WERAM Information

Tag Content
WERAM ID WERAM-Drm-0085
Ensembl Protein ID FBpp0291264
Uniprot Accession Q9V6L0; KDM4B_DROME
Genbank Protein ID NP_001163137.1; NP_001163138.1; NP_001163139.1; NP_788344.2
Protein Name Probable lysine-specific demethylase 4B
Genbank Nucleotide ID NM_001169666.2; NM_001169667.2; NM_001169668.2; NM_176164.4
Gene Name KDM4B;dKDM4B;dJMJD2(2);CG33182
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
FBgn0053182 FBtr0302054 FBpp0291264
FBgn0053182 FBtr0087770 FBpp0086883
FBgn0053182 FBtr0302052 FBpp0291262
FBgn0053182 FBtr0302053 FBpp0291263
FBgn0053182 FBtr0310498 FBpp0302636
Details
Type Family Domain Substrates AA References (PMIDs)
HDM JHDM3_JMJD2 Jmjc H3K9me2/3; H3K36me3 K 26207949
Status Reviewed
Classification
Type Family E-value Score Start End
HDM JHDM3_JMJD2 4.70e-88 294 140 306
Organism Drosophila melanogaster
NCBI Taxa ID 7227
Functional Description
(View)		 Probable histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate (By similarity).
Domain Profile
  HDM JHDM3_JMJD2
    JHDM3.txt   1 dedveeWnlnklktildsvekelkieieGvntpylyvgmlkttfaWhvedmdlysinylhfGapktWyavpseaakrlekllrkefsesakeceaflr 98 
                  d+d+++Wn+n+l+tild v+k+++i+i+Gvnt+yly+gm+kttfaWh+edmdlysinylhfGapktWy+vp+e++++lek++++ f+ s+k+c+a+lr
  FBpp0291264 140 DTDQDSWNINRLGTILDYVNKDYNIQIDGVNTAYLYFGMWKTTFAWHTEDMDLYSINYLHFGAPKTWYVVPPECGRKLEKVANQYFPASYKNCNAYLR 237
                  57899********************************************************************************************* PP
    JHDM3.txt  99 hkttlisPellkkagipfnrivqeagefvitfPygyhaGfnhGfnlaestnfaterwievgkeaakcsc 167
                  hk+tlisP++lk++++p+++i+qeage++itfP+gyhaGfnhGfn+aestnfa+erwie+gk+a++c+c
  FBpp0291264 238 HKMTLISPQILKQHDVPVSKITQEAGEIMITFPFGYHAGFNHGFNCAESTNFAMERWIEYGKRAVQCTC 306
                  ********************************************************************9 PP
Protein Sequence
(Fasta)		MKMSEVPRIK VFRPTWEEFK DFPKYVAYME SQGAHKAGLA KVVPPPEWVP RRSGYADLDA 60
LNVTIPAPIC QVVTGKQGYY QQINIQKKPL TVKQFSELAS TERYATPKHF DFEDLERKYW 120
KNITYVAPIY GADVSGSITD TDQDSWNINR LGTILDYVNK DYNIQIDGVN TAYLYFGMWK 180
TTFAWHTEDM DLYSINYLHF GAPKTWYVVP PECGRKLEKV ANQYFPASYK NCNAYLRHKM 240
TLISPQILKQ HDVPVSKITQ EAGEIMITFP FGYHAGFNHG FNCAESTNFA MERWIEYGKR 300
AVQCTCSNDM VKISMDTFVK RFQSDRYDLW MEGRDVGRHP EDPPNAVLSA APLPPHLDVL 360
LCDKKMKKQC NPTKAKSFKE RNPDLDLDEI QQNPNVPDDV KAMLKESVLT LDTGDLATDE 420
ADFPNEDAMS LQSPANLKTK QELLEYIDDG TEDDDEEEDF KRRKQKRRYD ADYDDDWLAS 480
