WERAM Information

Tag Content
WERAM ID WERAM-Art-0071
Ensembl Protein ID AT3G14980.1
Uniprot Accession F4IXE7; IDM1_ARATH; Q9LKA7
Genbank Protein ID NP_188116.1
Protein Name Increased DNA methylation 1
Genbank Nucleotide ID NM_112360.2
Gene Name IDM1;ROS4;At3g14980;K15M2.12
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
AT3G14980 AT3G14980.1 AT3G14980.1
Details
Type Family Domain Substrates AA References (PMIDs)
HAT GNAT_other N-acetyltransferase H3K18; H3K23 K 22700931; 24920332
Status Reviewed
Classification
Type Family E-value Score Start End
Me_Reader PHD 6.40e-09 36.7 727 819
Organism Arabidopsis thaliana
NCBI Taxa ID 3702
Functional Description
(View)		 Histone H3 acetyltransferase that binds methylated DNA at chromatin sites lacking histone H3K4 di- or trimethylation and catalyzes H3K18 and H3K23 acetylation (PubMed:22733760, PubMed:22700931). Prevents the transcriptional silencing of transgenes and of some endogenous genes (PubMed:22733760, PubMed:22700931). Requires the presence of IDM2 for efficient H3K18 acetylation, but not for H3K23 acetylation (PubMed:25002145).
Domain Profile
  Me_Reader PHD
      PHD.txt   2 tiClvCgkddegekemvqCdeCddwfHlkCvklplsslpegkswyCpsCk 51 
                  ++C vC   d ge  +++Cd+C+  fH+ C++++   lpeg swyC sC+
  AT3G14980.1 727 DSCGVC--GDGGE--LICCDNCPSTFHQACLSMQ--VLPEG-SWYCSSCT 769
                  57****..33332..9******************..*****.*******7 PP
      PHD.txt   4 ClvCg...kddegekemvqCdeCddwfHlkCvklplsslp.egkswyCps 49 
                  C +C+    d++++++ ++C++C + +H++C++   ++ +  ++ ++C +
  AT3G14980.1 770 CWICSelvSDNAERSQDFKCSQCAHKYHGTCLQGISKRRKlFPETYFCGK 819
                  999954443333344499**************987333332225799964 PP
Protein Sequence
(Fasta)		MLPGAEIEML GGDCFEGSYE DHQIFREVFF GSDPGNTTKR CLVTGAINFE CDSSKNVNSS 60
LSSNSVVTSG YACPQGFEAS ASRDGSDFNT KAKRVKLSGN KHLDARDEKG SALHGFPTSD 120
IARETIPLHL VESSNKGVST SSYLLKHSIV KGREVYLGGI VSGKCKSLNL DKCDGKEFKA 180
IASPVSQESF ATRMISVGAS TPHSEKACFP LQLNNGSKVS PNELIMSKTC LKIDPKEDPR 240
PLLYKYVCKV LTAARWKIEK RERSAGRKHV DTFYISPEGR KFREFGSAWK ALGGILLADR 300
KLMDTGTKKW TGINDFWSDL SLTLLDIEEN MKNLNLANTR ALWWSALEPF VVVVFISKQV 360
GSLRKGNKVE VARNSNPDKL KKEDTICLNL ISGCPESVLT VSEGSHLVHD VDANQEIHSD 420
LEVQTKISSQ KVSSRLERQS IIGKEISGTH EQEASKGIVA SKLIAEDMHE SVMRKNLHRR 480
SKKISDIKPA SLDQHDSLDS NSLNSFEFQD KEMGNIHLVS KGSRDERLRN EKMNNSCCNS 540
