Leersia perrieri      Ac_Reader      Bromodomain

※ Bromodomain family introduction

    Bromodomain: Bromodomains (BRDs) are protein interaction modules that exclusively recognize acetylation motifs. BRDs are evolutionarily conserved and present in diverse nuclear proteins comprising HATs (GCN5, PCAF), ATP-dependent chromatin-remodeling complexes (BAZ1B), helicases (SMARCA), methyltransferases (MLL, ASH1L), transcriptional coactivators (TRIM/TIF1, TAFs) transcriptional mediators (TAF1), nuclear-scaffolding proteins(PB1), and the BET family. Despite large sequence variations, all BRD modules share a conserved fold that comprises a left-handed bundle of four a helices, linked by loop regions of variablelength, which line the Kac binding site and determine binding specificity. (1)

Reference
1. P. Filippakopoulos, S. Picaud, M. Mangos, T. Keates, J.P. Lambert, D. Barsyte-Lovejoy, I. Felletar, R. Volkmer, S. Müller, T. Pawson,et al.Histone recognition and large-scale structural analysis of the human bromodomain family. Cell.2012;149(1):214-231. PMID: 22464331.



There are 19 genes.  Reviewed (0 or Unreviewed (19

No.StatusWERAM IDGene/Alias Name
1
WERAM-Lep-0003
2
WERAM-Lep-0008
3
WERAM-Lep-0009
4
WERAM-Lep-0026
5
WERAM-Lep-0030
6
WERAM-Lep-0034
7
WERAM-Lep-0038
8
WERAM-Lep-0049
9
WERAM-Lep-0061
10
WERAM-Lep-0067
11
WERAM-Lep-0077
12
WERAM-Lep-0086
13
WERAM-Lep-0087
14
WERAM-Lep-0089
15
WERAM-Lep-0092
16
WERAM-Lep-0102
17
WERAM-Lep-0103
18
WERAM-Lep-0105
19
WERAM-Lep-0111