Oryza sativa      HMT      SET1

※ SET1 family introduction

    SET1: The SET1 gene in the budding yeast Saccharomyces cerevisiae was discovered by several laboratories as encoding the first known H3K4 methyltransferase, a catalytic function performed through its conserved SET domain. Yeast Set1, like its orthologs in higher eukaryotes (SET1A/B in humans), is recruited to chromatin by the serine 5-phosphorylated C-terminal domain of RNA polymerase II (pol II). This interaction with the initiating form of pol II results in the occupancy of Set1 near the 5’-end of active genes, which correlates closely with the peak of H3K4me3. (1)

    In metazoans, SET1A/B proteins seem to function analogously to yeast Set1 in performing the majority of transcription-coupled H3K4 methylation found at active genes, presumably through co-transcriptional recruitment. Unlike their yeast counterpart, human SET1A/B proteins are also recruited to chromatin via an interaction with non-methylated CpG island sequences, mediated by the SET1A/B-associated protein CFP1.

Reference
1. Ernst P, Vakoc CR.WRAD: enabler of the SET1-family of H3K4 methyltransferases. Brief Funct Genomics.2012;11(3):217-226. PMID: 22652693.



There are 12 genes.  Reviewed (0 or Unreviewed (12

No.StatusWERAM IDGene/Alias Name
1
WERAM-Ors-0001
Os01g0218800 Os01g0218800 OSNPB_010218800 P0489G09.14
2
WERAM-Ors-0014
Os02g0122700 OSNPB_020122700
3
WERAM-Ors-0021
Os02g0554000 OSNPB_020554000
4
WERAM-Ors-0025
OsJ_08098
5
WERAM-Ors-0030
Os03g0307800 LOC_Os03g19480 Os03g0307800 OsJ_10569 OSNPB_030307800
6
WERAM-Ors-0041
Os04g0429100
7
WERAM-Ors-0055
Os06g0275500 Os06g0275500 OSNPB_060275500 P0038C05.29 P0676F10.40
8
WERAM-Ors-0079
Os08g0180100 OSNPB_080180100
9
WERAM-Ors-0087
P0406E03.49-1 Os09g0134500 OSNPB_090134500
10
WERAM-Ors-0088
OsJ_28789
11
WERAM-Ors-0096
Os09g0556700 OSNPB_090556700
12
WERAM-Ors-0112
LOC_Os12g41900 Os12g0613200 OSNPB_120613200