Poecilia formosa      HMT      SET1

※ SET1 family introduction

    SET1: The SET1 gene in the budding yeast Saccharomyces cerevisiae was discovered by several laboratories as encoding the first known H3K4 methyltransferase, a catalytic function performed through its conserved SET domain. Yeast Set1, like its orthologs in higher eukaryotes (SET1A/B in humans), is recruited to chromatin by the serine 5-phosphorylated C-terminal domain of RNA polymerase II (pol II). This interaction with the initiating form of pol II results in the occupancy of Set1 near the 5’-end of active genes, which correlates closely with the peak of H3K4me3. (1)

    In metazoans, SET1A/B proteins seem to function analogously to yeast Set1 in performing the majority of transcription-coupled H3K4 methylation found at active genes, presumably through co-transcriptional recruitment. Unlike their yeast counterpart, human SET1A/B proteins are also recruited to chromatin via an interaction with non-methylated CpG island sequences, mediated by the SET1A/B-associated protein CFP1.

Reference
1. Ernst P, Vakoc CR.WRAD: enabler of the SET1-family of H3K4 methyltransferases. Brief Funct Genomics.2012;11(3):217-226. PMID: 22652693.



There are 20 genes.  Reviewed (0 or Unreviewed (20

No.StatusWERAM IDGene/Alias Name
1
WERAM-Pof-0001
nsd1b
2
WERAM-Pof-0017
setd2
3
WERAM-Pof-0024
KMT2C
4
WERAM-Pof-0045
whsc1
5
WERAM-Pof-0054
ezh2
6
WERAM-Pof-0064
kmt2cb
7
WERAM-Pof-0066
setd8a
8
WERAM-Pof-0072
kmt2bb
9
WERAM-Pof-0076
kmt2d
10
WERAM-Pof-0093
kmt2ba
11
WERAM-Pof-0100
ash1l
12
WERAM-Pof-0129
13
WERAM-Pof-0135
setd8b
14
WERAM-Pof-0148
nsd1a
15
WERAM-Pof-0164
setd1a
16
WERAM-Pof-0165
ezh1
17
WERAM-Pof-0188
kmt2a
18
WERAM-Pof-0208
suv39h1b
19
WERAM-Pof-0239
setd1ba
20
WERAM-Pof-0257