Classification:      HDM      LSD1_KDM1

※ LSD1_KDM1 family introduction

    LSD1_KDM1: LSD1 (Lysine specific demethylase1) was the founding member of a second class of enzymes that directly reverse histone H3K4 or H3K9 modifications by an oxidative demethylation reaction in which flavin is a cofactor. Full enzymatic activity of LSD1 requires its association with other proteins, such as the CoREST (restin corepressor) complex, indicating that regulatory subunits can have a role in modulating demethylase activity. (1)

1. Klose RJ,Kallin EM,Zhang Y (2013)JmjC-domain-containing proteins and histone demethylation. Nat Rev Genet., 7:715-727. PMID: 16983801.

    HDM LSD1_KDM1 

  Ailuropoda melanoleuca (1)  Callithrix jacchus (1)  Canis familiaris (1)
  Equus caballus (1)  Felis catus (1)  Homo sapiens (1)
  Macaca mulatta (1)  Mus musculus (1)  Myotis lucifugus (1)
  Oryctolagus cuniculus (1)  Ovis aries (1)  Schizosaccharomyces pombe (2)