Candida albicans      HDAC      SIR2

※ SIR2 family introduction

    SIR2: Class III HDACs are sirtuin family enzymes. This class of proteins is related to the transcriptional repressor Sir2 (Silent information regulator 2) in the budding yeast. Yeast has five sirtuins including Sir2 and four homologs, Hst1-4 (Homolog of Sir two). The sirtuin deacetylases contain a conserved catalytic domain that is not related to deacetylase domain of other HDAC classes. Thus, the sirtuins catalyze deacetylation by a different mechanism that requires NAD+ as a cofactor. (1)

Reference
1. Jeon J. H., Lee Y. H.Histone acetylation in fungal pathogens of plants. Plant Pathol.J.2014;30(1):1-9. PMID: 25288980.



There are 4 genes.  Reviewed (0 or Unreviewed (4

No.StatusWERAM IDGene/Alias Name
1
WERAM-Caa-0006
I503_00879
2
WERAM-Caa-0008
I503_01572 W5Q_01578
3
WERAM-Caa-0024
I503_04167
4
WERAM-Caa-0033
I503_05602