Classification: HDAC Class-II※ Class-II family introduction
HDAC Class-II
Class-II: Class II HDACs share homology with yeast Hda1, and are sub-classified into Classes IIa and IIb. The former group contains HDACs 4, 5, 7, and 9, and HDACs 6 and 10 belong to group IIb. (1)
Class IIa HDACs shuttle between the nucleus and cytoplasm, This group of HDACs regulate the activity of transcription factors. Class IIb HDACs seem to have primarily cytoplasmic roles, with HDAC6 deacetylatingalpha-tubulin and functioning as part of protein aggresome formation and processing.
Reference
1. Koeneke, E., Witt, O., & Oehme, I.HDAC Family Members Intertwined in the Regulation of Autophagy: A Druggable Vulnerability in Aggressive Tumor Entities. Cells.2015;4(2):135-168. PMID: 25915736.
HDAC Class-II