Pteropus vampyrus      Ac_Reader      Bromodomain

※ Bromodomain family introduction

    Bromodomain: Bromodomains (BRDs) are protein interaction modules that exclusively recognize acetylation motifs. BRDs are evolutionarily conserved and present in diverse nuclear proteins comprising HATs (GCN5, PCAF), ATP-dependent chromatin-remodeling complexes (BAZ1B), helicases (SMARCA), methyltransferases (MLL, ASH1L), transcriptional coactivators (TRIM/TIF1, TAFs) transcriptional mediators (TAF1), nuclear-scaffolding proteins(PB1), and the BET family. Despite large sequence variations, all BRD modules share a conserved fold that comprises a left-handed bundle of four a helices, linked by loop regions of variablelength, which line the Kac binding site and determine binding specificity. (1)

Reference
1. P. Filippakopoulos, S. Picaud, M. Mangos, T. Keates, J.P. Lambert, D. Barsyte-Lovejoy, I. Felletar, R. Volkmer, S. Müller, T. Pawson,et al.Histone recognition and large-scale structural analysis of the human bromodomain family. Cell.2012;149(1):214-231. PMID: 22464331.



There are 36 genes.  Reviewed (0 or Unreviewed (36

No.StatusWERAM IDGene/Alias Name
1
WERAM-Ptv-0007
SMARCA2
2
WERAM-Ptv-0009
BRD9
3
WERAM-Ptv-0019
TRIM66
4
WERAM-Ptv-0025
SP100
5
WERAM-Ptv-0031
KAT2A
6
WERAM-Ptv-0034
BRD7
7
WERAM-Ptv-0050
8
WERAM-Ptv-0051
BRDT
9
WERAM-Ptv-0059
CREBBP
10
WERAM-Ptv-0062
KAT2B
11
WERAM-Ptv-0063
PHIP
12
WERAM-Ptv-0069
13
WERAM-Ptv-0076
BAZ2A
14
WERAM-Ptv-0079
SMARCA4
15
WERAM-Ptv-0083
TRIM33
16
WERAM-Ptv-0084
BRD3
17
WERAM-Ptv-0100
BPTF
18
WERAM-Ptv-0114
BRD8
19
WERAM-Ptv-0126
TRIM24
20
WERAM-Ptv-0132
BRD2
21
WERAM-Ptv-0133
CECR2
22
WERAM-Ptv-0134
BRD1
23
WERAM-Ptv-0139
PBRM1
24
WERAM-Ptv-0142
EP300
25
WERAM-Ptv-0148
BAZ2B
26
WERAM-Ptv-0149
ATAD2
27
WERAM-Ptv-0151
BAZ1A
28
WERAM-Ptv-0155
BRWD3
29
WERAM-Ptv-0157
ATAD2B
30
WERAM-Ptv-0160
TRIM28
31
WERAM-Ptv-0163
BRPF3
32
WERAM-Ptv-0172
BRWD1
33
WERAM-Ptv-0178
34
WERAM-Ptv-0180
BRD4
35
WERAM-Ptv-0188
ASH1L
36
WERAM-Ptv-0189
ZMYND11