Medicago truncatula      HMT      SET1

※ SET1 family introduction

    SET1: The SET1 gene in the budding yeast Saccharomyces cerevisiae was discovered by several laboratories as encoding the first known H3K4 methyltransferase, a catalytic function performed through its conserved SET domain. Yeast Set1, like its orthologs in higher eukaryotes (SET1A/B in humans), is recruited to chromatin by the serine 5-phosphorylated C-terminal domain of RNA polymerase II (pol II). This interaction with the initiating form of pol II results in the occupancy of Set1 near the 5’-end of active genes, which correlates closely with the peak of H3K4me3. (1)

    In metazoans, SET1A/B proteins seem to function analogously to yeast Set1 in performing the majority of transcription-coupled H3K4 methylation found at active genes, presumably through co-transcriptional recruitment. Unlike their yeast counterpart, human SET1A/B proteins are also recruited to chromatin via an interaction with non-methylated CpG island sequences, mediated by the SET1A/B-associated protein CFP1.

Reference
1. Ernst P, Vakoc CR.WRAD: enabler of the SET1-family of H3K4 methyltransferases. Brief Funct Genomics.2012;11(3):217-226. PMID: 22652693.



There are 22 genes.  Reviewed (0 or Unreviewed (22

No.StatusWERAM IDGene/Alias Name
1
WERAM-Met-0003
MTR_0071s0100
2
WERAM-Met-0006
MTR_1g007670
3
WERAM-Met-0007
MTR_1g007700
4
WERAM-Met-0009
MTR_1g008230
5
WERAM-Met-0010
MTR_1g012890
6
WERAM-Met-0011
MTR_1g012910
7
WERAM-Met-0027
MTR_1g086980
8
WERAM-Met-0030
MTR_1g098000
9
WERAM-Met-0031
MTR_1g098370
10
WERAM-Met-0043
MTR_2g036060
11
WERAM-Met-0053
MTR_2g089080
12
WERAM-Met-0069
MTR_3g088625
13
WERAM-Met-0071
MTR_3g091310
14
WERAM-Met-0073
MTR_3g095840
15
WERAM-Met-0095
MTR_4g045743
16
WERAM-Met-0123
MTR_5g016870
17
WERAM-Met-0143
MTR_6g059310
18
WERAM-Met-0147
MTR_7g021365
19
WERAM-Met-0149
MTR_7g055660
20
WERAM-Met-0161
MTR_7g109560
21
WERAM-Met-0164
MTR_7g117355
22
WERAM-Met-0173
MTR_8g027725