p300_CBP: The global transcriptional co-activator p300_CBP is a potent HAT that plays essential roles in the nervous system development. p300_CBP HAT is recruited to DNA by direct interaction with specific transcription factors, which enhances transcriptional activity by acetylation of histones proximal to the promoter region. (1)

Reference
1. Sterner, D.E.&Berger, S.L.Acetylation of histones and transcription-related factors. Microbiol. Mol. Biol. Rev.2000;64(2):435-459. PMID: 10839822.