Mus musculus      HMT      SET1

※ SET1 family introduction

    SET1: The SET1 gene in the budding yeast Saccharomyces cerevisiae was discovered by several laboratories as encoding the first known H3K4 methyltransferase, a catalytic function performed through its conserved SET domain. Yeast Set1, like its orthologs in higher eukaryotes (SET1A/B in humans), is recruited to chromatin by the serine 5-phosphorylated C-terminal domain of RNA polymerase II (pol II). This interaction with the initiating form of pol II results in the occupancy of Set1 near the 5’-end of active genes, which correlates closely with the peak of H3K4me3. (1)

    In metazoans, SET1A/B proteins seem to function analogously to yeast Set1 in performing the majority of transcription-coupled H3K4 methylation found at active genes, presumably through co-transcriptional recruitment. Unlike their yeast counterpart, human SET1A/B proteins are also recruited to chromatin via an interaction with non-methylated CpG island sequences, mediated by the SET1A/B-associated protein CFP1.

Reference
1. Ernst P, Vakoc CR.WRAD: enabler of the SET1-family of H3K4 methyltransferases. Brief Funct Genomics.2012;11(3):217-226. PMID: 22652693.



There are 14 genes.  Reviewed (4 or Unreviewed (10

No.StatusWERAM IDGene/Alias Name
1
WERAM-Mum-0008
KMT2A
2
WERAM-Mum-0101
EZH2
3
WERAM-Mum-0152
KMT2C; MLL3
4
WERAM-Mum-0185
KMT2D
5
WERAM-Mum-0016
Kmt2b
6
WERAM-Mum-0018
Ezh1
7
WERAM-Mum-0037
Nsd1
8
WERAM-Mum-0089
Ash1l
9
WERAM-Mum-0155
Setd1b
10
WERAM-Mum-0173
Setd1a
11
WERAM-Mum-0187
Setd8
12
WERAM-Mum-0196
Whsc1l1
13
WERAM-Mum-0202
Whsc1
14
WERAM-Mum-0295
RP23-325D10.3