Oryctolagus cuniculus      HDAC      SIR2

※ SIR2 family introduction

    SIR2: Class III HDACs are sirtuin family enzymes. This class of proteins is related to the transcriptional repressor Sir2 (Silent information regulator 2) in the budding yeast. Yeast has five sirtuins including Sir2 and four homologs, Hst1-4 (Homolog of Sir two). The sirtuin deacetylases contain a conserved catalytic domain that is not related to deacetylase domain of other HDAC classes. Thus, the sirtuins catalyze deacetylation by a different mechanism that requires NAD+ as a cofactor. (1)

Reference
1. Jeon J. H., Lee Y. H.Histone acetylation in fungal pathogens of plants. Plant Pathol.J.2014;30(1):1-9. PMID: 25288980.



There are 5 genes.  Reviewed (0 or Unreviewed (5

No.StatusWERAM IDGene/Alias Name
1
WERAM-Orc-0069
SIRT5
2
WERAM-Orc-0096
SIRT1
3
WERAM-Orc-0113
SIRT4
4
WERAM-Orc-0194
Sirt3
5
WERAM-Orc-0210
SIRT2