KKGRKKARKH YTQDDDLMGS TITRNKGKFS RSSQKKKTQK PKARTKKRNN RGGCRLLPRS 600
SSNVENHFFQ GNWSILGPRT VLSWLIATKV ISRDEVIQLR DPDDDTVVKT GLVTKDGVVC 660
TCCNKTVSLS EFKNHAGFNQ NCPCLNLFMG SGKPFASCQL EAWSAEYKAR RNGWRLEKAS 720
DDDPNDDSCG VCGDGGELIC CDNCPSTFHQ ACLSMQVLPE GSWYCSSCTC WICSELVSDN 780
AERSQDFKCS QCAHKYHGTC LQGISKRRKL FPETYFCGKN CEKVYNGLSS RVGIINPNAD 840
GLSWSILKCF QEDGMVHSAR RLALKAECNS KLAVALSIME ESFLSMVDPR TGIDMIPHVL 900
YNWGSTFARL DFDGFYTVVV EKDDVMISVA SIRVHGVTIA EMPLVATCSK YRRQGMCRIL 960
VAAIEEMLMS LKVEKLVVAA LPSLVETWTE GFGFKPMDDE ERDALKRINL MVFPGTTLLK 1020
KTLYESTKPS TMKGVCLSKE RNNPSNKEAD LEPGLDKAGS PMSTQVESCD QMVPAGSDDE 1080
PSPGFPVPLG ADQTEPTSET ENPSRDSNAN DRPNKTTVVS IGEEEEEECL QKDVSKLSEE 1140
GKETTRASSS SAALEEVSGL GLGVVNNVSD EMLLCVDEQL DSDSSQDSE 1189
Nucleotide Sequence
(Fasta)		ATCTATCTGA TGAATTTTGG TTGAGAGATT TAACACCGAA TCAGAGGTGG GTTTCTTCCA 60
CAATTATAGA AAAAGCTAAA AAGATAGACA AATTGTTGTT CTTTCTGTGT GTGAGATAGA 120
GATCAAGGAG AGAGAGTGTG TGAGTGCAGA GAACGTGAAA TGGAATGAAA ATGCGTTTCC 180
CACTTGCGGT TGGAGAGGAT AAGGGCGACG AAATGAGTCT ATTTCAGTGA GAAGAAGCCA 240
TTTCTCCGAT TTCACAGCTC TGATTTCATT CTGCATGCTG GTATCTATCT ACAACCTTCC 300
TTTTAAGTTA AGGTGAAGTG GAATATGCAG TTAGTTTGTG GAGATGCTTC CCGGAGCTGA 360
GATTGAGATG TTAGGAGGTG ACTGCTTTGA AGGGTCATAT GAGGATCATC AGATATTCAG 420
AGAAGTTTTC TTTGGAAGTG ATCCTGGAAA TACTACTAAA AGATGTCTCG TTACTGGAGC 480
CATTAACTTC GAATGTGATT CCAGTAAGAA TGTCAATTCC TCTCTGAGTT CCAACTCTGT 540
GGTAACTAGT GGATATGCAT GTCCACAAGG TTTTGAGGCA TCTGCTTCAA GAGATGGTTC 600
AGATTTTAAC ACTAAAGCTA AGAGAGTGAA GCTTTCAGGT AATAAGCATT TGGATGCAAG 660
GGACGAAAAG GGATCTGCTT TGCATGGTTT TCCAACTTCG GACATAGCTA GAGAGACGAT 720
ACCTCTCCAT TTAGTTGAAT CATCTAACAA GGGTGTTTCA ACTAGCTCAT ATTTGTTGAA 780
GCACAGCATA GTAAAGGGAA GAGAAGTTTA TCTGGGTGGC ATTGTGTCTG GAAAGTGTAA 840
GTCACTAAAC TTGGACAAAT GCGATGGAAA GGAATTTAAA GCTATTGCCT CTCCTGTTTC 900
TCAGGAGAGC TTCGCAACCA GAATGATCTC TGTAGGTGCT TCTACGCCGC ATAGTGAGAA 960
GGCTTGCTTC CCGCTACAGT TGAACAACGG ATCTAAAGTA TCTCCTAATG AGTTAATTAT 1020
GTCTAAAACC TGCCTAAAGA TTGATCCTAA AGAGGACCCC CGTCCTCTTC TCTACAAGTA 1080
TGTCTGTAAG GTTCTAACTG CTGCCAGATG GAAAATTGAG AAGCGCGAAA GATCAGCAGG 1140
TAGGAAACAT GTAGACACAT TTTACATATC GCCAGAGGGA CGGAAATTTC GTGAATTTGG 1200
GTCAGCTTGG AAAGCATTGG GTGGGATCCT ATTAGCTGAT CGTAAGTTAA TGGATACTGG 1260
TACTAAGAAA TGGACTGGTA TTAATGACTT CTGGTCCGAT CTCTCTCTTA CACTGTTGGA 1320
CATCGAGGAG AACATGAAAA ATTTAAATCT TGCTAACACA CGGGCACTTT GGTGGAGTGC 1380
