WERAM Information

Tag Content
WERAM ID WERAM-Art-0002
Ensembl Protein ID AT1G02740.1
Uniprot Accession Q4V3E2; MRG2_ARATH; Q9SRX0
Genbank Protein ID NP_171774.2
Protein Name Protein MRG2
Genbank Nucleotide ID NM_100154.3
Gene Name MRG2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
AT1G02740 AT1G02740.1 AT1G02740.1
Details
Type Family Domain Substrates AA References (PMIDs)
Me_Reader Chromodomain Chromo H3K4me3; H3K36me3 K 25855537
Status Reviewed
Classification
Type Family E-value Score Start End
Me_Reader Chromodomain 2.70e-18 66.6 63 118
Organism Arabidopsis thaliana
NCBI Taxa ID 3702
Functional Description
(View)		 Chromatin remodeling factor. Acts as a 'reader' protein by binding to H3K4me3 and H3K36me3 to control histone H4 acetylation. Increases the transcriptional levels of the flowering time genes FLC and FT (PubMed:25183522, PubMed:25211338). Binds the chromatin at the FT promoter upon interaction with CO (PubMed:25211338).
Domain Profile
  Me_Reader Chromodomain
  Chromodomain.txt   3 verivd....kkelrkgeveYlVrWkGynksddtWepeenLlckelleefekkkekkkkqg 59 
                       ++++++    k+e++++e++Y+V+++G+nks+d+W++ ++Ll     +++++++ek+k+qg
       AT1G02740.1  63 SDCFYEakvlKVEFKDNEWKYFVHYIGWNKSWDEWIRLDCLL-----KHSDENIEKQKEQG 118
                       7999999999********************************.....***********998 PP
Protein Sequence
(Fasta)		MGSPNAAAET DLTTDDFIGD TRRDSGSDTE TNTDCDGEDL PLLLLPAPPG HFEEGERVLA 60
KHSDCFYEAK VLKVEFKDNE WKYFVHYIGW NKSWDEWIRL DCLLKHSDEN IEKQKEQGLK 120
QQGIKSAMAW KVSKMKPRSP NVARGRKRKQ DSVDTEKNVL PSDNLLSFNI PPALRKQLLD 180
DFEFVTQMQK LVQLPRSPNV DGILKKYIDS QMKKHGRVTD SLEEILKGLR CYFDKALPVM 240
LLYNNERKQY EESVSGGVSP STVYGAEHLL RLFVKLPELL VHVNMAEETL KELQDNFVDI 300
LRFLRKNQSV LFVSTYKAVE EMEKKEG 327
Nucleotide Sequence
(Fasta)		CTCCTCCTCT TTTTGAGATG GGAAGCCCTA ACGCCGCCGC CGAGACGGAT CTAACAACCG 60
ATGATTTCAT CGGAGACACA CGACGGGACT CTGGTTCTGA TACAGAGACC AACACCGATT 120
GTGACGGAGA AGATTTGCCT CTTCTTCTGC TACCTGCTCC TCCCGGCCAC TTCGAAGAAG 180
GAGAGAGAGT TTTAGCCAAA CACAGTGATT GCTTCTACGA AGCCAAGGTT CTTAAAGTTG 240
AATTTAAAGA CAATGAATGG AAATATTTTG TGCATTACAT TGGTTGGAAC AAAAGTTGGG 300
ACGAATGGAT AAGGCTGGAC TGTCTGTTGA AACATTCAGA TGAGAATATT GAGAAACAGA 360
AAGAACAGGG TTTGAAACAG CAAGGGATTA AGAGTGCTAT GGCTTGGAAA GTGTCAAAGA 420
TGAAACCTAG AAGCCCTAAT GTTGCTAGAG GAAGAAAGCG GAAGCAAGAT TCTGTTGATA 480
CGGAGAAGAA TGTGCTTCCC TCTGACAACC TTTTAAGTTT CAATATTCCA CCAGCATTAA 540
GGAAGCAACT TCTTGACGAT TTTGAATTTG TTACTCAGAT GCAGAAGCTT GTGCAACTTC 600
