Physcomitrella patens      HMT      SUV39

※ SUV39 family introduction

    SUV39: The Su(var)3-9 gene was originally identified in a genetic screen as a suppressor of position effect variegation in Drosophila. This was the first hint that the Su(var)3-9 protein might be involved in regulating chromatin structure. In mice, there are two highly related homologues of the Drosophila Su(var)3-9, Suv39h1 and Suv39h2. Following the identification of Suv39h1 as a lysine methyltransferase capable of methylating Lys9 of histone H3 (H3K9), confirmation that this protein can modulate chromatin architecture came with the finding that it creates a specific binding site for the heterochromatin protein HP1. As Suv39h1 and HP1 interact, it is thought that Suv39h1 methylating H3 K9, and then HP1 binding to the methylated H3, forms a positive feedback loop allowing HP1 and H3 K9 methylation to spread along chromatin, generating repressive heterochromatin in the process. (1)

Reference
1. Schneider R, Bannister AJ, Kouzarides T.Unsafe SETs: histone lysine methyltransferases and cancer. Trends Biochem Sci.2002;27(8):396-402. PMID: 12151224.



There are 10 genes.  Reviewed (0 or Unreviewed (10

No.StatusWERAM IDGene/Alias Name
1
WERAM-Php-0008
PHYPADRAFT_133637
2
WERAM-Php-0028
PHYPADRAFT_118539
3
WERAM-Php-0033
PHYPADRAFT_186998
4
WERAM-Php-0042
HAC1501 PHYPADRAFT_10108
5
WERAM-Php-0058
PHYPADRAFT_3159
6
WERAM-Php-0082
CHR1512 PHYPADRAFT_120666
7
WERAM-Php-0102
SDG1521 PHYPADRAFT_227869
8
WERAM-Php-0105
SDG1520 PHYPADRAFT_101365
9
WERAM-Php-0112
SDG1526 PHYPADRAFT_27014
10
WERAM-Php-0132
PHYPADRAFT_131736