CTTAGAGCCT TTTGTGGTTG TTGTCTTCAT TTCTAAGCAA GTTGGTTCTT TAAGAAAAGG 1440
AAATAAAGTT GAAGTTGCAA GGAATTCAAA TCCAGACAAG TTGAAGAAAG AAGATACAAT 1500
TTGTTTGAAC CTGATTTCAG GCTGTCCTGA AAGTGTGCTG ACAGTATCTG AAGGCAGTCA 1560
TCTTGTTCAT GACGTGGATG CTAACCAAGA GATACATTCA GATCTTGAGG TGCAAACTAA 1620
AATTTCCTCT CAAAAAGTTT CTTCAAGACT AGAGAGGCAG AGCATAATTG GTAAGGAAAT 1680
CTCTGGGACT CATGAGCAGG AGGCTAGCAA GGGCATTGTA GCTTCAAAAT TGATAGCAGA 1740
AGACATGCAT GAAAGTGTTA TGAGAAAGAA CTTACACAGA AGATCAAAGA AAATATCCGA 1800
TATCAAACCA GCTTCCTTGG ACCAACATGA TTCACTAGAT TCTAATTCTC TCAATAGCTT 1860
TGAATTCCAG GATAAAGAGA TGGGCAACAT TCACCTCGTC TCAAAGGGAA GTCGGGATGA 1920
AAGGTTGAGG AATGAGAAGA TGAATAATTC ATGTTGCAAT TCAAAGAAAG GAAGAAAGAA 1980
AGCTAGGAAG CACTATACTC AAGATGATGA CCTTATGGGG TCGACAATAA CCAGAAACAA 2040
AGGTAAGTTC AGCAGATCAA GCCAGAAAAA GAAAACACAG AAGCCAAAGG CTAGAACAAA 2100
GAAAAGAAAC AATAGGGGAG GGTGCAGGTT GCTTCCCCGA AGCTCAAGCA ATGTGGAAAA 2160
TCATTTTTTT CAAGGAAATT GGTCTATTTT GGGTCCTAGA ACTGTCTTAT CATGGTTGAT 2220
AGCTACCAAA GTAATTTCTA GAGACGAAGT AATCCAGTTA CGAGATCCAG ATGATGATAC 2280
TGTGGTAAAA ACAGGCCTGG TAACTAAAGA TGGAGTGGTT TGTACATGTT GCAACAAGAC 2340
TGTGTCACTT TCTGAATTCA AGAACCATGC TGGATTTAAC CAGAACTGTC CATGTCTGAA 2400
TCTTTTCATG GGGTCAGGAA AGCCTTTCGC TTCATGTCAG CTGGAAGCTT GGTCTGCTGA 2460
GTATAAGGCG CGAAGAAATG GATGGAGATT AGAGAAAGCC TCTGATGATG ATCCAAATGA 2520
TGATTCTTGT GGAGTTTGTG GTGATGGGGG TGAGCTGATC TGCTGTGATA ATTGTCCATC 2580
TACCTTCCAT CAGGCGTGCT TATCAATGCA GGTGCTCCCT GAAGGAAGTT GGTATTGCTC 2640
GAGCTGCACA TGTTGGATAT GCAGCGAGTT GGTTAGTGAT AATGCTGAAC GCTCTCAGGA 2700
CTTTAAATGT TCCCAGTGTG CGCATAAATA TCATGGAACA TGTTTGCAAG GGATAAGTAA 2760
ACGCAGAAAG CTTTTTCCAG AGACCTACTT TTGTGGTAAA AATTGCGAGA AGGTGTACAA 2820
TGGTCTTAGT TCTCGTGTTG GGATCATTAA CCCTAATGCT GATGGTCTGT CTTGGTCAAT 2880
TCTTAAATGT TTTCAAGAAG ATGGAATGGT TCATTCTGCC CGAAGGTTGG CGCTGAAGGC 2940
TGAATGCAAC TCGAAATTAG CTGTTGCCCT ATCAATTATG GAGGAAAGCT TTCTGTCTAT 3000
GGTAGATCCA AGAACTGGTA TTGACATGAT ACCTCATGTG CTATACAACT GGGGGTCAAC 3060
ATTTGCTCGG TTAGACTTTG ATGGGTTTTA CACAGTGGTT GTGGAAAAGG ATGATGTGAT 3120
GATCTCAGTA GCATCTATCA GGGTGCACGG AGTAACTATT GCAGAGATGC CTCTTGTAGC 3180
TACGTGCAGC AAATATCGCC GACAGGGCAT GTGTAGAATC CTCGTGGCTG CCATTGAAGA 3240
GATGCTTATG TCTCTCAAAG TGGAGAAGCT TGTGGTAGCT GCATTGCCGA GTTTAGTGGA 3300
AACTTGGACT GAAGGTTTTG GCTTCAAACC CATGGATGAT GAAGAGCGTG ATGCTCTCAA 3360
AAGAATAAAC TTGATGGTAT TCCCTGGGAC AACTCTGCTC AAGAAAACAC TATACGAGAG 3420
