Candida glabrata      Ac_Reader      Bromodomain

※ Bromodomain family introduction

    Bromodomain: Bromodomains (BRDs) are protein interaction modules that exclusively recognize acetylation motifs. BRDs are evolutionarily conserved and present in diverse nuclear proteins comprising HATs (GCN5, PCAF), ATP-dependent chromatin-remodeling complexes (BAZ1B), helicases (SMARCA), methyltransferases (MLL, ASH1L), transcriptional coactivators (TRIM/TIF1, TAFs) transcriptional mediators (TAF1), nuclear-scaffolding proteins(PB1), and the BET family. Despite large sequence variations, all BRD modules share a conserved fold that comprises a left-handed bundle of four a helices, linked by loop regions of variablelength, which line the Kac binding site and determine binding specificity. (1)

Reference
1. P. Filippakopoulos, S. Picaud, M. Mangos, T. Keates, J.P. Lambert, D. Barsyte-Lovejoy, I. Felletar, R. Volkmer, S. Müller, T. Pawson,et al.Histone recognition and large-scale structural analysis of the human bromodomain family. Cell.2012;149(1):214-231. PMID: 22464331.



There are 9 genes.  Reviewed (0 or Unreviewed (9

No.StatusWERAM IDGene/Alias Name
1
WERAM-Cag-0004
AO440_000286 AO441_000194
2
WERAM-Cag-0007
AO438_000529 AO438_005071 AO439_000513 AO440_000501 AO441_000379
3
WERAM-Cag-0011
AO438_001533 AO439_001526 AO440_001449 AO441_001341
4
WERAM-Cag-0012
AO438_001591 AO439_001585 AO440_001508 AO441_001401 AO442_001536 AO443_001448
5
WERAM-Cag-0014
AO438_001928 AO439_001923 AO440_001845 AO441_001742
6
WERAM-Cag-0022
AO438_003535 AO439_003510 AO440_003441 AO441_003379
7
WERAM-Cag-0024
AO438_003967 AO439_003942 AO440_004483 AO440_004523 AO441_003812 AO442_004192 AO443_003964
8
WERAM-Cag-0031
AO440_003931
9
WERAM-Cag-0033
AO438_004645 AO439_004621 AO440_004063 AO441_004488