAGTTCAG TGCAGATGTT CCTGGGAGGT CAAGTTAAGA 60
GTCAAAAATA ATTCATTAGA TTTAACAATT TAGCATGGAC ATGTACTTGT AGACAGGATT 120
CAAAGCAGTT AAGAATGTCT CTGCCAAGTC GACAAACAGC TATTATTGTT AACCCTCCTC 180
CACCAGAATA TATAAATACT AAGAAAAATG GGCGATTGAC AAATCAACTT CAGTATCTAC 240
AAAAAGTTGT CCTAAAGGAT TTATGGAAGC ATAGTTTTTC ATGGCCCTTT CAACGTCCTG 300
TGGATGCTGT GAAACTACAG TTGCCTGATT ATTATACCAT TATAAAAAAC CCAATGGATT 360
TAAATACAAT TAAGAAGCGC TTGGAGAATA AATATTATGC GAAGGCTTCA GAATGTATAG 420
AAGACTTCAA TACAATGTTC TCAAATTGTT ATTTATATAA CAAGCCTGGA GATGACATTG 480
TTCTTATGGC ACAAGCTCTA GAGAAGCTGT TTATGCAGAA ATTATCTCAG ATGCCACAAG 540
AAGAGCAAGT TGTGGGTGTT AAGGAAAGAA TCAAGAAAGG CACTCAACAG AATATAGCTG 600
TTTCTTCTGC TAAAGAAAAA TCATCACCCA GCGCAACAGA AAAAGTATTT AAGCAGCAAG 660
AAATTCCTTC TGTATTTCCT AAGACATCTA TTTCTCCCTT GAACGTGGTA CAGGGAGCTT 720
CAGTCAACTC CAGTTCACAA ACTGCGGCCC AAGTTACAAA AGGTGTGAAG AGGAAAGCAG 780
ATACAACAAC TCCTGCAACT TCAGCAGTTA AAGCAAGTAG TGAATTTTCT CCAACATTCA 840
CAGAAAAATC AGTGGCACTG CCACCTATAA AAGAAAATAT GCCAAAGAAT GTTTTGCCAG 900
ATTCTCAGCA ACAATATAAT GTTGTGAAGA CTGTTAAAGT AACTGAACAA TTAAGGCACT 960
GTAGTGAGAT TCTTAAAGAA ATGCTTGCAA AGAAACATTT TTCATATGCA TGGCCCTTTT 1020
ATAATCCTGT TGACGTTAAT GCTTTGGGAC TCCATAACTA CTATGACGTT GTCAAAAATC 1080
CGATGGATCT TGGAACTATT AAGGAGAAAA TGGATAACCA AGAATATAAG GATGCATACA 1140
AATTTGCGGC AGATGTTAGA TTAATGTTCA TGAATTGCTA CAAGTACAAT CCTCCAGATC 1200
ACGAAGTTGT GACAATGGCA AGAATGCTTC AGGATGTTTT CGAAACGCAT TTTTCAAAGA 1260
TCCCGATTGA ACCTGTTGAG AGTATGCCTT TATGTTACAT CAAAACAGAT ATCACAGAAA 1320
CCACTGGTAG AGAGAACACT AATGAAGCCT CCTCTGAAGG GAACTCTTCT GATGATTCTG 1380
AAGATGAGCG AGTTAAGCGT CTTGCAAAGC TTCAGGAGCA GCTTAAAGCT GTACATCAAC 1440
AGCTCCAGGT TTTGTCCCAA GTACCTTTCC GTAAGCTAAA TAAAAAGAAA GAGAAGTCTA 1500
AAAAGGAAAA GAAAAAAGAA AAGGTTAATA ACAGCAATGA AAATCCAAGA AAAATGTGTG 1560
AGCAAATGAG GCTAAAGGAA AAGTCCAAGA GAAATCAGCC AAAGAAAAGG AAACAACAGT 1620
TCATTGGTCT AAAATCTGAA GATGAAGATA ATGCTAAACC TATGAACTAT GATGAGAAAA 1680
GGCAGTTAAG TCTGAATATA AACAAACTCC CTGGAGATAA ACTTGGGCGA GTAGTTCACA 1740
TAATACAATC AAGAGAGCCT TCTCTGAGCA ATTCCAATCC TGATGAGATA GAGATAGACT 1800
TTGAAACACT GAAAGCATCA ACACTAAGAG AATTAGAAAA ATATGTTTCG GCATGTCTAA 1860
GAAAGAGACC ATTAAAACCT CCTGCTAAGA AAATAATGAT GTCCAAAGAA GAACTTCACT 1920
CACAGAAAAA ACAGGAATTG GAAAAGCGGT TACTGGATGT TAATAATCAG TTAAATTCTA 1980
