Canis familiaris      Ac_Reader      Bromodomain

※ Bromodomain family introduction

    Bromodomain: Bromodomains (BRDs) are protein interaction modules that exclusively recognize acetylation motifs. BRDs are evolutionarily conserved and present in diverse nuclear proteins comprising HATs (GCN5, PCAF), ATP-dependent chromatin-remodeling complexes (BAZ1B), helicases (SMARCA), methyltransferases (MLL, ASH1L), transcriptional coactivators (TRIM/TIF1, TAFs) transcriptional mediators (TAF1), nuclear-scaffolding proteins(PB1), and the BET family. Despite large sequence variations, all BRD modules share a conserved fold that comprises a left-handed bundle of four a helices, linked by loop regions of variablelength, which line the Kac binding site and determine binding specificity. (1)

Reference
1. P. Filippakopoulos, S. Picaud, M. Mangos, T. Keates, J.P. Lambert, D. Barsyte-Lovejoy, I. Felletar, R. Volkmer, S. Müller, T. Pawson,et al.Histone recognition and large-scale structural analysis of the human bromodomain family. Cell.2012;149(1):214-231. PMID: 22464331.



There are 49 genes.  Reviewed (0 or Unreviewed (49

No.StatusWERAM IDGene/Alias Name
1
WERAM-Caf-0001
BAZ2A
2
WERAM-Caf-0005
BRD1
3
WERAM-Caf-0006
BRD2
4
WERAM-Caf-0007
ATAD2
5
WERAM-Caf-0013
EP300
6
WERAM-Caf-0014
7
WERAM-Caf-0015
BRD8
8
WERAM-Caf-0020
BRPF3
9
WERAM-Caf-0024
SMARCA2
10
WERAM-Caf-0029
TRIM28
11
WERAM-Caf-0035
PHIP
12
WERAM-Caf-0046
ATAD2B
13
WERAM-Caf-0064
BRPF1
14
WERAM-Caf-0069
ZMYND11
15
WERAM-Caf-0070
KAT2B
16
WERAM-Caf-0081
TRIM66
17
WERAM-Caf-0099
PBRM1
18
WERAM-Caf-0105
BAZ2B
19
WERAM-Caf-0106
TRIM33
20
WERAM-Caf-0111
BRD7
21
WERAM-Caf-0112
BRWD1
22
WERAM-Caf-0117
23
WERAM-Caf-0118
SP140
24
WERAM-Caf-0121
ZMYND8
25
WERAM-Caf-0122
BRD9
26
WERAM-Caf-0128
BPTF
27
WERAM-Caf-0134
KMT2A
28
WERAM-Caf-0140
BAZ1B
29
WERAM-Caf-0142
BAZ1A
30
WERAM-Caf-0162
KAT2A
31
WERAM-Caf-0165
BRD4
32
WERAM-Caf-0168
CECR2
33
WERAM-Caf-0179
ASH1L
34
WERAM-Caf-0181
35
WERAM-Caf-0186
BRWD3
36
WERAM-Caf-0188
SMARCA4
37
WERAM-Caf-0199
CREBBP
38
WERAM-Caf-0204
39
WERAM-Caf-0209
BRDT
40
WERAM-Caf-0215
41
WERAM-Caf-0216
42
WERAM-Caf-0217
43
WERAM-Caf-0218
44
WERAM-Caf-0219
45
WERAM-Caf-0221
46
WERAM-Caf-0222
47
WERAM-Caf-0225
48
WERAM-Caf-0227
49
WERAM-Caf-0228