Loxodonta africana      Ac_Reader      Bromodomain

※ Bromodomain family introduction

    Bromodomain: Bromodomains (BRDs) are protein interaction modules that exclusively recognize acetylation motifs. BRDs are evolutionarily conserved and present in diverse nuclear proteins comprising HATs (GCN5, PCAF), ATP-dependent chromatin-remodeling complexes (BAZ1B), helicases (SMARCA), methyltransferases (MLL, ASH1L), transcriptional coactivators (TRIM/TIF1, TAFs) transcriptional mediators (TAF1), nuclear-scaffolding proteins(PB1), and the BET family. Despite large sequence variations, all BRD modules share a conserved fold that comprises a left-handed bundle of four a helices, linked by loop regions of variablelength, which line the Kac binding site and determine binding specificity. (1)

Reference
1. P. Filippakopoulos, S. Picaud, M. Mangos, T. Keates, J.P. Lambert, D. Barsyte-Lovejoy, I. Felletar, R. Volkmer, S. Müller, T. Pawson,et al.Histone recognition and large-scale structural analysis of the human bromodomain family. Cell.2012;149(1):214-231. PMID: 22464331.



There are 39 genes.  Reviewed (0 or Unreviewed (39

No.StatusWERAM IDGene/Alias Name
1
WERAM-Loa-0004
TRIM66
2
WERAM-Loa-0006
BRD1
3
WERAM-Loa-0012
PHIP
4
WERAM-Loa-0017
TAF1
5
WERAM-Loa-0018
SMARCA4
6
WERAM-Loa-0024
TRIM33
7
WERAM-Loa-0030
SP140
8
WERAM-Loa-0031
ZMYND8
9
WERAM-Loa-0032
BRD9
10
WERAM-Loa-0035
BRWD3
11
WERAM-Loa-0070
KAT2B
12
WERAM-Loa-0079
BRD3
13
WERAM-Loa-0081
BRD8
14
WERAM-Loa-0086
KAT2A
15
WERAM-Loa-0089
BAZ2A
16
WERAM-Loa-0103
TRIM24
17
WERAM-Loa-0105
BAZ1A
18
WERAM-Loa-0114
EP300
19
WERAM-Loa-0127
BRDT
20
WERAM-Loa-0128
SMARCA2
21
WERAM-Loa-0130
BAZ2B
22
WERAM-Loa-0136
KMT2A
23
WERAM-Loa-0138
ZMYND11
24
WERAM-Loa-0140
BRWD1
25
WERAM-Loa-0146
CREBBP
26
WERAM-Loa-0149
PBRM1
27
WERAM-Loa-0152
BRD2
28
WERAM-Loa-0156
BRPF1
29
WERAM-Loa-0159
ATAD2B
30
WERAM-Loa-0163
BPTF
31
WERAM-Loa-0164
BRD7
32
WERAM-Loa-0173
BRPF3
33
WERAM-Loa-0188
TRIM28
34
WERAM-Loa-0195
CECR2
35
WERAM-Loa-0196
36
WERAM-Loa-0199
37
WERAM-Loa-0205
38
WERAM-Loa-0209
39
WERAM-Loa-0211
BRD4