Amborella trichopoda      Ac_Reader      Bromodomain

※ Bromodomain family introduction

    Bromodomain: Bromodomains (BRDs) are protein interaction modules that exclusively recognize acetylation motifs. BRDs are evolutionarily conserved and present in diverse nuclear proteins comprising HATs (GCN5, PCAF), ATP-dependent chromatin-remodeling complexes (BAZ1B), helicases (SMARCA), methyltransferases (MLL, ASH1L), transcriptional coactivators (TRIM/TIF1, TAFs) transcriptional mediators (TAF1), nuclear-scaffolding proteins(PB1), and the BET family. Despite large sequence variations, all BRD modules share a conserved fold that comprises a left-handed bundle of four a helices, linked by loop regions of variablelength, which line the Kac binding site and determine binding specificity. (1)

Reference
1. P. Filippakopoulos, S. Picaud, M. Mangos, T. Keates, J.P. Lambert, D. Barsyte-Lovejoy, I. Felletar, R. Volkmer, S. Müller, T. Pawson,et al.Histone recognition and large-scale structural analysis of the human bromodomain family. Cell.2012;149(1):214-231. PMID: 22464331.



There are 18 genes.  Reviewed (0 or Unreviewed (18

No.StatusWERAM IDGene/Alias Name
1
WERAM-Amt-0002
2
WERAM-Amt-0004
3
WERAM-Amt-0007
4
WERAM-Amt-0015
5
WERAM-Amt-0020
6
WERAM-Amt-0025
7
WERAM-Amt-0030
8
WERAM-Amt-0037
9
WERAM-Amt-0042
10
WERAM-Amt-0054
11
WERAM-Amt-0058
12
WERAM-Amt-0066
13
WERAM-Amt-0071
14
WERAM-Amt-0076
15
WERAM-Amt-0078
16
WERAM-Amt-0079
17
WERAM-Amt-0084
18
WERAM-Amt-0096