Brachypodium distachyon      Ac_Reader      Bromodomain

※ Bromodomain family introduction

    Bromodomain: Bromodomains (BRDs) are protein interaction modules that exclusively recognize acetylation motifs. BRDs are evolutionarily conserved and present in diverse nuclear proteins comprising HATs (GCN5, PCAF), ATP-dependent chromatin-remodeling complexes (BAZ1B), helicases (SMARCA), methyltransferases (MLL, ASH1L), transcriptional coactivators (TRIM/TIF1, TAFs) transcriptional mediators (TAF1), nuclear-scaffolding proteins(PB1), and the BET family. Despite large sequence variations, all BRD modules share a conserved fold that comprises a left-handed bundle of four a helices, linked by loop regions of variablelength, which line the Kac binding site and determine binding specificity. (1)

Reference
1. P. Filippakopoulos, S. Picaud, M. Mangos, T. Keates, J.P. Lambert, D. Barsyte-Lovejoy, I. Felletar, R. Volkmer, S. Müller, T. Pawson,et al.Histone recognition and large-scale structural analysis of the human bromodomain family. Cell.2012;149(1):214-231. PMID: 22464331.



There are 21 genes.  Reviewed (0 or Unreviewed (21

No.StatusWERAM IDGene/Alias Name
1
WERAM-Brd-0012
BRADI1G24580.1
2
WERAM-Brd-0013
BRADI1G26420.1
3
WERAM-Brd-0018
BRADI1G30648.1
4
WERAM-Brd-0026
BRADI1G51430.1
5
WERAM-Brd-0032
BRADI1G63420.1
6
WERAM-Brd-0038
BRADI1G76370.1
7
WERAM-Brd-0040
BRADI2G06910.1
8
WERAM-Brd-0049
BRADI2G34827.1
9
WERAM-Brd-0052
BRADI2G45190.1
10
WERAM-Brd-0069
BRADI3G09460.1
11
WERAM-Brd-0072
BRADI3G13380.1
12
WERAM-Brd-0075
BRADI3G14940.1
13
WERAM-Brd-0078
BRADI3G26800.1
14
WERAM-Brd-0083
BRADI3G40060.1
15
WERAM-Brd-0087
BRADI3G47960.1
16
WERAM-Brd-0090
BRADI3G51150.1
17
WERAM-Brd-0099
BRADI4G25210.1
18
WERAM-Brd-0111
BRADI4G33820.1
19
WERAM-Brd-0112
BRADI4G35150.1
20
WERAM-Brd-0113
BRADI4G37197.1
21
WERAM-Brd-0129
BRADI5G22200.1