Ornithorhynchus anatinus      Ac_Reader      Bromodomain

※ Bromodomain family introduction

    Bromodomain: Bromodomains (BRDs) are protein interaction modules that exclusively recognize acetylation motifs. BRDs are evolutionarily conserved and present in diverse nuclear proteins comprising HATs (GCN5, PCAF), ATP-dependent chromatin-remodeling complexes (BAZ1B), helicases (SMARCA), methyltransferases (MLL, ASH1L), transcriptional coactivators (TRIM/TIF1, TAFs) transcriptional mediators (TAF1), nuclear-scaffolding proteins(PB1), and the BET family. Despite large sequence variations, all BRD modules share a conserved fold that comprises a left-handed bundle of four a helices, linked by loop regions of variablelength, which line the Kac binding site and determine binding specificity. (1)

Reference
1. P. Filippakopoulos, S. Picaud, M. Mangos, T. Keates, J.P. Lambert, D. Barsyte-Lovejoy, I. Felletar, R. Volkmer, S. Müller, T. Pawson,et al.Histone recognition and large-scale structural analysis of the human bromodomain family. Cell.2012;149(1):214-231. PMID: 22464331.



There are 35 genes.  Reviewed (0 or Unreviewed (35

No.StatusWERAM IDGene/Alias Name
1
WERAM-Ora-0005
BRDT
2
WERAM-Ora-0009
PHIP
3
WERAM-Ora-0015
BRD7
4
WERAM-Ora-0025
BRPF3
5
WERAM-Ora-0029
BRD3
6
WERAM-Ora-0035
KMT2A
7
WERAM-Ora-0037
TRIM24
8
WERAM-Ora-0040
BRD1
9
WERAM-Ora-0045
BAZ2A
10
WERAM-Ora-0046
TRIM33
11
WERAM-Ora-0047
12
WERAM-Ora-0052
KAT2B
13
WERAM-Ora-0056
LOC103165761
14
WERAM-Ora-0059
CREBBP
15
WERAM-Ora-0062
ZMYND11
16
WERAM-Ora-0064
BAZ2B
17
WERAM-Ora-0066
BRD9
18
WERAM-Ora-0067
19
WERAM-Ora-0069
BRWD1
20
WERAM-Ora-0071
TRIM66
21
WERAM-Ora-0076
ATAD2B
22
WERAM-Ora-0077
BPTF
23
WERAM-Ora-0083
BRD4
24
WERAM-Ora-0088
KAT2A
25
WERAM-Ora-0094
SMARCA2
26
WERAM-Ora-0100
27
WERAM-Ora-0101
BRPF1
28
WERAM-Ora-0113
BAZ1A
29
WERAM-Ora-0114
ATAD2
30
WERAM-Ora-0119
EP300
31
WERAM-Ora-0132
LOC103168960
32
WERAM-Ora-0133
LOC100089205
33
WERAM-Ora-0138
LOC103168482
34
WERAM-Ora-0139
35
WERAM-Ora-0142