WERAM Information

Tag Content
WERAM ID WERAM-Mum-0165
Ensembl Protein ID ENSMUSP00000026665.7
Uniprot Accession O55187; CBX4_MOUSE; Q149G5; Q149G6
Genbank Protein ID NP_031651.2
Protein Name E3 SUMO-protein ligase CBX4
Genbank Nucleotide ID NM_007625.2
Gene Name CBX4;Pc2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000039989.7 ENSMUST00000026665.7 ENSMUSP00000026665.7
Details
Type Family Domain Substrates AA References (PMIDs)
Me_Reader Chromodomain Chromo H3K9me3 K 22872859
Status Reviewed
Classification
Type Family E-value Score Start End
Me_Reader Chromodomain 6.40e-23 82.1 11 68
Organism Mus musculus
NCBI Taxa ID 10090
Functional Description
(View)		 E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression.
Domain Profile
  Me_Reader Chromodomain
      Chromodomain.txt  1 FeverivdkkelrkgeveYlVrWkGynksddtWepeenLlckelleefekkkekkkkqg 59
                          F+ve+i  kk++rkg+veYlV+W+G++++++tWepeen+l+++ll +f++++++++++g
  ENSMUSP00000026665.7 11 FAVESIE-KKRIRKGRVEYLVKWRGWSPKYNTWEPEENILDPRLLIAFQNRERQEQLMG 68
                          99*****.***********************************************9987 PP
Protein Sequence
(Fasta)		MELPAVGEHV FAVESIEKKR IRKGRVEYLV KWRGWSPKYN TWEPEENILD PRLLIAFQNR 60
ERQEQLMGYR KRGPKPKPLV VQVPTFARRS NVLTGLQDSS ADNRAKLELG TQGKGQGHQY 120
ELNSKKHHQY QPHSKERSGK PPPPGKSGKY YYQLNSKKHH PYQPDPKMYD LQYQGGHKEA 180
PSPTCPDLGT KSHPPDKWAH GAAAKGYLGA VKPLGGGAGA PGKGSEKGPP NGMTPAPKEA 240
VTGNGIGGKM KIVKNKNKNG RIVIVMSKYM ENGMQAVKIK SGEAAEGEAR SPSHKKRAAE 300
ERHPQGDRTF KKAAGASEEK KAEVPCKRRE EEALVSGDAQ PQDLGSRKLS PTKEAFGEQP 360
LQLTTKPDLL AWDPARSSHP PAHHHHHHHH HHHHHTVGLN LSHARKRCLS ETHGEREPCK 420
KRLTARSIST PTCLGGSPVS EHPANVSPTA ASLPQPEVIL LDSDLDEPID LRCVKMRSDA 480
GEPPSTLQVK PEAPAVAAVV APAPASEKPP AEAQEEPVEP LSEFKPFFGN IIITDVTANC 540
LTVTFKEYVT V 551
Nucleotide Sequence
(Fasta)		GAGCGAGCGA GCGCGAGCTG AGAGCCGGCG GGTGCAGGCA GCGGCGGCGG CGGCGGCGGC 60
CAGGCTGTTG AGGGGCGAGT GGCGGCGGCG GGGGCCGGGC GCGTGGCGAG GTCCACGCGC 120
AGGATCGTAT CGGGGCGCCG GCGGGAGCTA GCTGTGTCTG CAGCCGCGCC GGCCGCTTGC 180
GCCCCTGAGC GCTCGGGTTC GGCCATGGAG CTGCCAGCTG TTGGCGAGCA CGTCTTCGCG 240
