WERAM Information

Tag Content
WERAM ID WERAM-Drm-0050
Ensembl Protein ID FBpp0087961
Uniprot Accession Q9V333; KDM4A_DROME
Genbank Protein ID NP_610331.1
Protein Name Probable lysine-specific demethylase 4A
Genbank Nucleotide ID NM_136487.4
Gene Name KDM4A;dKDM4A;dJMJD2(1);CG15835
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
FBgn0033233 FBtr0088886 FBpp0087961
FBgn0033233 FBtr0309844 FBpp0301578
Details
Type Family Domain Substrates AA References (PMIDs)
HDM JHDM3_JMJD2 Jmjc H3K9me2/3; H3K36me3 K 26207949
Status Reviewed
Classification
Type Family E-value Score Start End
HDM JHDM3_JMJD2 1.40e-86 289.2 149 315
Organism Drosophila melanogaster
NCBI Taxa ID 7227
Functional Description
(View)		 Probable histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate (By similarity).
Domain Profile
  HDM JHDM3_JMJD2
    JHDM3.txt   1 dedveeWnlnklktildsvekelkieieGvntpylyvgmlkttfaWhvedmdlysinylhfGapktWyavpseaakrlekllrkefsesakeceaflr 98 
                  ded++ Wn+++l+til+ v+++++i i+Gvnt+yly+gm+k++faWh+edmdlysinylhfGapktWya+p+++++rlekl++++fse+++ec+a+lr
  FBpp0087961 149 DEDLDVWNIGRLDTILNLVNTDYNIIIDGVNTAYLYFGMWKSSFAWHTEDMDLYSINYLHFGAPKTWYAIPPAYGRRLEKLANETFSENYQECNAYLR 246
                  68999********************************************************************************************* PP
    JHDM3.txt  99 hkttlisPellkkagipfnrivqeagefvitfPygyhaGfnhGfnlaestnfaterwievgkeaakcsc 167
                  hk+t+isP++l++++ip+n+i+qeage++itfP+gyhaGfnhGfn aestnfa++rwie+gk+a++c+c
  FBpp0087961 247 HKMTMISPKVLRQHNIPYNKITQEAGEIMITFPFGYHAGFNHGFNGAESTNFASKRWIEYGKRASICRC 315
                  ********************************************************************9 PP
Protein Sequence
(Fasta)		MSTRSSFADE EQNKVPRIMT FRPSYEEFQN FSAYIEYIES RGAHLAGLAK IQPPAEWVPR 60
KSGYDIDNIN MTIPAPICQV VTGAHGVYQQ INIQQRRQMT LRQFMEKANS ELHQTPRHFD 120
YDDLERKYWK NITYISPLYA ADVKGSLSDE DLDVWNIGRL DTILNLVNTD YNIIIDGVNT 180
AYLYFGMWKS SFAWHTEDMD LYSINYLHFG APKTWYAIPP AYGRRLEKLA NETFSENYQE 240
CNAYLRHKMT MISPKVLRQH NIPYNKITQE AGEIMITFPF GYHAGFNHGF NGAESTNFAS 300
KRWIEYGKRA SICRCRSDMV KISMETFVRR FQPERYDNWL KGQDMGCHPE EPGKICAAAP 360
PTLNEYEKQE NLRAAKSEEE SPQKRGCSLA GNGCERNAES AEDVDDKASV SSYSSCRQLQ 420
PVVKLRKLPT IASVPEPSSA PKRYDFNTEA VVRVKRLWNE LPCPDRGANL LTNGVVKNTK 480
RMRFQTKVLT LDDED 495
Nucleotide Sequence
(Fasta)		TTCTTGTTAT CTGGTCACAC TAGGCAAAGG AGATTCGTTT CGCTTGCTTA ATTTTTTTGC 60
TGCTCCTTCA ATATGTCCAC GAGATCTTCA TTCGCCGATG AAGAGCAGAA CAAAGTGCCC 120
CGTATCATGA CCTTCCGTCC CAGCTACGAG GAGTTTCAAA ATTTTTCCGC CTACATTGAG 180
TACATTGAGT CTCGGGGAGC ACACTTAGCC GGCTTGGCCA AAATCCAACC ACCTGCGGAA 240
TGGGTGCCCC GAAAGTCGGG CTACGACATA GACAACATCA ACATGACCAT TCCAGCGCCG 300
ATTTGCCAAG TAGTCACTGG GGCGCACGGG GTGTACCAGC AAATCAACAT CCAGCAGCGC 360
CGGCAGATGA CCTTGCGCCA ATTCATGGAG AAGGCCAACT CGGAGCTGCA CCAGACACCG 420
AGGCACTTCG ACTACGACGA TCTGGAGCGC AAGTACTGGA AGAACATCAC CTACATATCG 480