KRKTNSRNNR GRSPRTKDDR SISPASSTSS TSRGARRGKA SGTPRKTPAR RKKDSITTSP 540
AVSSAATAVK TPTSAVVAGT TSIATTTTPP ADGGGGESSS LGSHCTTASP
Nucleotide Sequence
(Fasta)		ACACTTACAG TCGTGTTTTT TGGTGTTTTT GTATGGGAAG ATTTTTGCGA AAAATAAATT 60
CAGAAGCTAG TGTATTGTGT GTTGTTCCTT TGTGAAATGT AAAGTGGGAC GAACATCAGA 120
GATCGTGTAA GTGCTCCCAT TCGAGTGTGT GTCCATTGGA CTGCAGAGGA AGCGTCTGAT 180
AAGCAGCCAT CTTCCTATAA GAATGGCAAG GAAATTCCTG CCAAATTTAT ATAAATTCTA 240
AGAACTACTG TCGTGCAGCG ATAGCATGGC CGTTCTAGCC GCTCACGAGA TCGAAAAACA 300
ATAGGTTTAG CAACACAACA ACAACAACAC ACTCGCAGAC ATGTGCAACC GAAAGCTAAT 360
CTATTGTAAA TAAACTGCGT CTGCGTCCAT TGTGAACGAG CACCTTTTCT CGGTCACGTA 420
CGCCGATTGC GATTCCTCGA TTCCCGATTC CCCGATTCCG TTGCAACCAG CAGCGCGCTT 480
TGCAAGGAAT TCGCGAAAAA CCAGGTGTTC CACATCTTCC TGAAAACCAG CCGCCCAGAG 540
CTGCCACACG CAGGAGCTGG AGGAGTGCGC GGGGAGGAGG AGAGCAGCAT CGGCGTCATA 600
TCCATCGGTT CCAGATCGAA GCACCCTAGC TGTGAAAGAA GTGTCCGACA ACAGGTCGGA 660
ATTGAAAAAA AAGAGAAAAA CTGAGACGAG AATGAAAATG TCAGAGGTGC CACGCATCAA 720
GGTCTTCCGA CCCACCTGGG AGGAGTTCAA GGACTTTCCC AAGTACGTGG CCTACATGGA 780
GTCCCAGGGT GCCCACAAAG CCGGTTTGGC CAAGGTGGTG CCTCCGCCGG AATGGGTGCC 840
CCGTCGCAGT GGGTACGCCG ATCTCGATGC TCTAAATGTC ACAATTCCGG CGCCCATTTG 900
CCAGGTGGTA ACCGGCAAAC AGGGATACTA CCAGCAGATT AACATCCAGA AAAAGCCACT 960
CACAGTTAAG CAGTTTAGCG AGTTGGCCAG CACCGAGCGT TACGCCACAC CCAAACACTT 1020
TGACTTTGAG GATCTGGAGC GCAAATACTG GAAGAACATA ACATATGTGG CGCCCATTTA 1080
TGGGGCAGAT GTCAGCGGAA GTATCACAGA CACAGACCAG GATAGCTGGA ACATCAACCG 1140
GCTGGGCACA ATTCTTGACT ATGTCAACAA GGATTATAAC ATCCAGATAG ACGGCGTGAA 1200
CACAGCCTAC TTGTACTTTG GCATGTGGAA GACGACCTTT GCATGGCACA CGGAGGACAT 1260
GGATCTCTAT TCCATCAATT ACTTACACTT TGGGGCGCCA AAGACGTGGT ATGTGGTGCC 1320
GCCGGAGTGT GGTCGCAAAT TGGAGAAGGT GGCCAACCAG TACTTTCCGG CCAGTTACAA 1380
GAATTGCAAC GCATATTTGC GCCACAAGAT GACGTTGATT TCACCACAGA TTCTCAAGCA 1440
ACATGACGTG CCCGTCAGTA AGATCACGCA GGAGGCGGGC GAGATCATGA TCACATTTCC 1500
GTTCGGCTAT CATGCCGGCT TCAATCACGG CTTTAACTGT GCCGAGTCCA CCAACTTTGC 1560
CATGGAGCGC TGGATCGAGT ACGGCAAGCG GGCGGTGCAG TGCACCTGCA GCAACGATAT 1620
GGTCAAGATC TCGATGGACA CATTTGTCAA GCGCTTCCAA AGCGATCGCT ACGATCTGTG 1680
GATGGAGGGG CGTGACGTGG GGCGGCATCC GGAGGATCCG CCAAACGCGG TGCTCAGTGC 1740
AGCACCCCTG CCACCACATC TCGATGTCTT GCTGTGTGAT AAAAAAATGA AAAAGCAATG 1800
CAATCCTACC AAGGCCAAGA GTTTCAAAGA GCGTAATCCC GATCTGGACC TGGATGAAAT 1860
CCAGCAGAAT CCCAACGTCC CCGACGACGT CAAGGCCATG CTGAAGGAGA GCGTGCTGAC 1920
GCTGGACACG GGCGATCTGG CCACGGATGA GGCTGATTTT CCCAACGAGG ATGCCATGAG 1980
TCTACAGAGT CCGGCGAATC TGAAGACCAA GCAGGAGCTG CTTGAGTACA TTGACGACGG 2040