CGCGTTCTCC AAATGTGGAT GGCATCTTGA AGAAGTACAT TGACAGCCAA ATGAAGAAAC 660
ATGGCAGGGT AACAGATTCA TTAGAGGAAA TTCTGAAAGG CTTGCGTTGC TACTTTGACA 720
AAGCTTTACC GGTGATGTTG CTTTACAACA ATGAACGGAA GCAGTACGAG GAATCCGTAT 780
CAGGGGGTGT TTCTCCTTCA ACTGTGTACG GAGCAGAGCA TTTGTTGCGA CTCTTTGTGA 840
AATTACCGGA GTTGCTAGTA CATGTGAATA TGGCAGAAGA GACATTGAAG GAATTGCAGG 900
ACAACTTTGT TGATATTCTC AGGTTCTTGA GGAAGAATCA GAGTGTGCTT TTTGTATCGA 960
CATACAAAGC AGTGGAAGAA ATGGAGAAGA AAGAAGGTTA GGAAATTGTG CCTAATGACG 1020
TGTTCTTGTA AGTATGTGCA GCGAATCTTC TCTTTGTAGT ATTTTGTAAC GAGACCTAAG 1080
ACCATCCTGA CCATCCTTAT TGATGGTCTC TTAACATAAC TCTTATGTTA AGAGATATGT 1140
CTTATAATTA ACAAAAGTGA CTTAAAGTCT CTTATATAAG AAATTTTGTT AGTTATAAAA 1200
CATGTCTCTT AGCATAAGAA TTGTTTTAAG AGATCATCAA TAATGATGAT CTAAGAACTA 1260
TTATACTATG TTCCGTCTCG ATTTTGAAAG TACTTAAACG TCGTTATCGT GTTTGTCTC 1320
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
--
Interpro

IPR014002--Agenet_dom_plant
IPR000953--Chromo/shadow_dom
IPR016197--Chromodomain-like
IPR008676--MRG
IPR026541--MRG_dom
IPR025995--Tudor-knot
PROSITE

PS51640--MRG
Pfam

PF05712--MRG
PF11717--Tudor-knot
Gene Ontology

GO:0000123--C:histone acetyltransferase complex
GO:0005634--C:nucleus
GO:1990188--F:euchromatin binding
GO:0006338--P:chromatin remodeling
GO:0043967--P:histone H4 acetylation
GO:0048510--P:regulation of timing of transition from vegetative to reproductive phase
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Thc-0003 EOX91556 Theobroma cacao 53 1e-83 306
WERAM-Glm-0056 GLYMA06G04620.1 Glycine max 54 2e-82 303
WERAM-Pot-0089 POPTR_0007s10460.1 Populus trichocarpa 56 4e-82 301
WERAM-Mua-0073 GSMUA_Achr4P12960_001 Musa acuminata 56 6e-82 301
WERAM-Arl-0141 scaffold_700360.1 Arabidopsis lyrata 51 8e-80 294
WERAM-Brr-0062 Bra011751.1-P Brassica rapa 51 2e-78 290
WERAM-Sol-0036 Solyc02g092910.2.1 Solanum lycopersicum 50 2e-78 289
WERAM-Prp-0070 EMJ06657 Prunus persica 46 9e-74 274
WERAM-Sot-0079 PGSC0003DMT400064229 Solanum tuberosum 52 5e-73 271
WERAM-Aet-0017 EMT06876 Aegilops tauschii 42 4e-58 222
WERAM-Tum-0023 CAZ84135 Tuber melanosporum 38 1e-40 164
WERAM-Bot-0105 ENSBTAP00000014581.5 Bos taurus 37 1e-36 150
WERAM-Asni-0012 CADANGAP00004222 Aspergillus niger 34 2e-36 150
WERAM-Orn-0162 ENSONIP00000016650.1 Oreochromis niloticus 33 2e-36 150
WERAM-Gaga-0083 ENSGALP00000032974.3 Gallus gallus 35 3e-36 149
WERAM-Dan-0023 ENSDNOP00000002194.3 Dasypus novemcinctus 36 3e-36 149
