Classification: Me_Reader WD40※ WD40 family introduction
Me_Reader WD40
WD40: The WD40 domain of EED binds trimethylated lysines through an aromatic cage positioned at the top of the channel of a seven-bladed β-propeller. It is fairly promiscuous and interacts with H3K27me3, H3K9me3, H4K20me3 and H1K26me3. The structure of the EED WD40 in complex with H3K27me3 reveals an important role for the residues flanking K27me3. (1)
Reference
1. Musselman CA, Lalonde ME, Cote J, Kutateladze TG.Perceiving the epigenetic landscape through histone readers. Nat Struct Mol Biol.2012;19(12):1218-27. PMID: 23211769.
Me_Reader WD40