Ornithorhynchus anatinus      HMT      SET1

※ SET1 family introduction

    SET1: The SET1 gene in the budding yeast Saccharomyces cerevisiae was discovered by several laboratories as encoding the first known H3K4 methyltransferase, a catalytic function performed through its conserved SET domain. Yeast Set1, like its orthologs in higher eukaryotes (SET1A/B in humans), is recruited to chromatin by the serine 5-phosphorylated C-terminal domain of RNA polymerase II (pol II). This interaction with the initiating form of pol II results in the occupancy of Set1 near the 5’-end of active genes, which correlates closely with the peak of H3K4me3. (1)

    In metazoans, SET1A/B proteins seem to function analogously to yeast Set1 in performing the majority of transcription-coupled H3K4 methylation found at active genes, presumably through co-transcriptional recruitment. Unlike their yeast counterpart, human SET1A/B proteins are also recruited to chromatin via an interaction with non-methylated CpG island sequences, mediated by the SET1A/B-associated protein CFP1.

Reference
1. Ernst P, Vakoc CR.WRAD: enabler of the SET1-family of H3K4 methyltransferases. Brief Funct Genomics.2012;11(3):217-226. PMID: 22652693.



There are 10 genes.  Reviewed (0 or Unreviewed (10

No.StatusWERAM IDGene/Alias Name
1
WERAM-Ora-0001
KMT2D
2
WERAM-Ora-0003
EZH2
3
WERAM-Ora-0032
WHSC1L1
4
WERAM-Ora-0065
KMT2C
5
WERAM-Ora-0074
NSD1
6
WERAM-Ora-0098
KMT2B
7
WERAM-Ora-0110
8
WERAM-Ora-0120
9
WERAM-Ora-0125
KMT5A
10
WERAM-Ora-0126
SUV39H2