CACAGAAGAT GATGATGAGG AGGAGGACTT CAAGCGGCGC AAGCAGAAGC GGCGCTATGA 2100
TGCCGACTAT GACGACGATT GGCTGGCGTC CAAGCGCAAG ACTAACTCGC GAAACAATCG 2160
CGGCCGTAGT CCGCGCACCA AGGACGACCG TTCCATATCG CCGGCCTCCT CCACCTCCTC 2220
GACGTCGAGG GGTGCAAGGC GTGGCAAGGC CAGTGGCACG CCCCGAAAGA CTCCTGCGCG 2280
GCGGAAAAAG GACTCAATCA CCACGTCTCC GGCGGTTAGT TCTGCAGCAA CTGCCGTAAA 2340
AACACCGACA TCCGCCGTAG TCGCTGGAAC AACATCAATA GCCACAACCA CAACACCACC 2400
AGCAGATGGC GGAGGAGGTG AGAGCAGCAG CTTAGGCAGC CACTGCACCA CTGCATCCCC 2460
ATAATCACAG CTTCACCTAT CCACCTCCAA GCCATCCAAA TTCTCTAACC CAATGCCCCA 2520
ATGTCTCTTT TTTAGCAAAA ATCATTCCAA ATTTCCCAGT AGTTTTTTGT TCTAACCAAA 2580
TTGACAATGT TTCAAGCAGT TTCACATGTA TCGTTCATCG TTTTTGTTTT GCGATTAATG 2640
TACAAATAAA TCGTTCTATC TAATTGT 2668
Sequence Source Ensembl
Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0223--Dioxygenase
KW-0408--Iron
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0560--Oxidoreductase
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
--
Interpro

IPR003347--JmjC_dom
IPR003349--JmjN
PROSITE

PS51184--JMJC
PS51183--JMJN
Pfam

PF02373--JmjC
PF02375--JmjN
Gene Ontology

GO:0005634--C:nucleus
GO:0051864--F:histone demethylase activity (H3-K36 specific)
GO:0032454--F:histone demethylase activity (H3-K9 specific)
GO:0046872--F:metal ion binding
GO:0016577--P:histone demethylation
GO:0070544--P:histone H3-K36 demethylation
GO:0033169--P:histone H3-K9 demethylation
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Meg-0063 ENSMGAP00000006048.2 Meleagris gallopavo 65 1e-141 500
WERAM-Gaga-0045 ENSGALP00000006501.4 Gallus gallus 64 3e-141 499
WERAM-Sah-0042 ENSSHAP00000004870.1 Sarcophilus harrisii 60 5e-141 498
WERAM-Pes-0166 ENSPSIP00000019770.1 Pelodiscus sinensis 64 2e-140 496
WERAM-Mod-0013 ENSMODP00000032606.2 Monodelphis domestica 65 3e-140 496
WERAM-Fia-0015 ENSFALP00000001261.1 Ficedula albicollis 64 3e-140 496
WERAM-Tag-0013 ENSTGUP00000000796.1 Taeniopygia guttata 64 4e-140 495
WERAM-Lac-0142 ENSLACP00000016270.1 Latimeria chalumnae 64 1e-139 494
WERAM-Mum-0090 ENSMUSP00000030102.5 Mus musculus 67 2e-139 493
WERAM-Xet-0001 ENSXETP00000001154.3 Xenopus tropicalis 67 2e-139 493
WERAM-Caf-0021 ENSCAFP00000002085.3 Canis familiaris 54 3e-139 492
WERAM-Leo-0132 ENSLOCP00000016408.1 Lepisosteus oculatus 67 4e-139 492
WERAM-Orn-0103 ENSONIP00000011097.1 Oreochromis niloticus 67 4e-139 492
WERAM-Otg-0094 ENSOGAP00000008322.2 Otolemur garnettii 67 5e-139 492
WERAM-Anc-0041 ENSACAP00000004504.3 Anolis carolinensis 67 6e-139 491