GAAAACGTCA AACAAAATCT GATAAAACGC AACCATCCAA AGCTGTTGAA AATGTTTCCC 2040
GACTGAGTGA GAGCAGCAGC AGCAGCAGCA GCTCATCAGA GTCTGAAAGT AGCAGCAGTG 2100
ACTTAAGCTC TTCAGACAGC AGTGATTCTG AATCAGAAAT GTTCCCTAAG TTTACAGAAG 2160
TAAAACCAAA TGATTCTCCT TCTAAAGAGA ATGTAAAGAA AATGAAGAAT GAATGCATAC 2220
CGCCTGAAGG AAGAACAGGC GTCACACAGA TAGGATATTG TGTGCAAGAC ACAACCTCTG 2280
CCAATACTAC CCTTGTTCAT CAGACCACAC CTTCACATGT AATGCCACCA AATCACCACC 2340
AATTAGCATT TAATTATCAA GAATTAGAAC ATTTACAGAC TGTGAAAAAC ATTTCACCTT 2400
TACAAATTCT GCCTCCCTCA GGTGATTCTG AACAGCTCTC AAATGGCATA ACTGTGATGC 2460
ATCCATCTGG TGATAGTGAC ACAACGATGT TAGAATCTGA ATGTCAAGCT CCTGTACAGA 2520
AGGATATAAA GATTAAGAAT GCAGATTCAT GGAAAAGTTT AGGCAAACCA GTGAAACCAT 2580
CAGGTGTAAT GAAATCCTCA GATGAGCTCT TCAACCAATT TAGAAAAGCA GCCATAGAAA 2640
AGGAAGTAAA AGCTCGGACA CAGGAACTCA TACGGAAGCA TTTGGAACAA AATACAAAGG 2700
AACTAAAAGC ATCTCAAGAA AATCAGAGGG ATCTTGGGAA TGGATTGACT GTAGAATCTT 2760
TTTCAAATAA AATACAAAAC AAGTGCTCTG GAGAAGAGCA GAAAGAACAT CAGCAGTCAT 2820
CAGAAGCTCA AGATAAATCC AAACTCTGGC TTCTCAAAGA CCGTGATTTA GCAAGGCAGA 2880
AAGAACAAGA GAGGAGGAGG AGAGAAGCAA TGGTGGGTAC CATTGATATG ACCCTTCAAA 2940
GTGACATTAT GACAATGTTT GAAAACAACT TTGATTAAAA CTCAGTTTTT AAATTAACCA 3000
TCAACTTAAA ATGAATGGTA AAAGATCAAA ATGCATATGG TAAAATGATT GCTTTCAGAT 3060
AACAAGATAC CAATCTTATA TTGTATTTTG ACTGCTCTAA AATGATTAAA CAGTTTTCAC 3120
TTACA 3126
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0010--Activator
KW-0025--Alternative splicing
KW-0103--Bromodomain
KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0221--Differentiation
KW-0469--Meiosis
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0744--Spermatogenesis
KW-0804--Transcription
KW-0805--Transcription regulation
--
Interpro

IPR031354--BRD4_CDT
IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR027353--NET_dom
PROSITE

PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS51525--NET
Pfam

PF17035--BET
PF17105--BRD4_CDT
PF00439--Bromodomain
Gene Ontology

GO:0005634--C:nucleus
GO:0042393--F:histone binding
GO:0070577--F:lysine-acetylated histone binding
GO:0003713--F:transcription coactivator activity
GO:0030154--P:cell differentiation
GO:0006338--P:chromatin remodeling
GO:0001207--P:histone displacement
GO:0007140--P:male meiosis
GO:0007141--P:male meiosis I
