JHDM3_JMJD2: The JHDM3_JMJD2 group of proteins has orthologues from yeast to humans. In higher eukaryotes, proteins of this family contain JmjN, PHD and Tudor domains in addition to the JmjC domain. There are four JHDM3_JMJD2 genes (JHDM3A_JMJD2A, JMJD2B, JMJD2C and JMJD2D) in the human genome, each of which has orthologues in the mouse. JHDM3A_JMJD2A was originally identified as a transcriptional repressor associated with the NCoR corepressor complex, but has also been shown to physically interact with RB to repress E2F target genes. More recently, it was suggested that the tandem Tudor domain of JHDM3A_JMJD2A potentially contains a chromatin targeting module that directly binds methylated H3K4, H3K9 and H4K20. (1)

Reference
1. Klose RJ,Kallin EM,Zhang Y (2008)JmjC-domain-containing proteins and histone demethylation. Nat Rev Genet., 7:715-727. PMID: 16983801.

    JmjC_only: The seventh group that we discuss contains several JmjC domain- containing proteins that, apart from the JmjC domain, contain no other recognizable protein domains. This group forms its own branch that is based on homology within the JmjC domain, and includes all of the JmjC-domain proteins that are known to localize to the cytoplasm (FIH, PLA2G4B and HSPBAP1). We propose that these proteins, of which only the MINA53/NO66 group (see below) has orthologues in yeast, might have diverged in higher eukaryotes to carry out functions that are independent of histone demethylation. (1)

Reference
1. Klose RJ,Kallin EM,Zhang Y (2012)JmjC-domain-containing proteins and histone demethylation. Nat Rev Genet., 7:715-727. PMID: 16983801.