WERAM-Mup-0012 ENSMPUP00000001247.1 Mustela putorius furo 54 7e-139 491
WERAM-Aim-0007 ENSAMEP00000000397.1 Ailuropoda melanoleuca 54 7e-139 491
WERAM-Pof-0183 ENSPFOP00000015665.2 Poecilia formosa 66 7e-139 491
WERAM-Poa-0180 ENSPPYP00000021530.1 Pongo abelii 66 8e-139 491
WERAM-Nol-0191 ENSNLEP00000021460.1 Nomascus leucogenys 66 9e-139 491
WERAM-Chs-0109 ENSCSAP00000005249.1 Chlorocebus sabaeus 66 1e-138 491
WERAM-Hos-0265 ENSP00000440656.2 Homo sapiens 66 1e-138 491
WERAM-Gog-0004 ENSGGOP00000000499.2 Gorilla gorilla 66 1e-138 491
WERAM-Cap-0073 ENSCPOP00000005395.2 Cavia porcellus 61 1e-138 490
WERAM-Pat-0088 ENSPTRP00000017561.4 Pan troglodytes 65 1e-138 490
WERAM-Paa-0206 ENSPANP00000019220.1 Papio anubis 66 2e-138 490
WERAM-Vip-0025 ENSVPAP00000002379.1 Vicugna pacos 66 2e-138 490
WERAM-Fec-0092 ENSFCAP00000007646.3 Felis catus 66 2e-138 490
WERAM-Ova-0145 ENSOARP00000014697.1 Ovis aries 66 2e-138 490
WERAM-Mim-0121 ENSMICP00000012586.1 Microcebus murinus 65 2e-138 490
WERAM-Mam-0106 ENSMMUP00000016650.2 Macaca mulatta 65 2e-138 490
WERAM-Eqc-0110 ENSECAP00000012427.1 Equus caballus 67 2e-138 490
WERAM-Caj-0184 ENSCJAP00000031985.2 Callithrix jacchus 65 2e-138 490
WERAM-Xim-0047 ENSXMAP00000004480.1 Xiphophorus maculatus 66 2e-138 489
WERAM-Ocp-0126 ENSOPRP00000013322.1 Ochotona princeps 65 3e-138 489
WERAM-Dar-0141 ENSDARP00000082162.4 Danio rerio 65 3e-138 489
WERAM-Myl-0095 ENSMLUP00000007906.2 Myotis lucifugus 60 4e-138 489
WERAM-Bot-0143 ENSBTAP00000020586.4 Bos taurus 65 4e-138 489
WERAM-Ict-0165 ENSSTOP00000017819.1 Ictidomys tridecemlineatus 67 6e-138 488
WERAM-Gaa-0172 ENSGACP00000021016.1 Gasterosteus aculeatus 61 7e-138 488
WERAM-Loa-0124 ENSLAFP00000011582.3 Loxodonta africana 67 9e-138 488
WERAM-Tut-0165 ENSTTRP00000014088.1 Tursiops truncatus 66 1e-137 487
WERAM-Orc-0061 ENSOCUP00000005900.3 Oryctolagus cuniculus 66 2e-137 486
WERAM-Asm-0230 ENSAMXP00000022237.1 Astyanax mexicanus 65 3e-137 486
WERAM-Ran-0213 ENSRNOP00000066803.1 Rattus norvegicus 66 8e-137 484
WERAM-Ora-0068 ENSOANP00000010212.2 Ornithorhynchus anatinus 65 1e-136 484
WERAM-Dan-0145 ENSDNOP00000027472.1 Dasypus novemcinctus 58 2e-136 483
WERAM-Orla-0066 ENSORLP00000008475.1 Oryzias latipes 65 3e-136 483
WERAM-Gam-0058 ENSGMOP00000005645.1 Gadus morhua 65 6e-136 482
WERAM-Ptv-0162 ENSPVAP00000013602.1 Pteropus vampyrus 65 2e-134 477
WERAM-Tar-0043 ENSTRUP00000010358.1 Takifugu rubripes 65 2e-134 477