WERAM-Dar-0092 ENSDARP00000112985.1 Danio rerio 33 3e-36 149
WERAM-Asm-0023 ENSAMXP00000002832.1 Astyanax mexicanus 33 5e-36 149
WERAM-Aso-0013 CADAORAP00001673 Aspergillus oryzae 34 2e-35 147
WERAM-Ran-0248 ENSRNOP00000075745.1 Rattus norvegicus 34 3e-35 146
WERAM-Poa-0059 ENSPPYP00000007607.2 Pongo abelii 34 3e-35 146
WERAM-Caj-0017 ENSCJAP00000004116.2 Callithrix jacchus 34 3e-35 146
WERAM-Meg-0107 ENSMGAP00000010790.1 Meleagris gallopavo 34 3e-35 146
WERAM-Orc-0185 ENSOCUP00000016187.1 Oryctolagus cuniculus 34 4e-35 145
WERAM-Gaa-0052 ENSGACP00000006878.1 Gasterosteus aculeatus 34 5e-35 145
WERAM-Leo-0142 ENSLOCP00000017293.1 Lepisosteus oculatus 34 6e-35 145
WERAM-Fec-0161 ENSFCAP00000019835.1 Felis catus 33 6e-35 145
WERAM-Pof-0110 ENSPFOP00000009458.2 Poecilia formosa 33 6e-35 145
WERAM-Ten-0100 ENSTNIP00000011271.1 Tetraodon nigroviridis 34 7e-35 145
WERAM-Lac-0146 ENSLACP00000016822.1 Latimeria chalumnae 35 8e-35 145
WERAM-Xim-0038 ENSXMAP00000003628.1 Xiphophorus maculatus 34 9e-35 144
WERAM-Sah-0200 ENSSHAP00000021731.1 Sarcophilus harrisii 34 1e-34 144
WERAM-Xet-0054 ENSXETP00000017126.3 Xenopus tropicalis 32 2e-34 143
WERAM-Gam-0087 ENSGMOP00000008960.1 Gadus morhua 33 2e-34 143
WERAM-Spr-0011 CBQ68343 Sporisorium reilianum 31 3e-34 142
WERAM-Anc-0150 ENSACAP00000014061.2 Anolis carolinensis 34 3e-34 142
WERAM-Eqc-0042 ENSECAP00000006422.1 Equus caballus 34 1e-33 141
WERAM-Asfu-0038 CADAFUAP00008363 Aspergillus fumigatus 34 1e-33 140
WERAM-Myl-0017 ENSMLUP00000001606.2 Myotis lucifugus 33 2e-33 140
WERAM-Coi-0009 EAS36116 Coccidioides immitis 31 3e-33 139
WERAM-Asn-0032 CADANIAP00008637 Aspergillus nidulans 33 4e-33 139
WERAM-Tar-0185 ENSTRUP00000038533.1 Takifugu rubripes 33 4e-33 139
WERAM-Asc-0018 CADACLAP00004414 Aspergillus clavatus 33 7e-32 135
WERAM-Pes-0161 ENSPSIP00000019260.1 Pelodiscus sinensis 32 1e-31 134
WERAM-Mod-0094 ENSMODP00000014403.2 Monodelphis domestica 31 3e-31 133
WERAM-Orla-0021 ENSORLP00000002554.1 Oryzias latipes 30 4e-31 132
WERAM-Tag-0122 ENSTGUP00000010081.1 Taeniopygia guttata 31 4e-31 132
WERAM-Otg-0218 ENSOGAP00000018835.1 Otolemur garnettii 32 2e-30 130
WERAM-Asf-0006 CADAFLAP00002044 Aspergillus flavus 31 2e-30 130
WERAM-Sus-0018 ENSSSCP00000001932.2 Sus scrofa 31 6e-30 128
WERAM-Tut-0191 ENSTTRP00000015743.1 Tursiops truncatus 31 7e-30 128
WERAM-Pat-0055 ENSPTRP00000051331.1 Pan troglodytes 31 9e-30 128
WERAM-Nol-0090 ENSNLEP00000010671.1 Nomascus leucogenys 31 9e-30 128
