Loxodonta africana      HMT      SET1

※ SET1 family introduction

    SET1: The SET1 gene in the budding yeast Saccharomyces cerevisiae was discovered by several laboratories as encoding the first known H3K4 methyltransferase, a catalytic function performed through its conserved SET domain. Yeast Set1, like its orthologs in higher eukaryotes (SET1A/B in humans), is recruited to chromatin by the serine 5-phosphorylated C-terminal domain of RNA polymerase II (pol II). This interaction with the initiating form of pol II results in the occupancy of Set1 near the 5’-end of active genes, which correlates closely with the peak of H3K4me3. (1)

    In metazoans, SET1A/B proteins seem to function analogously to yeast Set1 in performing the majority of transcription-coupled H3K4 methylation found at active genes, presumably through co-transcriptional recruitment. Unlike their yeast counterpart, human SET1A/B proteins are also recruited to chromatin via an interaction with non-methylated CpG island sequences, mediated by the SET1A/B-associated protein CFP1.

Reference
1. Ernst P, Vakoc CR.WRAD: enabler of the SET1-family of H3K4 methyltransferases. Brief Funct Genomics.2012;11(3):217-226. PMID: 22652693.



There are 15 genes.  Reviewed (0 or Unreviewed (15

No.StatusWERAM IDGene/Alias Name
1
WERAM-Loa-0022
EZH2
2
WERAM-Loa-0040
SETD2
3
WERAM-Loa-0059
SUV39H1
4
WERAM-Loa-0062
NSD1
5
WERAM-Loa-0087
WHSC1
6
WERAM-Loa-0099
KMT2D
7
WERAM-Loa-0104
EZH1
8
WERAM-Loa-0119
KMT5A
9
WERAM-Loa-0134
WHSC1L1
10
WERAM-Loa-0136
KMT2A
11
WERAM-Loa-0170
KMT2B
12
WERAM-Loa-0183
SUV39H2
13
WERAM-Loa-0185
SETD1A
14
WERAM-Loa-0190
SETD1B
15
WERAM-Loa-0207