GTGGAGAGCA TCGAAAAGAA GCGGATACGC AAGGGCAGAG TGGAGTATCT GGTGAAATGG 300
AGAGGCTGGT CCCCCAAATA TAACACGTGG GAACCAGAGG AGAACATCTT GGATCCCCGG 360
CTGCTGATCG CCTTCCAGAA CAGGGAAAGG CAGGAGCAGC TGATGGGATA TCGCAAGAGA 420
GGGCCCAAGC CCAAACCGCT GGTGGTGCAG GTGCCCACCT TTGCCCGACG CTCCAATGTT 480
CTGACTGGGC TTCAAGACTC CTCCGCTGAC AACCGTGCCA AGCTGGAGTT GGGCACACAG 540
GGCAAGGGCC AGGGGCACCA GTATGAGCTC AACAGCAAGA AGCACCATCA GTACCAGCCA 600
CATAGCAAGG AGAGGTCCGG TAAGCCGCCC CCGCCAGGGA AGAGCGGCAA GTATTATTAT 660
CAGCTAAATA GCAAAAAGCA CCACCCCTAC CAGCCAGACC CCAAAATGTA CGACCTGCAG 720
TACCAGGGCG GCCACAAGGA GGCACCCAGC CCCACCTGCC CAGACCTGGG CACCAAGAGC 780
CACCCTCCTG ACAAGTGGGC CCACGGAGCT GCAGCCAAAG GCTACCTCGG GGCCGTGAAG 840
CCCTTGGGGG GAGGGGCAGG AGCTCCAGGC AAGGGCTCGG AAAAGGGCCC CCCCAATGGC 900
ATGACACCAG CCCCTAAGGA GGCAGTGACC GGTAATGGTA TTGGGGGCAA GATGAAAATC 960
GTCAAGAACA AGAACAAGAA TGGGCGCATC GTGATCGTTA TGAGCAAGTA CATGGAGAAC 1020
GGCATGCAGG CAGTGAAAAT CAAGTCGGGC GAGGCCGCCG AGGGCGAGGC GCGCTCCCCC 1080
AGCCACAAGA AACGTGCTGC CGAGGAGCGC CATCCCCAGG GCGACAGGAC TTTTAAAAAG 1140
GCAGCCGGTG CCTCTGAGGA GAAGAAAGCC GAAGTGCCCT GCAAACGCAG GGAGGAGGAG 1200
GCTCTGGTGT CGGGGGACGC GCAGCCCCAG GACCTAGGGT CTCGAAAGCT CTCCCCGACC 1260
AAGGAGGCCT TTGGTGAGCA ACCGCTACAG CTCACCACCA AGCCAGACCT GCTGGCCTGG 1320
GACCCAGCCA GGAGCTCGCA CCCGCCCGCC CACCACCACC ATCACCACCA CCATCACCAC 1380
CACCACCATA CGGTGGGCCT GAACCTCTCC CATGCGCGCA AGCGCTGCCT CTCCGAGACC 1440
CATGGGGAGC GTGAGCCCTG TAAGAAGCGG TTGACCGCCC GCAGCATCAG CACGCCGACC 1500
TGCCTGGGGG GCAGCCCGGT CTCCGAGCAC CCTGCCAACG TATCCCCCAC CGCGGCCTCT 1560
CTGCCGCAGC CCGAGGTCAT CCTTTTAGAC TCAGACCTGG ATGAACCCAT AGACTTGCGC 1620
TGTGTCAAGA TGCGCAGCGA CGCCGGGGAA CCGCCCAGCA CCCTCCAGGT GAAGCCCGAG 1680
GCTCCAGCTG TGGCGGCAGT GGTGGCGCCG GCCCCTGCCT CAGAGAAGCC TCCCGCTGAG 1740
GCCCAGGAGG AGCCAGTGGA GCCCTTGAGT GAGTTCAAGC CCTTCTTTGG GAATATAATT 1800
ATCACTGACG TCACGGCGAA CTGCCTTACC GTCACTTTCA AGGAATACGT GACGGTGTAG 1860
TGGGAAGGAG TCGCGCCCAC TAGGACTCAG CACCTACAGA GGTTCCCAAG GAGAAAACGC 1920
CCCAGTCGCG GTGGCCAGGC CCTTGCTCAC TCCCTGGGAT CCCGATTGAG TTGTCCACCT 1980
CTCACTGTCT CCTTCCACGT GGTGCCTGCG GTCTCACCGC CACGTCCCCT TCCCTATAGG 2040
AGACCTGAGC CTTCCCTGTG GACCACCAGA ACTGACCCGC AGCCCCGAGG CAGTCTCAGA 2100
