Ochotona princeps      Ac_Reader      Bromodomain

※ Bromodomain family introduction

    Bromodomain: Bromodomains (BRDs) are protein interaction modules that exclusively recognize acetylation motifs. BRDs are evolutionarily conserved and present in diverse nuclear proteins comprising HATs (GCN5, PCAF), ATP-dependent chromatin-remodeling complexes (BAZ1B), helicases (SMARCA), methyltransferases (MLL, ASH1L), transcriptional coactivators (TRIM/TIF1, TAFs) transcriptional mediators (TAF1), nuclear-scaffolding proteins(PB1), and the BET family. Despite large sequence variations, all BRD modules share a conserved fold that comprises a left-handed bundle of four a helices, linked by loop regions of variablelength, which line the Kac binding site and determine binding specificity. (1)

Reference
1. P. Filippakopoulos, S. Picaud, M. Mangos, T. Keates, J.P. Lambert, D. Barsyte-Lovejoy, I. Felletar, R. Volkmer, S. Müller, T. Pawson,et al.Histone recognition and large-scale structural analysis of the human bromodomain family. Cell.2012;149(1):214-231. PMID: 22464331.



There are 31 genes.  Reviewed (0 or Unreviewed (31

No.StatusWERAM IDGene/Alias Name
1
WERAM-Ocp-0001
PHIP
2
WERAM-Ocp-0004
BPTF
3
WERAM-Ocp-0005
KAT2A
4
WERAM-Ocp-0013
BAZ2A
5
WERAM-Ocp-0023
BRPF1
6
WERAM-Ocp-0025
BAZ1B
7
WERAM-Ocp-0027
BAZ2B
8
WERAM-Ocp-0028
BRD1
9
WERAM-Ocp-0030
BRD8
10
WERAM-Ocp-0032
BRDT
11
WERAM-Ocp-0044
BRD4
12
WERAM-Ocp-0047
CECR2
13
WERAM-Ocp-0053
ASH1L
14
WERAM-Ocp-0054
TRIM24
15
WERAM-Ocp-0060
TRIM33
16
WERAM-Ocp-0065
CREBBP
17
WERAM-Ocp-0071
ATAD2
18
WERAM-Ocp-0076
BRD3
19
WERAM-Ocp-0078
BRD2
20
WERAM-Ocp-0079
BRD9
21
WERAM-Ocp-0089
SP100
22
WERAM-Ocp-0093
PBRM1
23
WERAM-Ocp-0107
KMT2A
24
WERAM-Ocp-0109
BRPF3
25
WERAM-Ocp-0113
EP300
26
WERAM-Ocp-0118
BRWD1
27
WERAM-Ocp-0119
SMARCA2
28
WERAM-Ocp-0131
ZMYND8
29
WERAM-Ocp-0136
BAZ1A
30
WERAM-Ocp-0147
ATAD2B
31
WERAM-Ocp-0151
TRIM28