WERAM-Hos-0222 ENSP00000331310.5 Homo sapiens 31 9e-30 128
WERAM-Gog-0191 ENSGGOP00000016418.2 Gorilla gorilla 31 9e-30 128
WERAM-Crn-0021 AAW44213 Cryptococcus neoformans 33 9e-30 128
WERAM-Loa-0095 ENSLAFP00000008255.3 Loxodonta africana 31 9e-30 128
WERAM-Ict-0118 ENSSTOP00000011915.2 Ictidomys tridecemlineatus 31 9e-30 128
WERAM-Mum-0212 ENSMUSP00000082346.5 Mus musculus 31 9e-30 128
WERAM-Mam-0209 ENSMMUP00000030192.2 Macaca mulatta 31 1e-29 128
WERAM-Cap-0042 ENSCPOP00000003411.2 Cavia porcellus 31 1e-29 127
WERAM-Anp-0039 ENSAPLP00000004318.1 Anas platyrhynchos 31 1e-29 127
WERAM-Mup-0177 ENSMPUP00000015319.1 Mustela putorius furo 30 1e-28 124
WERAM-Aim-0138 ENSAMEP00000013010.1 Ailuropoda melanoleuca 30 3e-28 123
WERAM-Caf-0148 ENSCAFP00000020818.3 Canis familiaris 30 3e-28 123
WERAM-Fia-0071 ENSFALP00000005346.1 Ficedula albicollis 31 3e-28 123
WERAM-Yal-0008 CAG80821 Yarrowia lipolytica 30 9e-28 121
WERAM-Ova-0157 ENSOARP00000015639.1 Ovis aries 30 1e-27 120
WERAM-Vip-0092 ENSVPAP00000008230.1 Vicugna pacos 30 2e-27 120
WERAM-Cis-0080 ENSCSAVP00000017617.1 Ciona savignyi 29 3e-26 116
WERAM-Asg-0009 AAS51868 Ashbya gossypii 26 6e-22 102
WERAM-Ect-0071 ENSETEP00000007825.1 Echinops telfairi 33 1e-21 100
WERAM-Chh-0066 ENSCHOP00000007156.1 Choloepus hoffmanni 34 3e-21 100
WERAM-Prc-0160 ENSPCAP00000015337.1 Procavia capensis 33 1e-20 97.8
WERAM-Soa-0075 ENSSARP00000007155.1 Sorex araneus 32 2e-20 97.1
WERAM-Tas-0045 ENSTSYP00000004433.1 Tarsius syrichta 33 2e-20 97.1
WERAM-Mim-0030 ENSMICP00000002766.1 Microcebus murinus 33 2e-20 97.1
WERAM-Ere-0064 ENSEEUP00000005345.1 Erinaceus europaeus 33 2e-20 97.1
WERAM-Paa-0050 ENSPANP00000004934.1 Papio anubis 33 3e-20 96.7
WERAM-Tub-0030 ENSTBEP00000003706.1 Tupaia belangeri 32 3e-20 96.7
WERAM-Ptv-0177 ENSPVAP00000015442.1 Pteropus vampyrus 32 4e-20 96.3
WERAM-Chs-0006 ENSCSAP00000017681.1 Chlorocebus sabaeus 33 4e-20 96.3
WERAM-Ved-0026 EGY15805 Verticillium dahliae 35 2e-19 94.0
WERAM-Ora-0118 ENSOANP00000023079.2 Ornithorhynchus anatinus 38 3e-19 93.2
WERAM-Ocp-0117 ENSOPRP00000011535.1 Ochotona princeps 28 1e-18 90.9
WERAM-Sac-0051 YPR023C Saccharomyces cerevisiae 36 2e-16 84.3
WERAM-Dio-0073 ENSDORP00000007264.1 Dipodomys ordii 33 3e-16 83.6
WERAM-Mae-0068 ENSMEUP00000006768.1 Macropus eugenii 32 1e-14 78.2
WERAM-Drm-0029 FBpp0082579 Drosophila melanogaster 34 3e-14 76.6
WERAM-Pem-0072 ENSPMAP00000007740.1 Petromyzon marinus 39 7e-12 68.9
Created Date 25-Jun-2016