CCACTGTATG CAGCCGATGT CAAGGGATCG CTGAGTGATG AAGACCTTGA CGTTTGGAAC 540
ATTGGACGCT TGGACACCAT ATTAAACTTG GTCAACACTG ACTACAACAT AATCATCGAT 600
GGGGTAAACA CGGCTTACCT CTACTTTGGC ATGTGGAAGA GCTCTTTTGC CTGGCATACC 660
GAGGACATGG ATCTGTATTC TATTAACTAT CTGCATTTTG GAGCACCCAA AACCTGGTAC 720
GCCATTCCGC CGGCGTATGG CAGACGTCTG GAGAAGCTGG CGAACGAAAC CTTCTCTGAG 780
AACTACCAGG AATGCAATGC CTATCTTCGC CATAAGATGA CCATGATCAG TCCGAAGGTG 840
CTGCGCCAGC ACAACATACC TTACAACAAG ATCACGCAGG AAGCGGGCGA AATCATGATT 900
ACATTTCCCT TCGGCTACCA TGCCGGGTTC AATCATGGCT TCAACGGCGC CGAGTCGACC 960
AACTTTGCGT CGAAGCGTTG GATCGAGTAC GGCAAGCGGG CTAGTATTTG CCGATGCCGC 1020
AGCGACATGG TTAAGATCTC GATGGAGACC TTCGTACGCC GTTTCCAGCC AGAGCGATAC 1080
GATAATTGGC TGAAAGGTCA GGACATGGGC TGTCATCCCG AGGAGCCGGG TAAAATATGC 1140
GCTGCAGCAC CACCCACTTT GAATGAGTAC GAGAAACAGG AAAACTTACG TGCAGCCAAA 1200
TCCGAAGAAG AATCTCCGCA GAAGCGAGGC TGCTCGCTGG CCGGCAATGG ATGTGAACGA 1260
AACGCGGAGT CCGCCGAGGA TGTCGACGAT AAGGCCAGTG TGAGCAGCTA TAGCAGCTGC 1320
CGCCAGCTGC AGCCAGTTGT CAAACTACGC AAACTCCCAA CCATTGCGTC TGTACCTGAA 1380
CCATCTTCCG CCCCCAAGAG ATACGACTTC AATACTGAGG CTGTGGTGCG CGTAAAGCGC 1440
CTATGGAATG AACTGCCCTG TCCGGATCGA GGGGCCAACC TGCTCACCAA CGGTGTAGTA 1500
AAGAATACCA AACGAATGCG CTTCCAGACA AAAGTACTCA CACTTGACGA CGAGGATTGA 1560
GGATTCCAGA TGTGGCACTG CTTGCTGGCA GTTTTTGATC TCCTTGTTAG ATTTTCGCGC 1620
CGCAGCAATC AAAGATCTAG TAGTGATATT CTTTGGTAAA TTTTTATACA TTTTAAGAGG 1680
ACATGACGAC ATAACTAAGA AGATATGTGT GTATAATTTA GAAGACAAGC AAATTCGTGC 1740
AAACAAATAT GTAAATCTTT AAGCTGTAGC TGTAGGGCAG ACTGAATTTG TCCGTTCACA 1800
TTTTAATTTA ACAAGTGTCT GTTCCCACCG AAAGAAGTAT TGCAACACAA TTTAAATCTG 1860
AAAATGCCAA AATCATTTTT TAAAGAACAC CCTAAAGGCC AATGTCTATA ATCACACAGA 1920
TATATCGTTT AATAATTTGA TATGTTATGA CATGTGTAAA ATTCTTTGCA ACCAAAAGAG 1980
AAACGCCCAC TAAATTGGCA ACCATTTTTA AGGAACTATC AG 2023
Sequence Source Ensembl
Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0223--Dioxygenase
KW-0408--Iron
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0560--Oxidoreductase
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
--
Interpro

IPR003347--JmjC_dom
IPR003349--JmjN
PROSITE

PS51184--JMJC
PS51183--JMJN
Pfam

PF02373--JmjC
PF02375--JmjN
Gene Ontology

GO:0005634--C:nucleus
GO:0051864--F:histone demethylase activity (H3-K36 specific)
GO:0032454--F:histone demethylase activity (H3-K9 specific)
GO:0046872--F:metal ion binding
GO:0016577--P:histone demethylation
GO:0070544--P:histone H3-K36 demethylation
GO:0033169--P:histone H3-K9 demethylation
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0010628--P:positive regulation of gene expression
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Sah-0042 ENSSHAP00000004870.1 Sarcophilus harrisii 64 5e-134 475
WERAM-Mod-0013 ENSMODP00000032606.2 Monodelphis domestica 64 1e-133 473
WERAM-Meg-0063 ENSMGAP00000006048.2 Meleagris gallopavo 64 2e-133 473
