Oreochromis niloticus      HMT      SET1

※ SET1 family introduction

    SET1: The SET1 gene in the budding yeast Saccharomyces cerevisiae was discovered by several laboratories as encoding the first known H3K4 methyltransferase, a catalytic function performed through its conserved SET domain. Yeast Set1, like its orthologs in higher eukaryotes (SET1A/B in humans), is recruited to chromatin by the serine 5-phosphorylated C-terminal domain of RNA polymerase II (pol II). This interaction with the initiating form of pol II results in the occupancy of Set1 near the 5’-end of active genes, which correlates closely with the peak of H3K4me3. (1)

    In metazoans, SET1A/B proteins seem to function analogously to yeast Set1 in performing the majority of transcription-coupled H3K4 methylation found at active genes, presumably through co-transcriptional recruitment. Unlike their yeast counterpart, human SET1A/B proteins are also recruited to chromatin via an interaction with non-methylated CpG island sequences, mediated by the SET1A/B-associated protein CFP1.

Reference
1. Ernst P, Vakoc CR.WRAD: enabler of the SET1-family of H3K4 methyltransferases. Brief Funct Genomics.2012;11(3):217-226. PMID: 22652693.



There are 16 genes.  Reviewed (0 or Unreviewed (16

No.StatusWERAM IDGene/Alias Name
1
WERAM-Orn-0017
ezh1
2
WERAM-Orn-0025
kmt2bb
3
WERAM-Orn-0031
setd2
4
WERAM-Orn-0070
kmt2a
5
WERAM-Orn-0120
kmt2cb
6
WERAM-Orn-0122
setd1a
7
WERAM-Orn-0133
setd1bb
8
WERAM-Orn-0140
suv39h1b
9
WERAM-Orn-0146
kmt2d
10
WERAM-Orn-0148
whsc1
11
WERAM-Orn-0170
setd1ba
12
WERAM-Orn-0179
whsc1l1
13
WERAM-Orn-0186
setd8a
14
WERAM-Orn-0214
ezh2
15
WERAM-Orn-0231
ash1l
16
WERAM-Orn-0232
kmt2ba