Triticum urartu      HMT      SUV39

※ SUV39 family introduction

    SUV39: The Su(var)3-9 gene was originally identified in a genetic screen as a suppressor of position effect variegation in Drosophila. This was the first hint that the Su(var)3-9 protein might be involved in regulating chromatin structure. In mice, there are two highly related homologues of the Drosophila Su(var)3-9, Suv39h1 and Suv39h2. Following the identification of Suv39h1 as a lysine methyltransferase capable of methylating Lys9 of histone H3 (H3K9), confirmation that this protein can modulate chromatin architecture came with the finding that it creates a specific binding site for the heterochromatin protein HP1. As Suv39h1 and HP1 interact, it is thought that Suv39h1 methylating H3 K9, and then HP1 binding to the methylated H3, forms a positive feedback loop allowing HP1 and H3 K9 methylation to spread along chromatin, generating repressive heterochromatin in the process. (1)

Reference
1. Schneider R, Bannister AJ, Kouzarides T.Unsafe SETs: histone lysine methyltransferases and cancer. Trends Biochem Sci.2002;27(8):396-402. PMID: 12151224.



There are 14 genes.  Reviewed (0 or Unreviewed (14

No.StatusWERAM IDGene/Alias Name
1
WERAM-Tru-0003
TRIUR3_02327
2
WERAM-Tru-0012
3
WERAM-Tru-0025
TRIUR3_13930
4
WERAM-Tru-0035
TRIUR3_17558
5
WERAM-Tru-0039
TRIUR3_19455
6
WERAM-Tru-0044
TRIUR3_20106
7
WERAM-Tru-0049
TRIUR3_21530
8
WERAM-Tru-0055
TRIUR3_22796
9
WERAM-Tru-0063
TRIUR3_25291
10
WERAM-Tru-0079
11
WERAM-Tru-0080
TRIUR3_29767
12
WERAM-Tru-0091
TRIUR3_32787
13
WERAM-Tru-0094
14
WERAM-Tru-0095
TRIUR3_33604