Candida glabrata      HDAC      SIR2

※ SIR2 family introduction

    SIR2: Class III HDACs are sirtuin family enzymes. This class of proteins is related to the transcriptional repressor Sir2 (Silent information regulator 2) in the budding yeast. Yeast has five sirtuins including Sir2 and four homologs, Hst1-4 (Homolog of Sir two). The sirtuin deacetylases contain a conserved catalytic domain that is not related to deacetylase domain of other HDAC classes. Thus, the sirtuins catalyze deacetylation by a different mechanism that requires NAD+ as a cofactor. (1)

Reference
1. Jeon J. H., Lee Y. H.Histone acetylation in fungal pathogens of plants. Plant Pathol.J.2014;30(1):1-9. PMID: 25288980.



There are 4 genes.  Reviewed (0 or Unreviewed (4

No.StatusWERAM IDGene/Alias Name
1
WERAM-Cag-0008
SIR2/HST1 AO438_000641 AO439_000631 AO440_000590 AO441_000497
2
WERAM-Cag-0016
AO438_002329 AO439_002324 AO440_002248 AO441_002149
3
WERAM-Cag-0021
AO438_003407 AO439_003382 AO440_003313 AO441_003251
4
WERAM-Cag-0026
AO438_004245 AO439_004220 AO440_005189 AO440_005816 AO441_004089