GCTATAGTAT TATATTTTAA CCGTGCTAAC TGTCAAGTGC TGACTCTACT CCGGTTTGTA 2160
CGTGGTGTTA TTCTTGAAAT GTATTGTTTG AGCTCAGAAG GCCCGACTAT CCCCCTTAGG 2220
GCTGATATAT ATACATATAT ATATATTTAT TTGTAGGTAT TTATATATTG AAATATAAAA 2280
ACCTAGATTT ATGGAGTTTC CTCTAGATCA TGTTATATTC TATATCAGAC AGACTATTTT 2340
AAGTTGGCCT TTTCTTTCCC CTTCATTCAG TATTTTGATT TTATTTCCCC TTCTCCAGGA 2400
ACTGCGACAC CAGTAACCTT GGTATATATT TTTTGATACT GTACACATGG GTGTGTTGTT 2460
TCTATGTGCA AAAAAAAAAG TTTGTTAAAA GGCTAAAGAG CTCTCTAGAA CCTGCTGCTA 2520
TAGAAATGTC TGAACTATAA GCTTCCAATT ATTACCTGCT TGAATGTAAA TATTAAATGG 2580
AGATGTTGAA GGTGCAATTC AGTGTCCGAG ATTAGCTCCA GGGGGATGTC GGAAGGTCCG 2640
AAGTTGAGGG AAAGAGGACG GACCCTCTCT CACCCCACCA AGGTCACGTG GAAAAAGACT 2700
CTCTAAAGCT AAGTCTTTGC ACAAGCCAAG CCTGTGGGGT CTGGTGTCTC TAGAGCAGCT 2760
CCTTCATTGG AAGGTGACTC AGTGTGGGAA AATCGAGAGG TGCTAGCCTG GAAGAGTGGA 2820
GTGGGGGGAA TGTATCAGAG TCGCCCTAGT CCCTGGGGCT TTCTGGCTGG CGATGCTCAC 2880
GTAGCTGGCA AACCAGTAAT TTCTGGGTTG TAGAGGGGCG AGAAATGGGG GCACTGCACC 2940
CCCACTTCCT GGATCCTGAC TCTTAGGCTG GTGGCCCTTG CCCCGCCCCT CAAGCCAAGC 3000
CCTCAGCCCT CCCTGCTGTG GGCCAGGATA CAAGTGGAGT AGACCCCAAC TCTTTGGGGC 3060
TGTCCCGGGC TCAAAGGAAG CAGAGGAAAC CCTTTCTCTG CCAGGCTCTC TCCCCGGAAA 3120
CTACCAGGCC AAAGGCCAGG GCTGGAGCAA GTGAACTGCT GTGTTGGGCC TTCTACTGGA 3180
TGATTTGGGA GGGGGCGACA GGGCGCTGAG TCTGGCCTGC CACCCTCTCT TCCTTAGCTG 3240
CGTGGGCTGG CACTGGTTGC CCATCCCCTT GGTGGCTACT AGGAGGTGCT AGGTGTGTCT 3300
GGAGAAGGGA AGAAAGGGGT TAATGGCCCC TAGGCTAGGG GTGCGGCTCG GCCAGGCCAG 3360
GAAGCCACCA CCAGCGGCCA GCTTTCTGCA GACACAGCGA TCTTCCTCCT GGTTCAGTGG 3420
CTAAACAGGC CCTGGGGCCT CCGGCCTGGG GAATCTGGTG AGCTTCAGGA TTCTCCCTGC 3480
TGGCAAAGCC TCAGTTCGGG ACCGAGGGTC GAGCCTATAG TGACACCAGG GCAGAAGATG 3540
ACAGCGTGGT TTGGAGTGTG TGTTTGTGTG TGTGTGGCAG GGGGTGCTGA GGTAGTTCGA 3600
GGGGCAGAGT TGGGAAGGCT GGGGAAGAGA TGGAGAGGAA GGCCTAGAGG GCGGGAGGCT 3660
CGATGCACGG AGTGGCCAGT TTTGGCTGCA GGCCATCAGC GGCTGTGGCT GGGGGAGGGG 3720
CGCGGGGCGG GGGAGGGGAG GAGGGAAGGG AACCGCTTTT TTGAAAAAGC CTTTGGGAGT 3780
TTGTAGCCCC GGCTTTTGTG AATCGTCCCT CCCACTACCC CATCCCCGGG AGCCCCCTTC 3840
AGAGTGAGTT AAACACCCCT CCCCCTCTGT GTAATGAACG CCCTTTGCCA CCCTGTGAGT 3900