WERAM-Ten-0118 ENSTNIP00000012969.1 Tetraodon nigroviridis 64 3e-134 476
WERAM-Tub-0094 ENSTBEP00000011062.1 Tupaia belangeri 65 2e-131 466
WERAM-Sus-0033 ENSSSCP00000005588.2 Sus scrofa 63 6e-128 455
WERAM-Chh-0006 ENSCHOP00000000484.1 Choloepus hoffmanni 65 1e-123 441
WERAM-Ect-0041 ENSETEP00000004107.1 Echinops telfairi 64 3e-118 422
WERAM-Soa-0057 ENSSARP00000005556.1 Sorex araneus 66 5e-115 412
WERAM-Mae-0017 ENSMEUP00000001333.1 Macropus eugenii 58 2e-113 407
WERAM-Anp-0103 ENSAPLP00000012119.1 Anas platyrhynchos 66 5e-112 402
WERAM-Ere-0016 ENSEEUP00000000943.1 Erinaceus europaeus 69 2e-104 377
WERAM-Dio-0105 ENSDORP00000010572.1 Dipodomys ordii 69 4e-102 369
WERAM-Cii-0012 ENSCINP00000004028.3 Ciona intestinalis 63 2e-96 350
WERAM-Cae-0046 Y48B6A.11 Caenorhabditis elegans 46 1e-83 308
WERAM-Cis-0058 ENSCSAVP00000013108.1 Ciona savignyi 67 1e-81 301
WERAM-Cag-0029 CAG62258 Candida glabrata 38 2e-73 274
WERAM-Yal-0032 CAG78224 Yarrowia lipolytica 41 7e-72 269
WERAM-Asg-0030 AAS54607 Ashbya gossypii 35 2e-69 260
WERAM-Tum-0008 CAZ80461 Tuber melanosporum 36 4e-69 259
WERAM-Sac-0014 YER169W Saccharomyces cerevisiae 37 3e-68 256
WERAM-Asni-0024 CADANGAP00006693 Aspergillus niger 37 3e-66 250
WERAM-Kll-0015 CAH01842 Kluyveromyces lactis 36 9e-66 248
WERAM-Caa-0021 KGT68489 Candida albicans 38 4e-65 246
WERAM-Asfu-0032 CADAFUAP00007532 Aspergillus fumigatus 49 3e-63 240
WERAM-Asc-0010 CADACLAP00002196 Aspergillus clavatus 45 4e-63 239
WERAM-Scs-0007 EDN97054 Sclerotinia sclerotiorum 50 2e-62 237
WERAM-Zyt-0023 Mycgr3P48794 Zymoseptoria tritici 49 7e-62 235
WERAM-Trv-0008 EHK16031 Trichoderma virens 51 9e-62 235
WERAM-Ast-0031 CADATEAP00008693 Aspergillus terreus 35 1e-61 235
WERAM-Asn-0010 CADANIAP00001580 Aspergillus nidulans 44 2e-61 234
WERAM-Asf-0016 CADAFLAP00008126 Aspergillus flavus 48 2e-61 234
WERAM-Aso-0001 CADAORAP00000267 Aspergillus oryzae 48 3e-61 233
WERAM-Trr-0030 EGR47972 Trichoderma reesei 49 8e-61 232
WERAM-Ved-0030 EGY16315 Verticillium dahliae 48 8e-61 232
WERAM-Fuo-0032 FOXG_11150P0 Fusarium oxysporum 48 1e-60 231
WERAM-Phn-0009 SNOT_01206 Phaeosphaeria nodorum 47 4e-60 230
WERAM-Nec-0015 EFNCRP00000002609 Neurospora crassa 47 6e-60 229
WERAM-Pytr-0014 EDU46512 Pyrenophora triticirepentis 47 1e-59 228
WERAM-Pyt-0032 EFQ88003 Pyrenophora teres 47 1e-59 228
WERAM-Mao-0026 MGG_09186T0 Magnaporthe oryzae 47 1e-59 228
WERAM-Miv-0023 MVLG_03426T0 Microbotryum violaceum 43 2e-59 228
WERAM-Coi-0033 EAS31415 Coccidioides immitis 47 2e-59 228
Created Date 25-Jun-2016