Solanum tuberosum      HMT      SUV39

※ SUV39 family introduction

    SUV39: The Su(var)3-9 gene was originally identified in a genetic screen as a suppressor of position effect variegation in Drosophila. This was the first hint that the Su(var)3-9 protein might be involved in regulating chromatin structure. In mice, there are two highly related homologues of the Drosophila Su(var)3-9, Suv39h1 and Suv39h2. Following the identification of Suv39h1 as a lysine methyltransferase capable of methylating Lys9 of histone H3 (H3K9), confirmation that this protein can modulate chromatin architecture came with the finding that it creates a specific binding site for the heterochromatin protein HP1. As Suv39h1 and HP1 interact, it is thought that Suv39h1 methylating H3 K9, and then HP1 binding to the methylated H3, forms a positive feedback loop allowing HP1 and H3 K9 methylation to spread along chromatin, generating repressive heterochromatin in the process. (1)

Reference
1. Schneider R, Bannister AJ, Kouzarides T.Unsafe SETs: histone lysine methyltransferases and cancer. Trends Biochem Sci.2002;27(8):396-402. PMID: 12151224.



There are 14 genes.  Reviewed (0 or Unreviewed (14

No.StatusWERAM IDGene/Alias Name
1
WERAM-Sot-0005
PGSC0003DMG400001557
2
WERAM-Sot-0021
PGSC0003DMG400007185
3
WERAM-Sot-0049
PGSC0003DMG400017150
4
WERAM-Sot-0059
PGSC0003DMG400020151
5
WERAM-Sot-0063
PGSC0003DMG400021004
6
WERAM-Sot-0064
PGSC0003DMG400021005
7
WERAM-Sot-0065
PGSC0003DMG400021006
8
WERAM-Sot-0080
PGSC0003DMG400026247
9
WERAM-Sot-0083
PGSC0003DMG400026579
10
WERAM-Sot-0087
PGSC0003DMG400029251
11
WERAM-Sot-0091
PGSC0003DMG400030077
12
WERAM-Sot-0094
PGSC0003DMG400031305
13
WERAM-Sot-0095
PGSC0003DMG400031306
14
WERAM-Sot-0096
PGSC0003DMG400031307