GGAGGAGGCT GATCTTGCTT CTGGCAACCG GCCTGCTCGG CGCTAGAATT GGGCCTGTCC 3960
TTCACTGGCT GGTGCACAAA GGCCCGTGCC AGGCAGGAAC CTCAGCCCCT GCTTTTCCAG 4020
TTCATGAGAA CTGAAAACTC CCGAATGCTG CTGATCAGAC CTAGAGGTGG AGCCTTGGCA 4080
GTAGGTCTGG CCCCTGAGGT GGCCCCTTTT CTGCCAAGCT TGGGGAGAGA ACCGAAGAGG 4140
CGGAAGATGG CTCTCCTGGA TGGCTACTAG TTCACTAGTC TTCCTGGAAA AGCCTGGTCT 4200
ACAGGTGCCA TGACTCCTTG AAAGCTGGGT ATGGGTGCAG GGCCTGTGGA GTGAGGTGCC 4260
CCAGTCAGAG GGTAAATAGA GGGCCGAGAT CTAAGGGAGC AGATAAGGCG TCCAGCCTGG 4320
TTGTCAAGAC CCCCCATCTG TCCCCAAGGG GACAAGGGCT TGTCATTTAC TGTGTTCCTT 4380
TGATGTCCCA TGAGCATTGT GGCTTATTTA GTCCCCAAGT AGGCCAGCTC TCTGTGACAC 4440
AGGTCTGAGG TTCTGATGGG CATTCCCTAG TTCTTGTCTT GATTCTGGAA CCAAACTGGC 4500
TGGTCCCAAT CCTGCAGAGG CTCCCCAGGA CTCTGCCCTC TCAGGCCTCG GTGCTGGCCT 4560
CAGAGGACAA GTAGGACAAG GATAGAAACA GACTTCCTCC TTCAAGGGGC ACTTGGGCAG 4620
AAAGGGTTCA GAAGGCCCAG CTCTCCTGGT GTGGGTGGTC TCTGACCAGC ACTTTATAAA 4680
CAGCTGGTCA CGAACTCTCT CTTTGAAGAC GAGAGTTCAG ATTCAAGAGT GAAAAGGAAG 4740
GCTTTGCATT CTACACATAC CCACACCATC CAAATGGCTT TTCCCCCCAT CAGAATGAAC 4800
CCAAACCGTT CTTACATGCT TAAGCCTCAG GCACAGAGGC CAGAGCTAGG AGTTCAAAGG 4860
CCCTGGGGGT ATTTGTGAAG CCTCCTGCCC AGAGCTGGCT TGACTACAGC TCTGGTCGAC 4920
CAGTAGTCTG CCCTGACTGT CTCAGCTTAG TTCCAGAAGA TCCAAGTTTA TCCCACAGTC 4980
TTTACTCCAT CCTTGGACAC CACAGTTGGT GTCATTTGTT GGAGATGTCC CACAGATGCA 5040
GCATGGTGTG GGTCTAGAGT TGTCAGGCCA AACAAATAAG AATTTAGGGT TCTTAGCTCA 5100
ATTTGGATAG CGTATGCATA TAAATCAATC ACTAGCATAT GCATGTAAAT GCTTATAAAT 5160
AAATAAATAT TTAAAGGTT
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0436--Ligase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
--
Interpro

IPR000953--Chromo/shadow_dom
IPR017984--Chromo_dom_subgr
IPR023780--Chromo_domain
IPR016197--Chromodomain-like
IPR023779--Chromodomain_CS
PROSITE

PS00598--CHROMO_1
PS50013--CHROMO_2
Pfam

PF00385--Chromo
Gene Ontology

GO:0016604--C:nuclear body
GO:0016607--C:nuclear speck
GO:0005634--C:nucleus
GO:0031519--C:PcG protein complex
GO:0035102--C:PRC1 complex
GO:0003682--F:chromatin binding
GO:0019899--F:enzyme binding
GO:0016874--F:ligase activity
