Populus trichocarpa      HMT      SET1

※ SET1 family introduction

    SET1: The SET1 gene in the budding yeast Saccharomyces cerevisiae was discovered by several laboratories as encoding the first known H3K4 methyltransferase, a catalytic function performed through its conserved SET domain. Yeast Set1, like its orthologs in higher eukaryotes (SET1A/B in humans), is recruited to chromatin by the serine 5-phosphorylated C-terminal domain of RNA polymerase II (pol II). This interaction with the initiating form of pol II results in the occupancy of Set1 near the 5’-end of active genes, which correlates closely with the peak of H3K4me3. (1)

    In metazoans, SET1A/B proteins seem to function analogously to yeast Set1 in performing the majority of transcription-coupled H3K4 methylation found at active genes, presumably through co-transcriptional recruitment. Unlike their yeast counterpart, human SET1A/B proteins are also recruited to chromatin via an interaction with non-methylated CpG island sequences, mediated by the SET1A/B-associated protein CFP1.

Reference
1. Ernst P, Vakoc CR.WRAD: enabler of the SET1-family of H3K4 methyltransferases. Brief Funct Genomics.2012;11(3):217-226. PMID: 22652693.



There are 26 genes.  Reviewed (0 or Unreviewed (26

No.StatusWERAM IDGene/Alias Name
1
WERAM-Pot-0021
POPTR_0002s00320g
2
WERAM-Pot-0026
POPTR_0002s07930g
3
WERAM-Pot-0030
POPTR_0002s17180g
4
WERAM-Pot-0031
POPTR_0002s19670g
5
WERAM-Pot-0032
POPTR_0002s23380g
6
WERAM-Pot-0059
POPTR_0007s03790g
7
WERAM-Pot-0064
POPTR_0005s13810g
8
WERAM-Pot-0066
POPTR_0005s18340g
9
WERAM-Pot-0069
POPTR_0005s21720g
10
WERAM-Pot-0072
POPTR_0005s28130g
11
WERAM-Pot-0082
POPTR_0007s00210g
12
WERAM-Pot-0084
POPTR_0007s02850g
13
WERAM-Pot-0086
POPTR_0012s02530g
14
WERAM-Pot-0090
POPTR_0007s10830g
15
WERAM-Pot-0091
POPTR_0007s12130g
16
WERAM-Pot-0128
POPTR_0012s02120g
17
WERAM-Pot-0129
POPTR_0015s01190g
18
WERAM-Pot-0142
POPTR_0014s09400g
19
WERAM-Pot-0143
POPTR_0014s11520g
20
WERAM-Pot-0144
POPTR_0014s14340g
21
WERAM-Pot-0146
22
WERAM-Pot-0148
POPTR_0015s01670g
23
WERAM-Pot-0157
POPTR_0017s00510g
24
WERAM-Pot-0161
POPTR_0017s06870g
25
WERAM-Pot-0163
POPTR_0018s02170g
26
WERAM-Pot-0166
POPTR_0018s11100g