WERAM-Gaga-0045 ENSGALP00000006501.4 Gallus gallus 64 2e-133 473
WERAM-Anc-0086 ENSACAP00000008291.3 Anolis carolinensis 59 4e-133 472
WERAM-Cap-0049 ENSCPOP00000004232.2 Cavia porcellus 62 4e-133 472
WERAM-Pes-0166 ENSPSIP00000019770.1 Pelodiscus sinensis 64 4e-133 472
WERAM-Lac-0142 ENSLACP00000016270.1 Latimeria chalumnae 63 5e-133 471
WERAM-Otg-0094 ENSOGAP00000008322.2 Otolemur garnettii 64 6e-133 471
WERAM-Ocp-0126 ENSOPRP00000013322.1 Ochotona princeps 64 9e-133 471
WERAM-Ora-0068 ENSOANP00000010212.2 Ornithorhynchus anatinus 63 1e-132 470
WERAM-Mum-0131 ENSMUSP00000102011.1 Mus musculus 64 1e-132 470
WERAM-Caf-0021 ENSCAFP00000002085.3 Canis familiaris 63 1e-132 470
WERAM-Chs-0109 ENSCSAP00000005249.1 Chlorocebus sabaeus 62 2e-132 470
WERAM-Leo-0002 ENSLOCP00000000123.1 Lepisosteus oculatus 63 2e-132 470
WERAM-Nol-0150 ENSNLEP00000016264.1 Nomascus leucogenys 63 2e-132 470
WERAM-Poa-0180 ENSPPYP00000021530.1 Pongo abelii 63 2e-132 469
WERAM-Mim-0121 ENSMICP00000012586.1 Microcebus murinus 63 2e-132 469
WERAM-Mup-0012 ENSMPUP00000001247.1 Mustela putorius furo 63 2e-132 469
WERAM-Paa-0206 ENSPANP00000019220.1 Papio anubis 62 3e-132 469
WERAM-Tag-0013 ENSTGUP00000000796.1 Taeniopygia guttata 63 3e-132 469
WERAM-Pat-0088 ENSPTRP00000017561.4 Pan troglodytes 63 3e-132 469
WERAM-Gog-0112 ENSGGOP00000009554.2 Gorilla gorilla 63 3e-132 469
WERAM-Hos-0273 ENSP00000442382.1 Homo sapiens 63 3e-132 469
WERAM-Vip-0025 ENSVPAP00000002379.1 Vicugna pacos 63 3e-132 469
WERAM-Caj-0184 ENSCJAP00000031985.2 Callithrix jacchus 63 3e-132 469
WERAM-Aim-0007 ENSAMEP00000000397.1 Ailuropoda melanoleuca 63 3e-132 469
WERAM-Fec-0150 ENSFCAP00000014024.3 Felis catus 59 4e-132 469
WERAM-Mam-0106 ENSMMUP00000016650.2 Macaca mulatta 63 4e-132 469
WERAM-Bot-0143 ENSBTAP00000020586.4 Bos taurus 63 4e-132 468
WERAM-Ict-0165 ENSSTOP00000017819.1 Ictidomys tridecemlineatus 63 5e-132 468
WERAM-Myl-0095 ENSMLUP00000007906.2 Myotis lucifugus 63 5e-132 468
WERAM-Dar-0206 ENSDARP00000133766.1 Danio rerio 63 6e-132 468
WERAM-Eqc-0110 ENSECAP00000012427.1 Equus caballus 63 6e-132 468
WERAM-Loa-0025 ENSLAFP00000001404.3 Loxodonta africana 63 7e-132 468
WERAM-Ova-0145 ENSOARP00000014697.1 Ovis aries 63 7e-132 468
WERAM-Orc-0034 ENSOCUP00000003513.2 Oryctolagus cuniculus 63 8e-132 468
WERAM-Fia-0015 ENSFALP00000001261.1 Ficedula albicollis 63 1e-131 467
WERAM-Ran-0213 ENSRNOP00000066803.1 Rattus norvegicus 63 1e-131 467
WERAM-Ptv-0162 ENSPVAP00000013602.1 Pteropus vampyrus 63 2e-131 466
WERAM-Orn-0150 ENSONIP00000015836.1 Oreochromis niloticus 62 2e-131 466
WERAM-Orla-0066 ENSORLP00000008475.1 Oryzias latipes 61 3e-131 466
WERAM-Tut-0165 ENSTTRP00000014088.1 Tursiops truncatus 63 3e-131 466
WERAM-Xet-0028 ENSXETP00000007538.3 Xenopus tropicalis 63 3e-131 466
WERAM-Asm-0230 ENSAMXP00000022237.1 Astyanax mexicanus 61 2e-130 463
WERAM-Dan-0145 ENSDNOP00000027472.1 Dasypus novemcinctus 62 8e-130 461