GO:0006397--P:mRNA processing
GO:0051039--P:positive regulation of transcription involved in meiotic cell cycle
GO:0043484--P:regulation of RNA splicing
GO:0008380--P:RNA splicing
GO:0007283--P:spermatogenesis
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Pat-0007 ENSPTRP00000001644.4 Pan troglodytes 99 0.0 1688
WERAM-Nol-0111 ENSNLEP00000012659.1 Nomascus leucogenys 95 0.0 1658
WERAM-Chs-0015 ENSCSAP00000016562.1 Chlorocebus sabaeus 95 0.0 1633
WERAM-Paa-0051 ENSPANP00000003567.1 Papio anubis 93 0.0 1632
WERAM-Poa-0009 ENSPPYP00000001343.1 Pongo abelii 93 0.0 1612
WERAM-Gog-0200 ENSGGOP00000018437.1 Gorilla gorilla 97 0.0 1567
WERAM-Caj-0188 ENSCJAP00000032249.2 Callithrix jacchus 87 0.0 1494
WERAM-Mam-0121 ENSMMUP00000018423.2 Macaca mulatta 96 0.0 1425
WERAM-Ict-0035 ENSSTOP00000002736.2 Ictidomys tridecemlineatus 82 0.0 1407
WERAM-Otg-0019 ENSOGAP00000000893.2 Otolemur garnettii 83 0.0 1368
WERAM-Eqc-0123 ENSECAP00000013753.1 Equus caballus 81 0.0 1340
WERAM-Mup-0046 ENSMPUP00000004278.1 Mustela putorius furo 80 0.0 1339
WERAM-Orc-0168 ENSOCUP00000015006.3 Oryctolagus cuniculus 79 0.0 1332
WERAM-Aim-0010 ENSAMEP00000000596.1 Ailuropoda melanoleuca 80 0.0 1323
WERAM-Ova-0171 ENSOARP00000017265.1 Ovis aries 80 0.0 1315
WERAM-Myl-0068 ENSMLUP00000005696.2 Myotis lucifugus 77 0.0 1260
WERAM-Dan-0098 ENSDNOP00000010335.3 Dasypus novemcinctus 76 0.0 1249
WERAM-Caf-0209 ENSCAFP00000029909.3 Canis familiaris 77 0.0 1234
WERAM-Fec-0165 ENSFCAP00000017154.1 Felis catus 77 0.0 1227
WERAM-Ptv-0051 ENSPVAP00000005427.1 Pteropus vampyrus 81 0.0 1181
WERAM-Chh-0100 ENSCHOP00000011481.1 Choloepus hoffmanni 71 0.0 1165
WERAM-Tut-0162 ENSTTRP00000013635.1 Tursiops truncatus 74 0.0 1156
WERAM-Ran-0018 ENSRNOP00000058256.2 Rattus norvegicus 67 0.0 1089
WERAM-Tas-0103 ENSTSYP00000010758.1 Tarsius syrichta 75 0.0 1001
WERAM-Tub-0073 ENSTBEP00000009277.1 Tupaia belangeri 83 0.0 904
WERAM-Mum-0096 ENSMUSP00000031215.8 Mus musculus 78 0.0 884
WERAM-Bot-0223 ENSBTAP00000004850.5 Bos taurus 80 0.0 881
WERAM-Mod-0096 ENSMODP00000014906.4 Monodelphis domestica 75 0.0 864
WERAM-Sah-0133 ENSSHAP00000014254.1 Sarcophilus harrisii 61 0.0 817
WERAM-Cap-0043 ENSCPOP00000003467.2 Cavia porcellus 70 0.0 797
WERAM-Lac-0022 ENSLACP00000003855.1 Latimeria chalumnae 53 0.0 741
