Classification: Me_Reader Ankyrin※ Ankyrin family introduction
Me_Reader Ankyrin
Ankyrin: Owing to extensive intermolecular contacts, the ankyrin repeats of G9a and GLP and the BAH domain of ORC1 show high specificity for di- or monomethylated H3K9 and H4K20me2, respectively. The H3K9me2 peptide is sandwiched between the β-turns and α-helices of the fourth and fifth ankyrin repeats, whereas K9me2 fits into the aromatic cage also containing a glutamate. (1)
Reference
1. Musselman CA, Lalonde ME, Cote J, Kutateladze TG.Perceiving the epigenetic landscape through histone readers. Nat Struct Mol Biol.2012;19(12):1218-27. PMID: 23211769.
Me_Reader Ankyrin
| Aspergillus fumigatus (1) | Bos taurus (2) | Callithrix jacchus (1) |
| Canis familiaris (1) | Cavia porcellus (2) | Chlorocebus sabaeus (2) |
| Danio rerio (1) | Dasypus novemcinctus (1) | Equus caballus (1) |
| Erinaceus europaeus (1) | Felis catus (1) | Gorilla gorilla (2) |
| Homo sapiens (9) | Ictidomys tridecemlineatus (1) | Loxodonta africana (1) |
| Macaca mulatta (2) | Meleagris gallopavo (1) | Monodelphis domestica (1) |
| Mus musculus (3) | Mustela putorius furo (1) | Nomascus leucogenys (1) |
| Oryctolagus cuniculus (1) | Otolemur garnettii (2) | Ovis aries (1) |
| Pan troglodytes (2) | Papio anubis (2) | Pelodiscus sinensis (2) |
| Pongo abelii (2) | Rattus norvegicus (1) | Sarcophilus harrisii (1) |
| Sus scrofa (1) | Takifugu rubripes (2) | Tursiops truncatus (1) |