WERAM-Pof-0183 ENSPFOP00000015665.2 Poecilia formosa 60 2e-129 459
WERAM-Xim-0047 ENSXMAP00000004480.1 Xiphophorus maculatus 60 2e-129 459
WERAM-Tub-0094 ENSTBEP00000011062.1 Tupaia belangeri 64 7e-129 458
WERAM-Ten-0118 ENSTNIP00000012969.1 Tetraodon nigroviridis 61 1e-128 457
WERAM-Tar-0098 ENSTRUP00000020050.1 Takifugu rubripes 63 2e-128 456
WERAM-Gaa-0088 ENSGACP00000011572.1 Gasterosteus aculeatus 60 2e-128 456
WERAM-Gam-0058 ENSGMOP00000005645.1 Gadus morhua 61 2e-127 453
WERAM-Sus-0033 ENSSSCP00000005588.2 Sus scrofa 60 9e-121 431
WERAM-Chh-0006 ENSCHOP00000000484.1 Choloepus hoffmanni 63 4e-117 419
WERAM-Ect-0041 ENSETEP00000004107.1 Echinops telfairi 62 3e-114 409
WERAM-Mae-0017 ENSMEUP00000001333.1 Macropus eugenii 57 4e-111 399
WERAM-Soa-0057 ENSSARP00000005556.1 Sorex araneus 63 4e-111 399
WERAM-Anp-0103 ENSAPLP00000012119.1 Anas platyrhynchos 61 1e-102 371
WERAM-Ere-0016 ENSEEUP00000000943.1 Erinaceus europaeus 67 4e-101 365
WERAM-Dio-0105 ENSDORP00000010572.1 Dipodomys ordii 58 3e-100 363
WERAM-Cii-0012 ENSCINP00000004028.3 Ciona intestinalis 61 2e-93 340
WERAM-Cae-0046 Y48B6A.11 Caenorhabditis elegans 47 8e-85 311
WERAM-Cis-0058 ENSCSAVP00000013108.1 Ciona savignyi 64 6e-79 292
WERAM-Cag-0029 CAG62258 Candida glabrata 35 8e-71 265
WERAM-Yal-0032 CAG78224 Yarrowia lipolytica 38 4e-69 259
WERAM-Asni-0024 CADANGAP00006693 Aspergillus niger 36 7e-67 252
WERAM-Tum-0008 CAZ80461 Tuber melanosporum 34 7e-67 252
WERAM-Sac-0014 YER169W Saccharomyces cerevisiae 36 5e-66 249
WERAM-Caa-0021 KGT68489 Candida albicans 40 3e-65 246
WERAM-Asg-0030 AAS54607 Ashbya gossypii 36 1e-64 244
WERAM-Kll-0015 CAH01842 Kluyveromyces lactis 34 1e-59 228
WERAM-Asfu-0032 CADAFUAP00007532 Aspergillus fumigatus 44 2e-59 228
WERAM-Asc-0010 CADACLAP00002196 Aspergillus clavatus 45 3e-59 226
WERAM-Zyt-0023 Mycgr3P48794 Zymoseptoria tritici 47 8e-59 225
WERAM-Ved-0030 EGY16315 Verticillium dahliae 42 4e-58 223
WERAM-Asn-0010 CADANIAP00001580 Aspergillus nidulans 39 5e-58 222
WERAM-Scs-0007 EDN97054 Sclerotinia sclerotiorum 49 6e-58 222
WERAM-Trv-0008 EHK16031 Trichoderma virens 50 1e-57 221
WERAM-Pytr-0014 EDU46512 Pyrenophora triticirepentis 47 2e-57 220
WERAM-Pyt-0032 EFQ88003 Pyrenophora teres 47 2e-57 220
WERAM-Ast-0031 CADATEAP00008693 Aspergillus terreus 44 3e-57 220
WERAM-Lem-0022 CBX90465 Leptosphaeria maculans 46 3e-57 220
WERAM-Kop-0009 CAY68663 Komagataella pastoris 34 3e-57 219
WERAM-Phn-0009 SNOT_01206 Phaeosphaeria nodorum 46 3e-57 219
WERAM-Asf-0016 CADAFLAP00008126 Aspergillus flavus 45 8e-57 218
WERAM-Mao-0026 MGG_09186T0 Magnaporthe oryzae 50 9e-57 218
WERAM-Aso-0001 CADAORAP00000267 Aspergillus oryzae 45 1e-56 218
WERAM-Trr-0030 EGR47972 Trichoderma reesei 49 1e-56 218
WERAM-Gag-0034 GGTG_10896T0 Gaeumannomyces graminis 49 1e-56 218
WERAM-Fuo-0032 FOXG_11150P0 Fusarium oxysporum 47 1e-56 218
Created Date 25-Jun-2016