CACAAAACCC AGCACTATGA AAGGTGTATG TCTTTCTAAA GAACGCAATA ACCCATCAAA 3480
CAAAGAAGCA GATCTAGAGC CAGGTCTAGA CAAAGCCGGG TCTCCCATGA GTACCCAAGT 3540
TGAGAGCTGT GATCAGATGG TTCCAGCAGG TTCAGATGAT GAGCCATCCC CAGGCTTCCC 3600
CGTACCACTC GGAGCCGATC AAACAGAACC AACTTCAGAA ACAGAGAACC CAAGCCGAGA 3660
CAGCAATGCC AATGATAGGC CAAATAAAAC AACAGTAGTC TCTATAGGAG AAGAAGAAGA 3720
AGAAGAATGT TTGCAGAAAG ATGTATCAAA GTTATCAGAA GAAGGAAAAG AAACGACAAG 3780
GGCTTCTTCT TCCTCTGCAG CTTTAGAAGA AGTTAGTGGT CTAGGACTAG GAGTAGTAAA 3840
TAATGTTAGC GATGAGATGT TGCTTTGTGT TGATGAACAG CTTGACTCTG ATAGCTCTCA 3900
GGATTCGGAA TAA 3914
Sequence Source Ensembl
Keyword

KW-0012--Acyltransferase
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger
--
Interpro

IPR016181--Acyl_CoA_acyltransferase
IPR000182--GNAT_dom
IPR032308--Jas
IPR001739--Methyl_CpG_DNA-bd
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51186--GNAT
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF16135--Jas
PF00628--PHD
Gene Ontology

GO:0005634--C:nucleus
GO:0009506--C:plasmodesma
GO:0010385--F:double-stranded methylated DNA binding
GO:0004402--F:histone acetyltransferase activity
GO:0042393--F:histone binding
GO:0008270--F:zinc ion binding
GO:0044154--P:histone H3-K14 acetylation
GO:0043971--P:histone H3-K18 acetylation
GO:0043972--P:histone H3-K23 acetylation
GO:0044030--P:regulation of DNA methylation
GO:0006355--P:regulation of transcription, DNA-templated
GO:0080188--P:RNA-directed DNA methylation
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Arl-0059 fgenesh2_kg.3__ 1623__ AT3G14980.1 Arabidopsis lyrata 89 0.0 1969
WERAM-Bro-0100 Bo5g127560.1 Brassica oleracea 69 0.0 1503
WERAM-Brr-0136 Bra027290.1-P Brassica rapa 68 0.0 1452
WERAM-Glm-0154 GLYMA12G35760.2 Glycine max 41 0.0 758
WERAM-Sol-0097 Solyc07g062600.2.1 Solanum lycopersicum 40 0.0 719
WERAM-Prp-0010 EMJ14932 Prunus persica 59 0.0 646
WERAM-Thc-0086 EOY13226 Theobroma cacao 62 0.0 635
WERAM-Viv-0120 VIT_19s0014g01500.t01 Vitis vinifera 58 2e-167 587
WERAM-Met-0046 KEH38626 Medicago truncatula 57 2e-164 577
WERAM-Amt-0045 ERN15883 Amborella trichopoda 58 1e-156 551
WERAM-Mua-0094 GSMUA_Achr6P25440_001 Musa acuminata 49 1e-135 482
WERAM-Sob-0094 Sb06g034065.1 Sorghum bicolor 49 1e-134 478
WERAM-Tru-0009 TRIUR3_05331-P1 Triticum urartu 48 5e-134 476
WERAM-Aet-0007 EMT20462 Aegilops tauschii 48 6e-134 476
WERAM-Brd-0130 BRADI5G27517.1 Brachypodium distachyon 48 2e-133 474
