Myotis lucifugus      HDAC      Class-I

※ Class-I family introduction

    Class-I: Class I HDACs share homology with the yeast Rpd3. This class includes HDACs 1, 2, 3, and 8, and its members are expressed ubiquitously in humans. Members 1, 2, and 3 are found in multi-protein repressor complexes in the nucleus, where they regulate gene expression. HDAC8 is found in both the nucleus and cytoplasm, and while it has not been found in any multi-protein complexes, it has been described to be involved in transcriptional repression. (1)

Reference
1. Koeneke, E., Witt, O., & Oehme, I.HDAC Family Members Intertwined in the Regulation of Autophagy: A Druggable Vulnerability in Aggressive Tumor Entities. Cells.2015;4(2):135-168. PMID: 25915736.



There are 14 genes.  Reviewed (0 or Unreviewed (14

No.StatusWERAM IDGene/Alias Name
1
WERAM-Myl-0003
HDAC10
2
WERAM-Myl-0009
HDAC7
3
WERAM-Myl-0035
LOC102442683
4
WERAM-Myl-0041
5
WERAM-Myl-0060
HDAC8
6
WERAM-Myl-0072
HDAC5
7
WERAM-Myl-0074
HDAC9
8
WERAM-Myl-0096
HDAC3
9
WERAM-Myl-0104
HDAC6
10
WERAM-Myl-0152
HDAC1
11
WERAM-Myl-0159
HDAC4
12
WERAM-Myl-0189
HDAC11
13
WERAM-Myl-0209
LOC102427151
14
WERAM-Myl-0215