Danio rerio      HMT      SET1

※ SET1 family introduction

    SET1: The SET1 gene in the budding yeast Saccharomyces cerevisiae was discovered by several laboratories as encoding the first known H3K4 methyltransferase, a catalytic function performed through its conserved SET domain. Yeast Set1, like its orthologs in higher eukaryotes (SET1A/B in humans), is recruited to chromatin by the serine 5-phosphorylated C-terminal domain of RNA polymerase II (pol II). This interaction with the initiating form of pol II results in the occupancy of Set1 near the 5’-end of active genes, which correlates closely with the peak of H3K4me3. (1)

    In metazoans, SET1A/B proteins seem to function analogously to yeast Set1 in performing the majority of transcription-coupled H3K4 methylation found at active genes, presumably through co-transcriptional recruitment. Unlike their yeast counterpart, human SET1A/B proteins are also recruited to chromatin via an interaction with non-methylated CpG island sequences, mediated by the SET1A/B-associated protein CFP1.

Reference
1. Ernst P, Vakoc CR.WRAD: enabler of the SET1-family of H3K4 methyltransferases. Brief Funct Genomics.2012;11(3):217-226. PMID: 22652693.



There are 20 genes.  Reviewed (0 or Unreviewed (20

No.StatusWERAM IDGene/Alias Name
1
WERAM-Dar-0010
kmt2a
2
WERAM-Dar-0027
ezh2
3
WERAM-Dar-0064
whsc1
4
WERAM-Dar-0066
suv39h1a
5
WERAM-Dar-0080
kmt2d
6
WERAM-Dar-0083
ezh1
7
WERAM-Dar-0113
suv39h1b
8
WERAM-Dar-0128
nsd1a
9
WERAM-Dar-0130
setd1a
10
WERAM-Dar-0134
kmt2bb
11
WERAM-Dar-0135
nsd1b
12
WERAM-Dar-0136
setd1ba
13
WERAM-Dar-0144
setd2
14
WERAM-Dar-0147
whsc1l1
15
WERAM-Dar-0149
kmt2ba
16
WERAM-Dar-0162
ash1l
17
WERAM-Dar-0173
kmt2cb
18
WERAM-Dar-0184
kmt2ca
19
WERAM-Dar-0229
setd8b
20
WERAM-Dar-0241
setd8a