WERAM-Sei-0077 Si020995m Setaria italica 49 5e-133 473
WERAM-Zem-0025 GRMZM2G038050_P01 Zea mays 46 3e-132 470
WERAM-Orbr-0058 OB04G37750.1 Oryza brachyantha 48 1e-131 468
WERAM-Sot-0038 PGSC0003DMT400032367 Solanum tuberosum 52 3e-131 467
WERAM-Tra-0043 Traes_2AL_F68D162A8.2 Triticum aestivum 48 2e-130 464
WERAM-Hov-0086 MLOC_65889.1 Hordeum vulgare 46 9e-128 456
WERAM-Orb-0048 OBART04G30730.1 Oryza barthii 48 4e-126 450
WERAM-Orni-0045 ONIVA04G29920.1 Oryza nivara 47 5e-126 450
WERAM-Orr-0048 ORUFI04G32440.1 Oryza rufipogon 47 5e-126 450
WERAM-Orgl-0047 OGLUM04G30610.1 Oryza glumaepatula 47 6e-126 449
WERAM-Orl-0058 KN539151.1_FGP008 Oryza longistaminata 52 5e-117 420
WERAM-Ors-0046 OS04T0691700-01 Oryza sativa 56 8e-100 363
WERAM-Org-0048 ORGLA04G0270900.1 Oryza glaberrima 56 1e-99 362
WERAM-Sem-0001 EFJ24916 Selaginella moellendorffii 45 2e-99 361
WERAM-Lep-0071 LPERR07G04130.1 Leersia perrieri 40 2e-96 351
WERAM-Ori-0046 BGIOSGA014033-PA Oryza indica 55 3e-96 351
WERAM-Orm-0068 OMERI07G03260.1 Oryza meridionalis 41 1e-95 349
WERAM-Orp-0069 OPUNC07G04530.3 Oryza punctata 40 2e-95 348
WERAM-Php-0118 PP1S59_348V6.1 Physcomitrella patens 36 7e-89 326
WERAM-Pot-0028 POPTR_0002s11940.1 Populus trichocarpa 35 1e-68 259
WERAM-Myl-0123 ENSMLUP00000009992.2 Myotis lucifugus 65 1e-12 73.6
WERAM-Eqc-0088 ENSECAP00000010777.1 Equus caballus 63 3e-12 72.0
WERAM-Pat-0115 ENSPTRP00000024049.4 Pan troglodytes 54 5e-12 71.6
WERAM-Caj-0141 ENSCJAP00000025299.2 Callithrix jacchus 56 5e-12 71.6
WERAM-Gog-0061 ENSGGOP00000005561.2 Gorilla gorilla 63 8e-12 70.9
WERAM-Chs-0092 ENSCSAP00000004087.1 Chlorocebus sabaeus 63 9e-12 70.9
WERAM-Ptv-0117 ENSPVAP00000010379.1 Pteropus vampyrus 62 9e-12 70.9
WERAM-Aim-0121 ENSAMEP00000011418.1 Ailuropoda melanoleuca 63 9e-12 70.9
WERAM-Hos-0171 ENSP00000291582.5 Homo sapiens 63 9e-12 70.5
WERAM-Sus-0175 ENSSSCP00000026284.1 Sus scrofa 63 1e-11 70.5
WERAM-Gaga-0012 ENSGALP00000040523.2 Gallus gallus 61 1e-11 70.1
WERAM-Orn-0202 ENSONIP00000021047.1 Oreochromis niloticus 42 2e-11 69.7
WERAM-Mam-0031 ENSMMUP00000005576.2 Macaca mulatta 61 2e-11 69.7
WERAM-Caf-0120 ENSCAFP00000015791.3 Canis familiaris 63 2e-11 69.7
WERAM-Fec-0089 ENSFCAP00000007349.3 Felis catus 61 2e-11 69.3
WERAM-Gam-0110 ENSGMOP00000011508.1 Gadus morhua 46 2e-11 69.3
WERAM-Paa-0149 ENSPANP00000012760.1 Papio anubis 61 2e-11 69.3
Created Date 25-Jun-2016