Gasterosteus aculeatus      HMT      SET1

※ SET1 family introduction

    SET1: The SET1 gene in the budding yeast Saccharomyces cerevisiae was discovered by several laboratories as encoding the first known H3K4 methyltransferase, a catalytic function performed through its conserved SET domain. Yeast Set1, like its orthologs in higher eukaryotes (SET1A/B in humans), is recruited to chromatin by the serine 5-phosphorylated C-terminal domain of RNA polymerase II (pol II). This interaction with the initiating form of pol II results in the occupancy of Set1 near the 5’-end of active genes, which correlates closely with the peak of H3K4me3. (1)

    In metazoans, SET1A/B proteins seem to function analogously to yeast Set1 in performing the majority of transcription-coupled H3K4 methylation found at active genes, presumably through co-transcriptional recruitment. Unlike their yeast counterpart, human SET1A/B proteins are also recruited to chromatin via an interaction with non-methylated CpG island sequences, mediated by the SET1A/B-associated protein CFP1.

Reference
1. Ernst P, Vakoc CR.WRAD: enabler of the SET1-family of H3K4 methyltransferases. Brief Funct Genomics.2012;11(3):217-226. PMID: 22652693.



There are 20 genes.  Reviewed (0 or Unreviewed (20

No.StatusWERAM IDGene/Alias Name
1
WERAM-Gaa-0026
ash1l
2
WERAM-Gaa-0036
kmt2ba
3
WERAM-Gaa-0041
whsc1
4
WERAM-Gaa-0055
ezh2
5
WERAM-Gaa-0057
6
WERAM-Gaa-0058
whsc1l1
7
WERAM-Gaa-0074
kmt2bb
8
WERAM-Gaa-0080
setd8b
9
WERAM-Gaa-0084
ezh1
10
WERAM-Gaa-0091
kmt2a
11
WERAM-Gaa-0092
kmt2d
12
WERAM-Gaa-0124
setd1bb
13
WERAM-Gaa-0130
ezh2
14
WERAM-Gaa-0131
suv39h1b
15
WERAM-Gaa-0138
kmt2cb
16
WERAM-Gaa-0140
setd1a
17
WERAM-Gaa-0167
setd8a
18
WERAM-Gaa-0181
setd1ba
19
WERAM-Gaa-0191
nsd1a
20
WERAM-Gaa-0222
nsd1b