Ochotona princeps      HDAC      Class-II

※ Class-II family introduction

    Class-II: Class II HDACs share homology with yeast Hda1, and are sub-classified into Classes IIa and IIb. The former group contains HDACs 4, 5, 7, and 9, and HDACs 6 and 10 belong to group IIb. (1)

    Class IIa HDACs shuttle between the nucleus and cytoplasm, This group of HDACs regulate the activity of transcription factors. Class IIb HDACs seem to have primarily cytoplasmic roles, with HDAC6 deacetylatingalpha-tubulin and functioning as part of protein aggresome formation and processing.

Reference
1. Koeneke, E., Witt, O., & Oehme, I.HDAC Family Members Intertwined in the Regulation of Autophagy: A Druggable Vulnerability in Aggressive Tumor Entities. Cells.2015;4(2):135-168. PMID: 25915736.



There are 4 genes.  Reviewed (0 or Unreviewed (4

No.StatusWERAM IDGene/Alias Name
1
WERAM-Ocp-0057
HDAC6
2
WERAM-Ocp-0087
HDAC5
3
WERAM-Ocp-0101
HDAC7
4
WERAM-Ocp-0153
HDAC9