JARID: The JARID group of proteins contains two subgroups: JARID1 and JARID2. In higher eukaryotes, the JARID1 subgroup contains JmjN, AT-rich interactive, C5HC2-zinc-finger and PHD-finger domains. The JARID2 subgroup does not contain PHD domains, and its Drosophila homologue lacks the C5HC2-zinc-finger domain. The mammalian JARID1 homologues can function as transcriptional co-activators or corepressors, indicating that their substrate specificity could be uniquely tailored to their distinct functions in modulating transcription. (1)

Reference
1. Klose RJ,Kallin EM,Zhang Y (2010)JmjC-domain-containing proteins and histone demethylation. Nat Rev Genet., 7:715-727. PMID: 16983801.

    JHDM2: The JHDM2 family of proteins have orthologues from flies to humans; they possess JmjC and modified zinc finger domains. The mammalian JHDM2 family is comprised of four human proteins: hairless (HR), JHDM2A, JHDM2B, and JHDM2C. HR was originally identified in mice, and its mutation results in universal congenital alopecia. Mutation in its human homologue also causes hereditary alopecia. HR is expressed in the skin and the brain, where it probably functions as a corepressor of the thyroid hormone receptor. (1)

Reference
1. Klose RJ,Kallin EM,Zhang Y (2007)JmjC-domain-containing proteins and histone demethylation. Nat Rev Genet., 7:715-727. PMID: 16983801.

    JmjC_only: The seventh group that we discuss contains several JmjC domain- containing proteins that, apart from the JmjC domain, contain no other recognizable protein domains. This group forms its own branch that is based on homology within the JmjC domain, and includes all of the JmjC-domain proteins that are known to localize to the cytoplasm (FIH, PLA2G4B and HSPBAP1). We propose that these proteins, of which only the MINA53/NO66 group (see below) has orthologues in yeast, might have diverged in higher eukaryotes to carry out functions that are independent of histone demethylation. (1)

Reference
1. Klose RJ,Kallin EM,Zhang Y (2012)JmjC-domain-containing proteins and histone demethylation. Nat Rev Genet., 7:715-727. PMID: 16983801.

    PHF2_PHF8: The PHF2_PHF8 group members are found in worms, mice and humans, and contain a PHD domain in addition to a JmjC domain. The subcellular localization of these proteins remains unknown, although most of them contain predicted nuclear localization signals (NLSs), indicating a role in nuclear function. Northern blot analysis indicates that PHF2 is ubiquitously expressed, and in situ hybridization has shown that the majority of PHF2 gene expression is concentrated in the embryonic neural tube and root ganglia in mice. (1)

Reference
1. Klose RJ,Kallin EM,Zhang Y (2009)JmjC-domain-containing proteins and histone demethylation. Nat Rev Genet., 7:715-727. PMID: 16983801.