GO:0035064--F:methylated histone binding
GO:0051219--F:phosphoprotein binding
GO:0003727--F:single-stranded RNA binding
GO:0032183--F:SUMO binding
GO:0019789--F:SUMO transferase activity
GO:0044212--F:transcription regulatory region DNA binding
GO:0016568--P:chromatin modification
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0016925--P:protein sumoylation
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Otg-0228 ENSOGAP00000015725.1 Otolemur garnettii 89 0.0 830
WERAM-Sus-0127 ENSSSCP00000018183.2 Sus scrofa 88 0.0 827
WERAM-Ict-0199 ENSSTOP00000021274.1 Ictidomys tridecemlineatus 89 0.0 822
WERAM-Chs-0027 ENSCSAP00000015691.1 Chlorocebus sabaeus 88 0.0 813
WERAM-Paa-0138 ENSPANP00000016273.1 Papio anubis 88 0.0 811
WERAM-Pat-0211 ENSPTRP00000060551.1 Pan troglodytes 87 0.0 807
WERAM-Hos-0137 ENSP00000269397.4 Homo sapiens 87 0.0 807
WERAM-Gog-0105 ENSGGOP00000009074.2 Gorilla gorilla 81 0.0 744
WERAM-Bot-0095 ENSBTAP00000040225.3 Bos taurus 73 3e-166 582
WERAM-Lac-0174 ENSLACP00000020449.1 Latimeria chalumnae 49 1e-121 434
WERAM-Ran-0197 ENSRNOP00000066624.1 Rattus norvegicus 99 6e-111 398
WERAM-Xet-0083 ENSXETP00000028020.2 Xenopus tropicalis 56 1e-94 344
WERAM-Orla-0019 ENSORLP00000002324.1 Oryzias latipes 44 4e-91 332
WERAM-Asm-0047 ENSAMXP00000006389.1 Astyanax mexicanus 43 3e-88 323
WERAM-Orn-0039 ENSONIP00000004213.1 Oreochromis niloticus 42 1e-85 314
WERAM-Gam-0115 ENSGMOP00000012079.1 Gadus morhua 40 2e-85 313
WERAM-Gaa-0195 ENSGACP00000024086.1 Gasterosteus aculeatus 40 8e-85 311
WERAM-Pof-0200 ENSPFOP00000016491.2 Poecilia formosa 40 9e-84 308
WERAM-Xim-0219 ENSXMAP00000017952.1 Xiphophorus maculatus 41 1e-82 304
WERAM-Ten-0209 ENSTNIP00000021158.1 Tetraodon nigroviridis 39 1e-75 281
WERAM-Tar-0020 ENSTRUP00000004308.1 Takifugu rubripes 38 2e-74 277
WERAM-Dar-0204 ENSDARP00000132706.1 Danio rerio 56 5e-69 259
WERAM-Leo-0140 ENSLOCP00000017081.1 Lepisosteus oculatus 72 1e-66 251
WERAM-Anc-0080 ENSACAP00000007637.2 Anolis carolinensis 71 1e-30 131
WERAM-Pes-0116 ENSPSIP00000013945.1 Pelodiscus sinensis 70 2e-30 131
WERAM-Aim-0120 ENSAMEP00000011388.1 Ailuropoda melanoleuca 70 2e-30 130
