Dasypus novemcinctus      Ac_Reader      Bromodomain

※ Bromodomain family introduction

    Bromodomain: Bromodomains (BRDs) are protein interaction modules that exclusively recognize acetylation motifs. BRDs are evolutionarily conserved and present in diverse nuclear proteins comprising HATs (GCN5, PCAF), ATP-dependent chromatin-remodeling complexes (BAZ1B), helicases (SMARCA), methyltransferases (MLL, ASH1L), transcriptional coactivators (TRIM/TIF1, TAFs) transcriptional mediators (TAF1), nuclear-scaffolding proteins(PB1), and the BET family. Despite large sequence variations, all BRD modules share a conserved fold that comprises a left-handed bundle of four a helices, linked by loop regions of variablelength, which line the Kac binding site and determine binding specificity. (1)

Reference
1. P. Filippakopoulos, S. Picaud, M. Mangos, T. Keates, J.P. Lambert, D. Barsyte-Lovejoy, I. Felletar, R. Volkmer, S. Müller, T. Pawson,et al.Histone recognition and large-scale structural analysis of the human bromodomain family. Cell.2012;149(1):214-231. PMID: 22464331.



There are 39 genes.  Reviewed (0 or Unreviewed (39

No.StatusWERAM IDGene/Alias Name
1
WERAM-Dan-0006
PBRM1
2
WERAM-Dan-0012
3
WERAM-Dan-0021
BRPF1
4
WERAM-Dan-0025
BRD8
5
WERAM-Dan-0028
ZMYND11
6
WERAM-Dan-0036
BRD3
7
WERAM-Dan-0038
TRIM28
8
WERAM-Dan-0044
SP100
9
WERAM-Dan-0047
BAZ2B
10
WERAM-Dan-0048
BRD2
11
WERAM-Dan-0051
SMARCA2
12
WERAM-Dan-0052
13
WERAM-Dan-0054
BAZ1B
14
WERAM-Dan-0058
TRIM33
15
WERAM-Dan-0068
BRWD3
16
WERAM-Dan-0074
BRPF3
17
WERAM-Dan-0077
CECR2
18
WERAM-Dan-0078
CREBBP
19
WERAM-Dan-0083
ZMYND8
20
WERAM-Dan-0084
21
WERAM-Dan-0085
BRD7
22
WERAM-Dan-0086
BAZ2A
23
WERAM-Dan-0087
24
WERAM-Dan-0088
KMT2A
25
WERAM-Dan-0098
BRDT
26
WERAM-Dan-0099
ATAD2B
27
WERAM-Dan-0101
BRWD1
28
WERAM-Dan-0103
KAT2B
29
WERAM-Dan-0111
BRD9
30
WERAM-Dan-0114
PHIP
31
WERAM-Dan-0119
BAZ1A
32
WERAM-Dan-0121
TRIM66
33
WERAM-Dan-0136
BRD1
34
WERAM-Dan-0138
ASH1L
35
WERAM-Dan-0151
BRD4
36
WERAM-Dan-0181
ATAD2
37
WERAM-Dan-0185
KAT2A
38
WERAM-Dan-0200
KIAA2026
39
WERAM-Dan-0204
SMARCA4