Oryza sativa      HMT      SUV39

※ SUV39 family introduction

    SUV39: The Su(var)3-9 gene was originally identified in a genetic screen as a suppressor of position effect variegation in Drosophila. This was the first hint that the Su(var)3-9 protein might be involved in regulating chromatin structure. In mice, there are two highly related homologues of the Drosophila Su(var)3-9, Suv39h1 and Suv39h2. Following the identification of Suv39h1 as a lysine methyltransferase capable of methylating Lys9 of histone H3 (H3K9), confirmation that this protein can modulate chromatin architecture came with the finding that it creates a specific binding site for the heterochromatin protein HP1. As Suv39h1 and HP1 interact, it is thought that Suv39h1 methylating H3 K9, and then HP1 binding to the methylated H3, forms a positive feedback loop allowing HP1 and H3 K9 methylation to spread along chromatin, generating repressive heterochromatin in the process. (1)

Reference
1. Schneider R, Bannister AJ, Kouzarides T.Unsafe SETs: histone lysine methyltransferases and cancer. Trends Biochem Sci.2002;27(8):396-402. PMID: 12151224.



There are 14 genes.  Reviewed (0 or Unreviewed (14

No.StatusWERAM IDGene/Alias Name
1
WERAM-Ors-0004
Os01g0772150 OSNPB_010772150
2
WERAM-Ors-0005
OsJ_03828
3
WERAM-Ors-0010
Os01g0927000 OSJNBa0093F16.26 OSNPB_010927000
4
WERAM-Ors-0024
Os02g0621100 Os02g0621100 OJ1234_B11.9 OJ1372_D06.34 OsJ_07564 OSNPB_020621100
5
WERAM-Ors-0025
OsJ_08098
6
WERAM-Ors-0043
OsJ_15653
7
WERAM-Ors-0051
Os05g0490700 OsJ_19021 OSJNBa0088I06.5 OSNPB_050490700
8
WERAM-Ors-0067
Os07g0435900 Os07g0435900 OSJNBb0095H08.7 OSNPB_070435900
9
WERAM-Ors-0082
Os08g0400200
10
WERAM-Ors-0086
P0705A05.133 Os08g0565700 OsJ_28318 OSJNBa0044E16.17 OSNPB_080565700
11
WERAM-Ors-0090
Os09g0362900 OJ1506_A04.14 OSNPB_090362900
12
WERAM-Ors-0098
Os11g0131600 OSNPB_110131600
13
WERAM-Ors-0105
Os11g0602200 LOC_Os11g38900 Os11g0602200 OSNPB_110602200
14
WERAM-Ors-0106
Os12g0128450 OSNPB_120128450