Vitis vinifera      HMT      SET1

※ SET1 family introduction

    SET1: The SET1 gene in the budding yeast Saccharomyces cerevisiae was discovered by several laboratories as encoding the first known H3K4 methyltransferase, a catalytic function performed through its conserved SET domain. Yeast Set1, like its orthologs in higher eukaryotes (SET1A/B in humans), is recruited to chromatin by the serine 5-phosphorylated C-terminal domain of RNA polymerase II (pol II). This interaction with the initiating form of pol II results in the occupancy of Set1 near the 5’-end of active genes, which correlates closely with the peak of H3K4me3. (1)

    In metazoans, SET1A/B proteins seem to function analogously to yeast Set1 in performing the majority of transcription-coupled H3K4 methylation found at active genes, presumably through co-transcriptional recruitment. Unlike their yeast counterpart, human SET1A/B proteins are also recruited to chromatin via an interaction with non-methylated CpG island sequences, mediated by the SET1A/B-associated protein CFP1.

Reference
1. Ernst P, Vakoc CR.WRAD: enabler of the SET1-family of H3K4 methyltransferases. Brief Funct Genomics.2012;11(3):217-226. PMID: 22652693.



There are 15 genes.  Reviewed (0 or Unreviewed (15

No.StatusWERAM IDGene/Alias Name
1
WERAM-Viv-0018
VIT_04s0023g00980
2
WERAM-Viv-0020
VIT_04s0044g00950
3
WERAM-Viv-0030
VIT_05s0124g00250
4
WERAM-Viv-0043
VIT_07s0005g01490
5
WERAM-Viv-0045
VIT_07s0031g00320
6
WERAM-Viv-0070
VIT_11s0037g00880
7
WERAM-Viv-0079
VIT_12s0059g02740
8
WERAM-Viv-0095
VIT_15s0046g00760
9
WERAM-Viv-0099
VIT_16s0039g00740
10
WERAM-Viv-0100
VIT_16s0098g00350
11
WERAM-Viv-0102
VIT_16s0098g01510
12
WERAM-Viv-0111
VIT_18s0001g01700
13
WERAM-Viv-0114
VIT_18s0072g00200
14
WERAM-Viv-0115
VIT_18s0072g00210
15
WERAM-Viv-0116
VIT_18s0072g00220