WERAM-Dan-0191 ENSDNOP00000026605.1 Dasypus novemcinctus 70 3e-30 130
WERAM-Fec-0174 ENSFCAP00000024437.1 Felis catus 70 3e-30 130
WERAM-Dio-0093 ENSDORP00000009462.1 Dipodomys ordii 70 3e-30 130
WERAM-Mup-0151 ENSMPUP00000013148.1 Mustela putorius furo 70 3e-30 130
WERAM-Tut-0014 ENSTTRP00000001188.1 Tursiops truncatus 70 4e-30 130
WERAM-Caf-0017 ENSCAFP00000001948.3 Canis familiaris 70 5e-30 130
WERAM-Mam-0061 ENSMMUP00000010301.2 Macaca mulatta 70 5e-30 129
WERAM-Ova-0175 ENSOARP00000017609.1 Ovis aries 70 1e-29 129
WERAM-Gaga-0164 ENSGALP00000037077.2 Gallus gallus 68 8e-29 125
WERAM-Loa-0080 ENSLAFP00000006257.4 Loxodonta africana 52 1e-28 125
WERAM-Poa-0210 ENSPPYP00000024136.1 Pongo abelii 52 1e-28 125
WERAM-Ect-0084 ENSETEP00000009565.1 Echinops telfairi 52 1e-28 125
WERAM-Cap-0201 ENSCPOP00000016560.1 Cavia porcellus 52 1e-28 125
WERAM-Caj-0191 ENSCJAP00000032804.1 Callithrix jacchus 52 1e-28 125
WERAM-Eqc-0159 ENSECAP00000016784.1 Equus caballus 52 1e-28 125
WERAM-Tub-0039 ENSTBEP00000004995.1 Tupaia belangeri 68 2e-28 125
WERAM-Nol-0003 ENSNLEP00000000196.1 Nomascus leucogenys 51 2e-28 124
WERAM-Myl-0216 ENSMLUP00000018435.1 Myotis lucifugus 68 3e-28 124
WERAM-Prc-0153 ENSPCAP00000014543.1 Procavia capensis 68 3e-28 124
WERAM-Mod-0074 ENSMODP00000011965.2 Monodelphis domestica 67 5e-28 123
WERAM-Sah-0110 ENSSHAP00000011795.1 Sarcophilus harrisii 57 6e-28 123
WERAM-Ptv-0108 ENSPVAP00000009576.2 Pteropus vampyrus 55 1e-26 118
WERAM-Tag-0129 ENSTGUP00000010594.1 Taeniopygia guttata 67 1e-23 108
WERAM-Ere-0050 ENSEEUP00000004312.1 Erinaceus europaeus 69 1e-22 105
WERAM-Ora-0048 ENSOANP00000007669.2 Ornithorhynchus anatinus 66 2e-18 91.3
WERAM-Zem-0068 GRMZM2G117100_P01 Zea mays 45 3e-12 70.9
WERAM-Sei-0132 Si036395m Setaria italica 50 5e-10 63.5
WERAM-Vip-0106 ENSVPAP00000009695.1 Vicugna pacos 46 1e-08 58.9
WERAM-Orc-0018 ENSOCUP00000002132.2 Oryctolagus cuniculus 46 1e-08 58.9
WERAM-Chh-0115 ENSCHOP00000012258.1 Choloepus hoffmanni 46 1e-08 58.9
WERAM-Mim-0066 ENSMICP00000006372.1 Microcebus murinus 46 1e-08 58.9
WERAM-Soa-0076 ENSSARP00000007237.1 Sorex araneus 46 1e-08 58.9
Created Date 25-Jun-2016