Brassica rapa      HMT      SET1

※ SET1 family introduction

    SET1: The SET1 gene in the budding yeast Saccharomyces cerevisiae was discovered by several laboratories as encoding the first known H3K4 methyltransferase, a catalytic function performed through its conserved SET domain. Yeast Set1, like its orthologs in higher eukaryotes (SET1A/B in humans), is recruited to chromatin by the serine 5-phosphorylated C-terminal domain of RNA polymerase II (pol II). This interaction with the initiating form of pol II results in the occupancy of Set1 near the 5’-end of active genes, which correlates closely with the peak of H3K4me3. (1)

    In metazoans, SET1A/B proteins seem to function analogously to yeast Set1 in performing the majority of transcription-coupled H3K4 methylation found at active genes, presumably through co-transcriptional recruitment. Unlike their yeast counterpart, human SET1A/B proteins are also recruited to chromatin via an interaction with non-methylated CpG island sequences, mediated by the SET1A/B-associated protein CFP1.

Reference
1. Ernst P, Vakoc CR.WRAD: enabler of the SET1-family of H3K4 methyltransferases. Brief Funct Genomics.2012;11(3):217-226. PMID: 22652693.



There are 22 genes.  Reviewed (0 or Unreviewed (22

No.StatusWERAM IDGene/Alias Name
1
WERAM-Brr-0001
2
WERAM-Brr-0012
SDG29
3
WERAM-Brr-0013
4
WERAM-Brr-0014
SDG14
5
WERAM-Brr-0019
ASHH3
6
WERAM-Brr-0038
ASHH4
7
WERAM-Brr-0046
ATXR5
8
WERAM-Brr-0051
9
WERAM-Brr-0056
ASHR3
10
WERAM-Brr-0078
EFS
11
WERAM-Brr-0080
SDG26
12
WERAM-Brr-0112
ATX1
13
WERAM-Brr-0140
ATXR7
14
WERAM-Brr-0141
15
WERAM-Brr-0147
16
WERAM-Brr-0159
CLF
17
WERAM-Brr-0162
18
WERAM-Brr-0163
19
WERAM-Brr-0183
EZA1
20
WERAM-Brr-0185
21
WERAM-Brr-0199
22
WERAM-Brr-0206
ATX4