Xenopus tropicalis      Ac_Reader      Bromodomain

※ Bromodomain family introduction

    Bromodomain: Bromodomains (BRDs) are protein interaction modules that exclusively recognize acetylation motifs. BRDs are evolutionarily conserved and present in diverse nuclear proteins comprising HATs (GCN5, PCAF), ATP-dependent chromatin-remodeling complexes (BAZ1B), helicases (SMARCA), methyltransferases (MLL, ASH1L), transcriptional coactivators (TRIM/TIF1, TAFs) transcriptional mediators (TAF1), nuclear-scaffolding proteins(PB1), and the BET family. Despite large sequence variations, all BRD modules share a conserved fold that comprises a left-handed bundle of four a helices, linked by loop regions of variablelength, which line the Kac binding site and determine binding specificity. (1)

Reference
1. P. Filippakopoulos, S. Picaud, M. Mangos, T. Keates, J.P. Lambert, D. Barsyte-Lovejoy, I. Felletar, R. Volkmer, S. Müller, T. Pawson,et al.Histone recognition and large-scale structural analysis of the human bromodomain family. Cell.2012;149(1):214-231. PMID: 22464331.



There are 35 genes.  Reviewed (0 or Unreviewed (35

No.StatusWERAM IDGene/Alias Name
1
WERAM-Xet-0003
cecr2
2
WERAM-Xet-0009
bptf
3
WERAM-Xet-0017
kat2a
4
WERAM-Xet-0044
brd8
5
WERAM-Xet-0052
baz2b
6
WERAM-Xet-0059
brdt
7
WERAM-Xet-0063
smarca4
8
WERAM-Xet-0068
crebbp
9
WERAM-Xet-0069
baz1b
10
WERAM-Xet-0078
trim24
11
WERAM-Xet-0079
phip
12
WERAM-Xet-0082
baz1a
13
WERAM-Xet-0088
brd4
14
WERAM-Xet-0089
brd9
15
WERAM-Xet-0091
pbrm1
16
WERAM-Xet-0094
kat2b
17
WERAM-Xet-0097
brd1
18
WERAM-Xet-0101
smarca2
19
WERAM-Xet-0109
zmynd11
20
WERAM-Xet-0111
brd2
21
WERAM-Xet-0115
atad2b
22
WERAM-Xet-0116
brd7
23
WERAM-Xet-0120
trim28
24
WERAM-Xet-0123
brd3
25
WERAM-Xet-0134
trim33
26
WERAM-Xet-0136
baz2a
27
WERAM-Xet-0142
brwd3
28
WERAM-Xet-0149
EP300
29
WERAM-Xet-0153
taf1
30
WERAM-Xet-0154
atad2
31
WERAM-Xet-0157
brpf1
32
WERAM-Xet-0158
brwd1
33
WERAM-Xet-0182
TRIM66
34
WERAM-Xet-0183
ZMYND8
35
WERAM-Xet-0184
brpf3