Tarsius syrichta      Ac_Reader      Bromodomain

※ Bromodomain family introduction

    Bromodomain: Bromodomains (BRDs) are protein interaction modules that exclusively recognize acetylation motifs. BRDs are evolutionarily conserved and present in diverse nuclear proteins comprising HATs (GCN5, PCAF), ATP-dependent chromatin-remodeling complexes (BAZ1B), helicases (SMARCA), methyltransferases (MLL, ASH1L), transcriptional coactivators (TRIM/TIF1, TAFs) transcriptional mediators (TAF1), nuclear-scaffolding proteins(PB1), and the BET family. Despite large sequence variations, all BRD modules share a conserved fold that comprises a left-handed bundle of four a helices, linked by loop regions of variablelength, which line the Kac binding site and determine binding specificity. (1)

Reference
1. P. Filippakopoulos, S. Picaud, M. Mangos, T. Keates, J.P. Lambert, D. Barsyte-Lovejoy, I. Felletar, R. Volkmer, S. Müller, T. Pawson,et al.Histone recognition and large-scale structural analysis of the human bromodomain family. Cell.2012;149(1):214-231. PMID: 22464331.



There are 30 genes.  Reviewed (0 or Unreviewed (30

No.StatusWERAM IDGene/Alias Name
1
WERAM-Tas-0008
EP300
2
WERAM-Tas-0012
BRD9
3
WERAM-Tas-0013
BAZ2B
4
WERAM-Tas-0018
TRIM24
5
WERAM-Tas-0025
TRIM33
6
WERAM-Tas-0035
BRD7
7
WERAM-Tas-0036
SMARCA2
8
WERAM-Tas-0038
9
WERAM-Tas-0039
BRD2
10
WERAM-Tas-0046
ATAD2
11
WERAM-Tas-0057
BRPF1
12
WERAM-Tas-0058
ATAD2B
13
WERAM-Tas-0062
BAZ1B
14
WERAM-Tas-0063
BPTF
15
WERAM-Tas-0065
KAT2B
16
WERAM-Tas-0068
ZMYND11
17
WERAM-Tas-0069
PBRM1
18
WERAM-Tas-0079
BRWD3
19
WERAM-Tas-0080
BRPF3
20
WERAM-Tas-0081
BAZ2A
21
WERAM-Tas-0083
BRD1
22
WERAM-Tas-0089
SP100
23
WERAM-Tas-0090
BAZ1A
24
WERAM-Tas-0092
BRWD1
25
WERAM-Tas-0100
ZMYND8
26
WERAM-Tas-0103
BRDT
27
WERAM-Tas-0104
CECR2
28
WERAM-Tas-0105
BRD8
29
WERAM-Tas-0111
CREBBP
30
WERAM-Tas-0114
PHIP