Canis familiaris      HDAC      Class-II

※ Class-II family introduction

    Class-II: Class II HDACs share homology with yeast Hda1, and are sub-classified into Classes IIa and IIb. The former group contains HDACs 4, 5, 7, and 9, and HDACs 6 and 10 belong to group IIb. (1)

    Class IIa HDACs shuttle between the nucleus and cytoplasm, This group of HDACs regulate the activity of transcription factors. Class IIb HDACs seem to have primarily cytoplasmic roles, with HDAC6 deacetylatingalpha-tubulin and functioning as part of protein aggresome formation and processing.

Reference
1. Koeneke, E., Witt, O., & Oehme, I.HDAC Family Members Intertwined in the Regulation of Autophagy: A Druggable Vulnerability in Aggressive Tumor Entities. Cells.2015;4(2):135-168. PMID: 25915736.



There are 6 genes.  Reviewed (0 or Unreviewed (6

No.StatusWERAM IDGene/Alias Name
1
WERAM-Caf-0004
HDAC10
2
WERAM-Caf-0031
HDAC9
3
WERAM-Caf-0101
HDAC7
4
WERAM-Caf-0133
HDAC4
5
WERAM-Caf-0149
HDAC5
6
WERAM-Caf-0161
HDAC6