WERAM-Pes-0007 ENSPSIP00000002650.1 Pelodiscus sinensis 52 0.0 733
WERAM-Mim-0130 ENSMICP00000013048.1 Microcebus murinus 82 0.0 724
WERAM-Dio-0165 ENSDORP00000015565.1 Dipodomys ordii 71 0.0 687
WERAM-Meg-0088 ENSMGAP00000008554.2 Meleagris gallopavo 49 0.0 646
WERAM-Xet-0059 ENSXETP00000049781.3 Xenopus tropicalis 47 0.0 633
WERAM-Anp-0129 ENSAPLP00000014301.1 Anas platyrhynchos 54 7e-171 598
WERAM-Vip-0103 ENSVPAP00000009601.1 Vicugna pacos 78 9e-170 595
WERAM-Ere-0066 ENSEEUP00000005482.1 Erinaceus europaeus 75 6e-169 592
WERAM-Gaga-0063 ENSGALP00000009694.4 Gallus gallus 56 3e-167 587
WERAM-Anc-0042 ENSACAP00000004581.3 Anolis carolinensis 55 3e-167 587
WERAM-Leo-0036 ENSLOCP00000005834.1 Lepisosteus oculatus 56 3e-164 576
WERAM-Fia-0029 ENSFALP00000001836.1 Ficedula albicollis 54 2e-163 574
WERAM-Ora-0005 ENSOANP00000000712.2 Ornithorhynchus anatinus 69 9e-160 561
WERAM-Loa-0127 ENSLAFP00000011699.3 Loxodonta africana 84 2e-158 557
WERAM-Prc-0094 ENSPCAP00000008495.1 Procavia capensis 49 9e-153 538
WERAM-Asm-0174 ENSAMXP00000017222.1 Astyanax mexicanus 52 4e-149 526
WERAM-Ten-0212 ENSTNIP00000021345.1 Tetraodon nigroviridis 46 9e-145 511
WERAM-Tar-0198 ENSTRUP00000040915.1 Takifugu rubripes 48 7e-143 505
WERAM-Dar-0221 ENSDARP00000130622.1 Danio rerio 49 3e-142 503
WERAM-Ect-0114 ENSETEP00000012589.1 Echinops telfairi 49 5e-142 503
WERAM-Orn-0225 ENSONIP00000024235.1 Oreochromis niloticus 40 9e-139 492
WERAM-Gaa-0037 ENSGACP00000005692.1 Gasterosteus aculeatus 48 1e-135 482
WERAM-Tag-0083 ENSTGUP00000005921.1 Taeniopygia guttata 47 5e-135 479
WERAM-Soa-0062 ENSSARP00000006154.1 Sorex araneus 47 2e-129 461
WERAM-Xim-0143 ENSXMAP00000011561.1 Xiphophorus maculatus 38 1e-127 455
WERAM-Pem-0081 ENSPMAP00000008773.1 Petromyzon marinus 46 4e-125 446
WERAM-Sus-0016 ENSSSCP00000001595.1 Sus scrofa 51 7e-123 439
WERAM-Orla-0148 ENSORLP00000017453.1 Oryzias latipes 44 1e-121 435
WERAM-Ocp-0078 ENSOPRP00000006813.1 Ochotona princeps 51 4e-119 426
WERAM-Pof-0204 ENSPFOP00000016934.2 Poecilia formosa 44 2e-118 424
WERAM-Gam-0180 ENSGMOP00000017708.1 Gadus morhua 41 5e-99 360
WERAM-Cii-0085 ENSCINP00000034825.1 Ciona intestinalis 44 6e-89 326
WERAM-Cis-0028 ENSCSAVP00000005883.1 Ciona savignyi 43 4e-77 287
Created Date 25-Jun-2016