Tuber melanosporum      Ac_Reader      Bromodomain

※ Bromodomain family introduction

    Bromodomain: Bromodomains (BRDs) are protein interaction modules that exclusively recognize acetylation motifs. BRDs are evolutionarily conserved and present in diverse nuclear proteins comprising HATs (GCN5, PCAF), ATP-dependent chromatin-remodeling complexes (BAZ1B), helicases (SMARCA), methyltransferases (MLL, ASH1L), transcriptional coactivators (TRIM/TIF1, TAFs) transcriptional mediators (TAF1), nuclear-scaffolding proteins(PB1), and the BET family. Despite large sequence variations, all BRD modules share a conserved fold that comprises a left-handed bundle of four a helices, linked by loop regions of variablelength, which line the Kac binding site and determine binding specificity. (1)

Reference
1. P. Filippakopoulos, S. Picaud, M. Mangos, T. Keates, J.P. Lambert, D. Barsyte-Lovejoy, I. Felletar, R. Volkmer, S. Müller, T. Pawson,et al.Histone recognition and large-scale structural analysis of the human bromodomain family. Cell.2012;149(1):214-231. PMID: 22464331.



There are 7 genes.  Reviewed (0 or Unreviewed (7

No.StatusWERAM IDGene/Alias Name
1
WERAM-Tum-0003
GSTUM_00000163001
2
WERAM-Tum-0005
GSTUM_00001663001
3
WERAM-Tum-0012
GSTUM_00005194001
4
WERAM-Tum-0020
GSTUM_00007482001
5
WERAM-Tum-0021
GSTUM_00007503001
6
WERAM-Tum-0024
GSTUM_00008428001
7
WERAM-Tum-0025
GSTUM_00008645001